Tissue-mimicking bladder wall phantoms for evaluating acoustic radiation force-optical coherence elastography systems

Abstract

A material that mimics the mechanical, optical, and acoustic properties of healthy bladder wall has been developed. This tissue-mimicking bladder wall phantom was developed as a control tool to investigate the feasibility of using ARF-OCE to detect the mechanical and optical changes that may be indicative of the onset or development of cancer in the urinary bladder. By following the methods used in this article, phantoms matching the optical, acoustic, and mechanical properties of other biological tissues can also be constructed.

Automated, Depth-Resolved Estimation of the Attenuation Coefficient From Optical Coherence Tomography Data

“…3(a) shows the effect of contrast between the layers ranging from 0.5 mm −1 to 3 mm −1 . These values reflect the range of attenuation coefficients that are reasonable to detect using OCT [34] and that can be seen in actual tissue; for example, the three layers of the bladder visible with OCT have attenuation coefficients of approximately 0.49 mm −1 , 2 mm −1 , and 1.38 mm −1 [35]. For all simulations, the attenuation coefficient of the top layer was fixed at 1 mm −1 , the focal plane was located at a depth of 0.5 mm, and the layer thicknesses were all 1 mm.…”

Multilayered tissue mimicking skin and vessel phantoms with tunable mechanical, optical, and acoustic properties

“…The attenuation coefficient α 1 of 1% BSA is ∼0.02 dB cm −1 MHz −1 and increases linearly with concentration. 31,32 Here we added 35% lyophilized BSA (≥95% purity, Roche Diagnostics, USA), which was expected to raise α 1 in the dermis layer from ∼0.5 to ∼1.1 dB cm −1 MHz −1 . Similarly, 15% BSA was added to the hypodermis layer to raise α 1 from ∼0.3 to ∼0.6 dB cm −1 MHz −1 .…”

Measurement of Optical Scattering Coefficient of the Individual Layers of the Human Urinary Bladder Using Optical Coherence Tomography

“…This procedure was implemented using an algorithm implemented in MATLAB (The Mathworks, Natick, MA, USA). The algorithm has already been successfully used to adequately characterize the optical properties of bladder-wall phantoms [9,10].…”