Tissue Optical Properties in Relation to Light Propagation Models and in Vivo Dosimetry

Wilson, Brian C.; Patterson, Michael S.; Flock, Stephen Thomas; Wyman, D. R.

doi:10.1007/978-1-4757-6178-8_3

Cited by 18 publications

(8 citation statements)

References 23 publications

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“…The term "photon migration" refers to photons propagating diffusely throughout the tissue ͑i.e., in a random direction͒. 24 Quantitative DOS is based on time-or frequency-domain photon migration ͑FDPM͒ technology. In FDPM, near-infrared ͑NIR͒ light intensity modulated over a range of frequencies is used to characterize tissue in terms of optical parameters, i.e., the reduced scattering coefficient ͑ s Ј͒ and absorption coefficient ͑ a ͒.…”

Section: Diffuse Optical Spectroscopymentioning

confidence: 99%

In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy

et al. 2006

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Diffuse optical imaging (DOI) may be a beneficial diagnostic method for women with mammographically dense breast tissue. In order to evaluate the utility of DOI, we are developing broadband diffuse optical spectroscopy (DOS) to characterize the functional origins of optical signals in breast cancer patients. Broadband DOS combines multifrequency intensity-modulated and continuous-wave near-infrared light to quantify tissue absorption and scattering spectra from 650 to 1000 nm. Values of intrinsic physiological properties (oxy- and deoxy-hemoglobin, water, lipid, and scatter power) derived from absorption and scattering spectra provide detailed information on breast physiology. We present the results of clinical studies of 58 stage II/III malignant breast tumors using a noninvasive, handheld, broadband DOS probe. On average, eight positions were scanned over tumor and contralateral normal breast for each subject. Intrinsic physiological properties were statistically significantly different for malignant vs. normal tissues for all subjects, without patient age or tumor size/type stratification. Breast tissues containing malignant tumors displayed reduced lipid content ( approximately 20%) and increased water, deoxy-, and oxy-hemoglobin (>50% each) compared to normal breast tissues. Functional perturbations by the tumor were significantly larger than functional variations in normal tissues. A tissue optical index (TOI) derived from intrinsic physiological properties yielded an average two-fold contrast difference between malignant tumors and intrinsic tissue properties. Our results demonstrate that intrinsic optical signals can be influenced by functional perturbations characteristic of malignant transformation; cellular metabolism, extracellular matrix composition, and angiogenesis. Our findings further underscore the importance of broadband measurements and patient age stratification in breast cancer DOI.

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Section: Diffuse Optical Spectroscopymentioning

confidence: 99%

In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy

et al. 2006

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“…9,10 Light transport in tis-sues is dominated by scattering processes within the visible and NIR regions of the spectrum. 11 Multiple scattering leads to a phenomenon called photon migration, in which individual photons can be thought of as undergoing a random walk through the tissue, traveling along a wide variety of complex paths. The general problem of multiple scattering of light inside tissuelike materials has received considerable attention in recent years.…”

Section: B Noninvasive Fluorescence: the Problem Of Multiple Scatteringmentioning

confidence: 99%

Experimental verification of a theory for the time-resolved fluorescence spectroscopy of thick tissues

Cerussi¹,

Maier²,

Fantini³

et al. 1997

Appl. Opt.

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Fluorescence spectroscopy provides potential contrast enhancement for near-infrared tissue imaging and physiologically correlated spectroscopy. We present a fluorescence photon migration model and test its quantitative predictive capabilities with a frequency-domain measurement that involves a homogeneous multiple-scattering tissue phantom ͑with optical properties similar to those of tissue in the near infrared͒ that contains a fluorophore ͑rhodamine B͒. After demonstrating the validity of the model, we explore its ability to recover the fluorophore's spectral properties from within the multiple-scattering medium. The absolute quantum yield and the lifetime of the fluorophore are measured to within a few percent of the values measured independently in the absence of scattering. Both measurements are accomplished without the use of reference fluorophores. In addition, the model accurately predicts the fluorescence emission spectrum in the scattering medium. Implications of these absolute measurements of lifetime, quantum yield, concentration, and emission spectrum from within multiple-scattering media are discussed.

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“…2,3 The wavelength region of interest is approximately 650-1300 nm, where transmission through tissue is highest. 4 The dilemma encountered when breast imaging is performed at these wavelengths is that the dominating attenuation process is scattering. This leads to blurred images and poor resolution.…”

Section: Introductionmentioning

confidence: 99%

Time-gated viewing studies on tissuelike phantoms

et al. 1996

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A time-gated technique to enhance viewing through highly scattering media such as tissue is discussed. Experiments have been performed on tissuelike plastic phantoms to determine the possibilities and limitations of the technique. The effects of the time-gate width and the localization, size, and optical properties of hidden objects have been studied. A computer model to simulate light propagation in tissue is also presented. The predictions of the model are compared with experimental results.

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Tissue Optical Properties in Relation to Light Propagation Models and in Vivo Dosimetry

Cited by 18 publications

References 23 publications

In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy

In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy

Experimental verification of a theory for the time-resolved fluorescence spectroscopy of thick tissues

Time-gated viewing studies on tissuelike phantoms

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