Tissue persistence of fumonisin B1 in ducks and after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds

Tardieu, Didier; Bailly, Jean‐Denis; Benlashehr, Imad; Auby, Aliénor; Jouglar, J.Y.; Guerre, Philippe

doi:10.1016/j.cbi.2009.06.009

Cited by 16 publications

(23 citation statements)

References 14 publications

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“…Vudathula et al [ 29 ] showed an oral bioavailability (F) of 0.71% in laying hens administered 2 mg [14C]FB 1 /kg bodyweight (BW). In turkeys and ducks, a similar F was demonstrated after administering 100 mg FB 1 /kg BW, namely 2.0%–2.3% and 3.2%, respectively [ 27 , 28 ]. Benlashehr et al [ 30 ] demonstrated that the toxicokinetics parameters of FB 2 are not strongly different from these of FB 1 in ducks and turkeys.…”

Section: Introductionmentioning

confidence: 77%

“…No mortality has been recorded in laying hens, turkeys or older broiler chickens fed high doses of FB 1 (≥200 mg/kg feed) for several weeks [ 20 , 21 , 23 , 25 ]. Moreover, it has been shown that FBs can reduce growth performance, and induce alterations in serum constituents and enzyme activities demonstrating hepatic toxicity in broilers, turkeys and ducks [ 20 , 21 , 22 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Exposure to Deoxynivalenol Has No Influence on the Oral Bioavailability of Fumonisin B1 in Broiler Chickens

Antonissen

Devreese

Immerseel

et al. 2015

Toxins

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Both deoxynivalenol (DON) and fumonisin B1 (FB1) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals. Previous studies have demonstrated that chronic exposure to DON impairs the intestinal barrier function and integrity, by affecting the intestinal surface area and function of the tight junctions. This might influence the oral bioavailability of FB1, and possibly lead to altered toxicity of this mycotoxin. A toxicokinetic study was performed with two groups of 6 broiler chickens, which were all administered an oral bolus of 2.5 mg FBs/kg BW after three-week exposure to either uncontaminated feed (group 1) or feed contaminated with 3.12 mg DON/kg feed (group 2). No significant differences in toxicokinetic parameters of FB1 could be demonstrated between the groups. Also, no increased or decreased body exposure to FB1 was observed, since the relative oral bioavailability of FB1 after chronic DON exposure was 92.2%.

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Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Chronic Exposure to Deoxynivalenol Has No Influence on the Oral Bioavailability of Fumonisin B1 in Broiler Chickens

Antonissen

Devreese

Immerseel

et al. 2015

Toxins

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“…When a single dose of 7.5 mg 14 C-FB 1 /kg bw was injected i.p. After administration of a single oral dose of 100 mg FB 1 /kg bw to turkey poults and ducks, plasma levels peaked at 3 h and at 1-2 h, and bioavailability was about 3% and 2% in turkey poults (Tardieu et al, 2008) and in ducks (Tardieu et al, 2009), respectively. This finding again supports the low absorption after oral administration.…”

Section: Fumonisin Bsmentioning

confidence: 99%

Appropriateness to set a group health‐based guidance value for fumonisins and their modified forms

Knutsen¹,

Barregård²,

Bignami³

et al. 2018

EFS2

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The EFSA Panel on Contaminants in the Food Chain (CONTAM) established a tolerable daily intake (TDI) for fumonisin B 1 (FB 1 ) of 1.0 lg/kg body weight (bw) per day based on increased incidence of megalocytic hepatocytes found in a chronic study with mice. The CONTAM Panel considered the limited data available on toxicity and mode of action and structural similarities of FB 2-6 and found it appropriate to include FB 2 , FB 3 and FB 4 in a group TDI with FB 1 . Modified forms of FBs are phase I and phase II metabolites formed in fungi, infested plants or farm animals. Modified forms also arise from food or feed processing, and include covalent adducts with matrix constituents. Non-covalently bound forms are not considered as modified forms. Modified forms of FBs identified are hydrolysed FB 1-4 (HFB 1-4 ), partially hydrolysed FB 1-2 (pHFB 1-2 ), N-(carboxymethyl)-FB 1-3 (NCM-FB 1-3 ), N-(1deoxy-D-fructos-1-yl)-FB 1 (NDF-FB 1 ), O-fatty acyl FB 1 , N-fatty acyl FB 1 and N-palmitoyl-HFB 1 . HFB 1 , pHFB 1 , NCM-FB 1 and NDF-FB 1 show a similar toxicological profile but are less potent than FB 1 . Although in vitro data shows that N-fatty acyl FBs are more toxic in vitro than FB 1 , no in vivo data were available for N-fatty acyl FBs and O-fatty acyl FBs. The CONTAM Panel concluded that it was not appropriate to include modified FBs in the group TDI for FB 1-4 . The uncertainty associated with the present assessment is high, but could be reduced provided more data are made available on occurrence, toxicokinetics and toxicity of FB 2-6 and modified forms of FB 1-4 . and Alexander J, 2018. Scientific opinion on the appropriateness to set a group health-based guidance value for fumonisins and their modified forms. EFSA Journal 2018;16(2):5172, 75 pp. https://doi.This is an open access article under the terms of the Creative Commons Attribution-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.The EFSA Journal is a publication of the European Food Safety Authority, an agency of the European Union. HBGV for fumonisins and their modified forms www.efsa.europa.eu/efsajournal 2 EFSA Journal 2018;16(2):5172 HBGV for fumonisins and their modified forms www.efsa.europa.eu/efsajournal 3 EFSA Journal 2018;16(2):5172Although FBs are poorly absorbed, unchanged FBs excreted into urine have been used as a biomarker of exposure in humans. In animal studies changes in sphinganine (Sa) and sphingosine (So) and the Sa/So ratio can be determined in urine following FB exposure. A dose related increase in the sphinganine 1-phosphate (Sa 1-P)/sphingosine 1-phosphate (So 1-P) ratio in blood spots which correlated with urinary FB 1 levels has been reported in human studies. This result is consistent with fumonisin inhibition of CerS in humans.Toxicity studies deal mainly with effects of FB 1 , but FB 2-4 are considered as having similar toxicological profiles and potencies. FB 1 is considered not to be acutely toxic. In repeated dose st...

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“…Rauber et al (2013) verificaram diminuição significativa sobre o ganho de peso e consumo de ração em frangos de corte alimentados com fumonisina (100 e 200 mg/kg). Tardieu et al (2009), realizaram um estudo em patos machos, com alimentação forçada de diferentes concentrações de fumonisinas (0, 5, 10 e 20 mg/kg de FB1+FB2) durante 12 semanas. Mortalidade e sinais de toxicidade foram observados apenas na dieta contendo 20 mg/kg de fumonisinas, diferentemente do presente trabalho.…”

Section: Dietas Experimentaisunclassified

“…Esse valor encontrado de resíduo de fumonisina (117 µg/kg ou ng/g), para 20 mg/kg de fumonisinas, foi menor que o encontrado no presente trabalho para as dietas contendo FB1 (159,04 ng/g), AFB1+CMT (221,90 ng/g) e AFB1+FB1+CMT (123,56 ng/g). Tardieu et al (2009), realizaram um estudo semelhante em patos machos, alimentados (alimentação forçada) com diferentes concentrações de fumonisinas (0, 5, 10 e 20 mg/kg de FB1+FB2) durante 12 semanas. Apesar da ingestão total de fumonisinas ter sido maior em patos quando comparada com a dos perus, a persistência foi menor.…”

Section: Dietas Experimentaisunclassified

Efeitos da administração da aflatoxina, fumonisina e curcumina, isoladas ou associadas, sobre a resposta imunológica humoral e determinação de produtos de biotransformação em frangos de corte

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Tissue persistence of fumonisin B1 in ducks and after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds

Cited by 16 publications

References 14 publications

Chronic Exposure to Deoxynivalenol Has No Influence on the Oral Bioavailability of Fumonisin B1 in Broiler Chickens

Chronic Exposure to Deoxynivalenol Has No Influence on the Oral Bioavailability of Fumonisin B1 in Broiler Chickens

Appropriateness to set a group health‐based guidance value for fumonisins and their modified forms

Efeitos da administração da aflatoxina, fumonisina e curcumina, isoladas ou associadas, sobre a resposta imunológica humoral e determinação de produtos de biotransformação em frangos de corte

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