2014
DOI: 10.1016/j.jab.2013.12.001
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Tissue profiling by nanogold-mediated mass spectrometry and artificial neural networks in the mouse model of human primary hyperoxaluria 1

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Cited by 12 publications
(11 citation statements)
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“…Clusters of monoisotopic elements provide simple spectra with many monoisotopic peaks covering the mass range of interest with regular mass spacing. In this work, we discuss the calibration of mass spectra by clusters of red phosphorus, which is already established in our laboratory [6,[10][11][12][13][14][15][16], and compare it with calibration by gold clusters generated directly on the target by laser desorption ionization (LDI)-MS of various materials, including gold foil [17], various types of gold nanoparticles (AuNPs), chloroauric acid (HAuCl 4 ), a mixture of 2-(4-hydroxyphenylazo) benzoic acid and HAuCl 4 [18], and polyvinylpyrrolidone-stabilized AuNPs [19]. Gold clusters provide simple and fast determination of accurate mass compared with common calibration standards, such as peptides or proteins.…”
Section: Introductionmentioning
confidence: 99%
“…Clusters of monoisotopic elements provide simple spectra with many monoisotopic peaks covering the mass range of interest with regular mass spacing. In this work, we discuss the calibration of mass spectra by clusters of red phosphorus, which is already established in our laboratory [6,[10][11][12][13][14][15][16], and compare it with calibration by gold clusters generated directly on the target by laser desorption ionization (LDI)-MS of various materials, including gold foil [17], various types of gold nanoparticles (AuNPs), chloroauric acid (HAuCl 4 ), a mixture of 2-(4-hydroxyphenylazo) benzoic acid and HAuCl 4 [18], and polyvinylpyrrolidone-stabilized AuNPs [19]. Gold clusters provide simple and fast determination of accurate mass compared with common calibration standards, such as peptides or proteins.…”
Section: Introductionmentioning
confidence: 99%
“…Alanine‐glyoxylate aminotransferase (AGXT) enzyme participates in alanine and aspartate metabolism. The two substrates of this enzyme are l ‐alanine and glyoxylate, while its two products are pyruvate and glycine (Houška et al, ). Glycine has also been suggested to promote innate immune responses (Schaumann et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…The intensities of the processed mass spectra served as the input, whereas the sample categories represented the output. The “ learning ” of the ANN was performed using the back‐propagation training algorithm as previously described . The back‐propagation was achieved by iteratively adjusting the values of the connection weights in order to minimize the difference between the ANN calculated output value and the experimental value.…”
Section: Methodsmentioning
confidence: 99%