Tissue Regeneration: The Dark Side of Opioids

Berthézène, Cécile Dromard; Rabiller, Lise; Jourdan, Géraldine; Cousin, Béatrice; Pénicaud, Luc; Casteilla, Louis; Lorsignol, Anne

doi:10.3390/ijms22147336

Cited by 10 publications

(3 citation statements)

References 106 publications

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“…In this context, it is possible that pain after injury plays a crucial role in promoting the proper re-maturation of healthy neuronal circuitry. Therefore, the excessive use of analgesics in clinical settings may potentially hinder regenerative outgrowth (74,75). The experience of pain may be a necessary part of the healing process; acknowledging and pursuing this hypothesis may lead to better outcomes.…”

Section: Drg Neuronal Plasticity Involves Alterations In Excitabilitymentioning

confidence: 99%

Plasticity of mouse dorsal root ganglion neurons by innate immune activation is influenced by electrophysiological activity

Friedman,

Lamothe,

Maguire

et al. 2024

Preprint

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Background. The intricate interplay between inflammation, its effects on neuronal excitability, and the ensuing plasticity of dorsal root ganglion (DRG) sensory neurons remains to be fully explored. In this study, we have investigated the impact of inflammatory conditioned media on the excitability and activity of DRG neurons and how this relates to subsequent growth responses of these cells. Findings. We show here that an early phase of increased neuronal activity in response to inflammatory conditioned media is critical for the engagement of plastic processes, and that neuronal excitability profiles are linked through time to the structural phenotype of individual neurons. Pharmacological blockade of neuronal activity was able to abolish the growth promoting effects of inflammatory media. Our findings also demonstrate a sex specificity of these responses. Conclusions. Our results suggest that targeting the activity of DRG neurons may provide a novel therapeutic avenue to manipulate their growth status and potential for plasticity in response to inflammation. While further studies are needed to fully elucidate the underlying mechanisms of the relationship between neural activity and growth status, a more complete understanding of this relationship may ultimately lead to the development of new treatments for neuropathic pain in disorders associated with heightened immune responses such as rheumatoid arthritis and MS.

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Section: Drg Neuronal Plasticity Involves Alterations In Excitabilitymentioning

confidence: 99%

Plasticity of mouse dorsal root ganglion neurons by innate immune activation is influenced by electrophysiological activity

Friedman,

Lamothe,

Maguire

et al. 2024

Preprint

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“…Early and transient ROS production and macrophage activity is required for regeneration as seen in animal studies. As a result, opioids, via their immunosuppressive effects, may inhibit the regeneration process [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic literature review of topical local anaesthesia or analgesia to donor site wounds

2022

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Background Topical local analgesic and anaesthetic agents have been used both pre- and immediately post-harvest on split-thickness skin graft (STSG) donor site wounds (DSW). There is no systematic review of their effectiveness in providing post-harvest analgesia, or of the possible toxic effects of systemic absorption. This study is designed to address the question of which agent, if any, is favoured over the others and whether there are any safety data regarding their use. Methods Systematic literature review of randomised controlled trials of topical agents applied to STSG DSWs, with a view to providing analgesia. Studies identified via search of Cochrane and EBSCO databases. No restrictions on language or publication year. Primary outcomes: pain at the time of (awake) STSG, and post-harvest pain (up to first dressing change). Secondary outcome was serum medication levels relative to published data on toxic doses. Cochrane risk of bias assessment tool utilised in assessment of included studies. At least 2 reviewers screened and reviewed included studies. A narrative review is presented. Results There were 11 studies meeting inclusion criteria. Overall methodological quality and patient numbers were low. Topical eutectic mixture of lidocaine and prilocaine pre-harvest affords good local anaesthesia in awake STSG harvesting. Topical bupivacaine (5 studies) or lidocaine (1 study) gave significantly better post-harvest anaesthesia/analgesia than placebo. Topical morphine performs no better than placebo. Topical local anaesthetic agents at reported doses were all well below toxic serum levels. Conclusions Topical local anaesthetics (lidocaine or bupivacaine) provide good analgesia, both during and after STSG harvest, at well below toxic serum levels, but there are no good data determining the best local anaesthetic agent to use. There is no evidence morphine performs better than placebo.

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“…Finally, Berthézène et al [19] addressed the intriguing issue of the role played by opioids in tissue regeneration. They focused their discussion on the complex dynamics occurring in damaged tissues, where the local patterning may progress up to the level of scar healing, highlighting the substantial difference (s) between this type of rescue and the true tissue regeneration.…”

mentioning

confidence: 99%

Special Issue of International Journal of Molecular Sciences “Opioid Receptors and Endorphinergic Systems 2.0”

Ventura

2021

IJMS

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Tissue Regeneration: The Dark Side of Opioids

Cited by 10 publications

References 106 publications

Plasticity of mouse dorsal root ganglion neurons by innate immune activation is influenced by electrophysiological activity

Plasticity of mouse dorsal root ganglion neurons by innate immune activation is influenced by electrophysiological activity

Systematic literature review of topical local anaesthesia or analgesia to donor site wounds

Special Issue of International Journal of Molecular Sciences “Opioid Receptors and Endorphinergic Systems 2.0”

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