Tissue-Resident Lymphocytes in the Kidney

Turner, Jan-Eric; Becker, Mies J.; Mittrücker, Hans‐Willi; Panzer, Ulf

doi:10.1681/asn.2017060599

Cited by 70 publications

(54 citation statements)

References 86 publications

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“…A specific population of interest are tissue-resident NK cells, which can reside in tissue for years and execute local tasks. Studies of tissue-resident NK cells from human livers [ 7 – 10 ], lungs [ 10 , 11 ], lymph nodes [ 12 , 13 ], uterus [ 14 ], kidneys [ 15 ] and spleens [ 13 , 16 ] have elucidated how tissue-resident NK cells are distinct from NK cells circulating in the peripheral blood, showing crucial differences in phenotypical and functional characteristics.…”

Section: Introductionmentioning

confidence: 99%

Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71

et al. 2018

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Metabolism is a critical basis for immune cell functionality. It was recently shown that NK cell subsets from peripheral blood modulate their expression of nutrient receptors following cytokine stimulation, demonstrating that NK cells can adjust to changes in metabolic requirements. As nutrient availability in blood and tissues can significantly differ, we examined NK cells isolated from paired blood-liver and blood-spleen samples and compared expression of the nutrient transporters Glut1, CD98 and CD71. CD56bright tissue-resident (CXCR6+) NK cells derived from livers and spleens expressed lower levels of Glut1 but higher levels of the amino acid transporter CD98 following stimulation than CD56bright NK cells from peripheral blood. In line with that, CD56dim NK cells, which constitute the main NK cell population in the peripheral blood, expressed higher levels of Glut1 and lower levels of CD98 and CD71 compared to liver CD56bright NK cells. Our results show that NK cells from peripheral blood differ from liver- and spleen-resident NK cells in the expression profile of nutrient transporters, consistent with a cell-adaptation to the different nutritional environment in these compartments.

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Section: Introductionmentioning

confidence: 99%

Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71

et al. 2018

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“…To our knowledge, this is the first study which demonstrates the profile of ILC subsets in AKI. Previous studies have focused on therapeutic modula-tion of type 2 immunity, via maneuvers to amplify ILC2s, on the outcome of AKI [22]. Huang et al [31] showed that Il-25-treated mice subjected to renal IRI display increased serum levels of IL-4, IL-5, and IL-13 in association with increased frequencies of ILC2s and improved renal function.…”

Section: Discussionmentioning

confidence: 99%

“…This property likely contributes to the important roles of ILCs not only in immune responses against pathogens and sterile inflammation but also in maintaining tissue hemostasis. Nonetheless, differential development and activation of ILCs in a context-and/or disease-specific manner may contribute to inflammatory responses and/or outcome of treatment modalities [20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ

Baban

Khodadadi

Vaibhav

et al. 2020

Journal of Immunology Research

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Innate lymphoid cells (ILCs) have emerged as largely tissue-resident archetypal cells of the immune system. We tested the hypotheses that renal ischemia-reperfusion injury (IRI) is a contributing factor to polarization of ILCs and that glucocorticoid-induced leucine zipper (GILZ) and cannabidiol regulate them in this condition. Mice subjected to unilateral renal IRI were treated with the following agents before restoration of renal blood flow: cannabidiol, DMSO, transactivator of transcription- (TAT-) GILZ, or the TAT peptide. Thereafter, kidney cells were prepared for flow cytometry analyses. Sham kidneys treated with either cannabidiol or TAT-GILZ displayed similar frequencies of each subset of ILCs compared to DMSO or TAT, respectively. Renal IRI increased ILC1s and ILC3s but reduced ILC2s compared to the sham group. Cannabidiol or TAT-GILZ treatment of IRI kidneys reversed this pattern as evidenced by reduced ILC1s and ILC3s but increased ILC2s compared to their DMSO- or TAT-treated counterparts. While TAT-GILZ treatment did not significantly affect cells positive for cannabinoid receptors subtype 2 (CB2+), cannabidiol treatment increased frequency of both CB2+ and GILZ-positive (GILZ+) cells of IRI kidneys. Subsequent studies showed that IRI reduced GILZ+ subsets of ILCs, an effect less marked for ILC2s. Treatment with cannabidiol increased frequencies of each subset of GILZ+ ILCs, but the effect was more marked for ILC2s. Indeed, cannabidiol treatment increased CB2+ GILZ+ ILC2s. Collectively, the results indicate that both cannabidiol and GILZ regulate ILC frequency and phenotype, in acute kidney injury, and that the effects of cannabidiol likely relate to modulation of endogenous GILZ.

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“…[ 19 ] Similarly, kidney possesses NKT cells, MAIT cells, and γδ T cells. [ 20 ] CNS consists of macrophages‐like cells known as microglia along with monocytes, dendritic cells, natural killer (NK) cells, T cells, and B cells. [ 21 ] Similarly, immune cells residing in the adipose tissue include eosinophils, anti‐inflammatory M2 macrophages, and type 2 innate lymphoid cells.…”

Section: Introductionmentioning

confidence: 99%

3D Immunocompetent Organ‐on‐a‐Chip Models

2020

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In recent years, engineering of various human tissues in microphysiologically relevant platforms, known as organs‐on‐chips (OOCs), are explored to establish in vitro tissue models that recapitulate the microenvironments found in native organs and tissues. However, most of these models have overlooked the important roles of immune cells in maintaining tissue homeostasis under physiological conditions and in modulating the tissue microenvironments during pathophysiology. Significantly, gradual progress is being made in the development of more sophisticated microphysiologically relevant human‐based OOC models that allow the studies of the key biophysiological aspects of specific tissues or organs, interactions between cells (parenchymal, vascular, and immune cells) and their extracellular matrix molecules, effects of native tissue architectures (geometry, dynamic flow, or mechanical forces) on tissue functions, as well as unravelling the mechanism underlying tissue‐specific diseases and drug testing. In this progress report, the different components of the immune system, as well as immune OOC platforms and immunocompetent OOC approaches that have simulated one or more components of the immune system, are discussed. The challenges to recreate a fully functional tissue system in vitro with a focus on the incorporation of the immune system are also outlined.

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Tissue-Resident Lymphocytes in the Kidney

Cited by 70 publications

References 86 publications

Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71

Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71

Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ

3D Immunocompetent Organ‐on‐a‐Chip Models

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