Tissue Sites of Uptake of14C-Labeled C60

Bullard-Dillard, Rebecca; Creek, Kim E.; Scrivens, Walter A.; Tour, James M.

doi:10.1006/bioo.1996.0032

Cited by 110 publications

(78 citation statements)

References 17 publications

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“…Another specialized technique used to quantify CNTs in soils, sediments, and biological tissues and fullerenes in biological tissues is radioactive labeling [27,41,42,90,[96][97][98][99]. Some studies have indicated that biological oxidation of MWNTs and SWNTs in soils, sediments, and tissues was needed to avoid artifacts related to the self-quenching: beta emissions from 14 C were absorbed by the NP aggregates [41,42], whereas another study did not find this effect [27].…”

Section: Methods Of Cnp Analysis In Other Matricesmentioning

confidence: 99%

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Petersen

Henry

2011

Enviro Toxic and Chemistry

114

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Abstract-The recent emergence of manufactured nanoparticles (NPs) that are released into the environment and lead to exposure in organisms has accelerated the need to determine NP toxicity. Techniques for measuring the toxicity of NPs (nanotoxicology) in ecological receptors (nanoecotoxicology) are in their infancy, however, and establishing standardized ecotoxicity tests for NPs are presently limited by several factors. These factors include the extent of NP characterization necessary (or possible) before, during, and after toxicity tests such that toxic effects can be related to physicochemical characteristics of NPs; determining uptake and distribution of NPs within exposed organisms (does uptake occur or are effects exerted at organism surfaces?); and determining the appropriate types of controls to incorporate into ecotoxicity tests with NPs. In this review, the authors focus on the important elements of measuring the ecotoxicity of carbon NPs (CNPs) and make recommendations for ecotoxicology testing that should enable more rigorous interpretations of collected data and interlaboratory comparisons. This review is intended to serve as a next step toward developing standardized tests that can be incorporated into a regulatory framework for CNPs. Environ. Toxicol. Chem.

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Section: Methods Of Cnp Analysis In Other Matricesmentioning

confidence: 99%

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Petersen

Henry

2011

Enviro Toxic and Chemistry

114

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“…Znakowany izotopowo fuleren C 60 podany dożylnie szczurom został wyeliminowany z układu krwionośnego w przeciągu 1 min [23]. Większość podanej dawki (90-95%) wykryto w wątrobie.…”

Section: Toksykokinetyka Fulerenu I Jego Pochodnychunclassified

“…Po upły-wie 5 dni obserwacji fuleren nadal był wykrywany w tym narządzie. Wyniki wskazują, że fuleren nie ulega metabolizmowi na szlaku oksydacyjnym, jak policykliczne węglowodory aromatyczne, ale może długo kumulować się w wątrobie [23].…”

Section: Toksykokinetyka Fulerenu I Jego Pochodnychunclassified

Fullerenes: Characteristics of the substance, biological effects and occupational exposure levels

Świdwińska-Gajewska

Czerczak

2016

Med Pr

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StreszczenieFulereny są cząsteczkami złożonymi z parzystej liczby atomów węgla o sferycznej, kulistej lub elipsoidalnej, zamkniętej strukturze przestrzennej. Najbardziej popularnym fulerenem jest cząsteczka C 60 o kulistej budowie -ściętego dwudziestościanu foremnego, przypominającego piłkę nożną. Fulereny znajdują szerokie zastosowanie przede wszystkim w diagnostyce i medycynie, ale również w przemyśle elektronicznym i energetycznym. Narażenie zawodowe na fuleren może wystąpić głównie przy jego produkcji. Stężenia w środowisku pracy fulerenów, opisane w literaturze, wynosiły 0,12-1,2 µ/m 3 dla frakcji nanocząstek (< 100 nm), co może świadczyć o niewielkim narażeniu. Fuleren jednak w dużej części aglomeruje do większych cząstek. Wchłanianie fulerenu drogą pokarmową i oddechową jest niewielkie oraz nie jest on absorbowany przez skórę. Po podaniu dożylnym fuleren może kumulować się w wątrobie oraz w mniejszym stopniu w śledzionie lub nerkach. Nie obserwowano działania fulerenu drażniące-go ani uczulającego na skórę w badaniach na zwierzętach, jedynie słabe działanie drażniące na oczy. W badaniach inhalacyjnych na gryzoniach fuleren wywoływał przejściowe zmiany zapalne w płucach. Narażenie drogą pokarmową nie wywoływało więk-szych negatywnych skutków. Fuleren nie wykazywał działania mutagennego ani genotoksycznego w badaniach eksperymentalnych. Nie ma opublikowanych danych dotyczących rakotwórczego działania nanocząstek fulerenu u ludzi i zwierząt. Istnieją natomiast doniesienia o możliwym szkodliwym wpływie fulerenu na płód u myszy po podaniu dootrzewnowym lub dożylnym. Fuleren w czystej postaci charakteryzuje się słabym wchłanianiem i niską toksycznością oraz nie stanowi zagrożenia w środowi-sku pracy. Autorzy niniejszej pracy stoją na stanowisku, że nie ma podstaw do wyznaczenia najwyższego dopuszczalnego stęże-nia (NDS) fulerenu C 60 w niezmodyfikowanej formie. Pochodne fulerenów, z uwagi na odmienne właściwości, wymagają osobnej analizy pod względem szacowania ryzyka zawodowego. Med. Pr. 2016;67(3):397-410 Słowa kluczowe: nanocząstki, narażenie zawodowe, najwyższe dopuszczalne stężenie, nanomateriały, wartości dopuszczalnych stężeń, fuleren AbstractFullerenes are molecules composed of an even number of carbon atoms of a spherical or an ellipsoidal, closed spatial structure. The most common fullerene is the C 60 molecule with a spherical structure -a truncated icosahedron, compared to a football. Fullerenes are widely used in the diagnostics and medicine, but also in the electronics and energy industry. Occupational exposure to fullerene may occur during its production. The occupational concentrations of fullerenes reached 0.12-1.2 µ/m 3 for nanoparticles fraction (< 100 nm), which may evidence low exposure levels. However, fullerene mostly agglomerates into larger particles. Absorption of fullerene by oral and respiratory routes is low, and it is not absorbed by skin. After intravenous administration, fullerene accumulates mainly in the liver but also in the spleen and the kidneys. In animal experiments there ...

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“…The percentage of airborne C 60 nanoparticles deposited on the alveolar area and their transport from the lungs to the other organs have been calculated using the aerosol deposition model and the analysis of the kinetics. In some reports, C 60 particles were detected in the liver and spleen after intraperitoneal or intravenous injection [46][47][48] , but there are no reports on the translocation of C 60 particles to the brain. Clearance of C 60 from the blood after an intravenous injection was extremely fast, taking place within 1 min, and most of cleared C 60 was accumulated in the liver, where it remained for over 120 h 48) .…”

Section: Fullerenesmentioning

confidence: 99%

“…In some reports, C 60 particles were detected in the liver and spleen after intraperitoneal or intravenous injection [46][47][48] , but there are no reports on the translocation of C 60 particles to the brain. Clearance of C 60 from the blood after an intravenous injection was extremely fast, taking place within 1 min, and most of cleared C 60 was accumulated in the liver, where it remained for over 120 h 48) . In the NEDO project intratracheal instillation and inhalation exposure studies on rat have been performed using C 60 suspension stably dispersed as nanoparticle (90%ile particle size based on volume: <100 nm).…”

Section: Fullerenesmentioning

confidence: 99%

Hazard Assessments of Manufactured Nanomaterials

Morimoto

Kobayashi

Shinohara

et al. 2010

Journal of Occupational Health

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Hazard Assessments of Manufactured Nanomaterials: Yasuo MORIMOTO, et al. Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, JapanBackground: It has been difficult to make reliable hazard assessments of manufactured nanomaterials, because the nanomaterials form large agglomerations in both in vitro and in vivo studies. Objective: In the New Energy and Industrial Technology Development Organization (NEDO) Project of Japan, the physicochemical properties of many manufactured nanomaterials are being measured, and in vitro and in vivo studies are being performed to determine which endpoints are correspond to the hazards and risks of nanomaterials. Focusing on titanium dioxide, fullerenes and carbon nanotubes, we introduce findings made in inhalation and intratracheal installation studies overseas, and together with the findings made in the NEDO project, and also assess the hazards presented by manufactured nanomaterials. Results and Conclusion : A project by NEDO has succeeded in ensuring the stability of dispersion (nanoscale <100 nm) of manufactured nanomaterials, and is developing hazard assessments of manufactured nanomaterials. In these interim reports, the acceptable exposure concentration of titanium dioxide and fullerene was proposed to be 1.2 mg/m 3 and 0.8 mg/m 3 respirable dust in working environment, respectively. (J Occup Health 2010; 52: 325-334)

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Tissue Sites of Uptake of14C-Labeled C60

Cited by 110 publications

References 17 publications

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Fullerenes: Characteristics of the substance, biological effects and occupational exposure levels

Hazard Assessments of Manufactured Nanomaterials

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