Tissue-specific accumulation, elimination, and toxicokinetics of illicit drugs in adult zebrafish (Danio rerio)

Assessment of wastewater-borne pharmaceuticals in tissues and body fluids from riverine fish

“…1). In this sense, it would be expected that the highest concentrations for these compounds would be in the brain, as previously reported (Grabicová et al, 2020(Grabicová et al, , 2014Lajeunesse et al, 2011;McCallum et al, 2017;Tanoue et al, 2015;Yin et al, 2021). However, our results do not follow this trend, only fulfilled for venlafaxine in the thinlip mullet, which a mean concentration in the brain of 88 ng g − 1 , was the highest reported in our manuscript.…”

“…Studies of PhACs analysis in wild fish and fish exposed to different concentrations of PhACs have shown that the liver tends to have a higher accumulation of compounds compared to other tissues (Grabicová et al, 2020(Grabicová et al, , 2017Vaclavik et al, 2020;Xie et al, 2015;Yin et al, 2021). This could be related to the liver being the main metabolizing organ in fish (Yin et al, 2021). Here the detoxification processes are led (Miller et al, 2018) because it is the leading site where the cytochrome P450 (CYP450) enzymes that metabolize PhACs in fish are produced.…”

Bis(2-ethylhexyl)-tetrabromophthalate Poses a Higher Exposure Risk and Induces Gender-Specific Metabolic Disruptions in Zebrafish Liver

“…We used the classical pseudo-first-order toxicokinetic model to perform uptake and elimination toxicokinetic analysis based on average concentrations in each sample at various time points. ,, We used the software Origin2021 (OriginLab, Northampton) to perform nonlinear fitting . In nonlinear fitting, a common practice is to use the least-squares method to optimize parameters and fit the data.…”

Development of a USE/d-SPE and targeted DIA-Orbitrap-MS acquisition methodology for the analysis of wastewater-derived organic pollutants in fish tissues and body fluids

“…In the heart and in the liver, no compound was recovered a percentage greater than 90% for any of the validation levels. In the case of the liver, the low recoveries may be associated with the fact that this organ, which is the main metabolic organ of fish [ 13 , 14 ], has a higher lipid content than in the whole body homogenates [ 15 , 16 ] and retains a greater amount of blood [17] . The heart also has a high blood content which interferes with the suppression of the analyte signal, as can be seen in Fig.…”