Tissue‐specific migration pathways by phenotypically distinct subpopulations of memory T cells

Mackay, Charles R.; Marston, Wendy L.; Dudler, Lisbeth; Spertini, Olivier; Tedder, Thomas F.; Hein, Wayne R.

doi:10.1002/eji.1830220402

Cited by 237 publications

(137 citation statements)

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“…retransfusion [74]. Naïve and memory lymphocytes were analysed in sheep and their tissue specific immigration was obvious [41][42][43]. Based on these experiments, the concept about naïve and memory T cells was clarified.…”

Section: Important Intestine-related Lymphocyte Migration Studies In mentioning

confidence: 99%

“…Expression of α4β7-integrin has been demonstrated on memory T cells of sheep which migrate through intestinal lymph nodes and PP [41]. Likewise, high levels of α4β7-integrin were detected on lymphocytes in ovine intestinal lymph, whereas expression in peripheral or pulmonary lymph was low [1,42]. MAdCAM-1 was detected at high levels on HEV of mesenteric lymph nodes and PP as well as on postcapillary venules of the intestinal lamina propria, whilst tonsils and peripheral lymph nodes were only weakly positive [41,66].…”

Section: Regulation Of Lymphocyte Migrationmentioning

confidence: 99%

“…In contrast to MAdCAM-1, L-selectin preferentially directs the migration of lymphocytes into peripheral lymph nodes [15]. High L-selectin expression is seen on naïve T cells migrating to ovine peripheral nodes [1,42], whereas lymphocytes isolated from bovine PP are L-selectin low [15]. The L-selectin receptor, peripheral lymph node addressin (PNAd), is predominantly found on HEV of peripheral lymph nodes and tonsils [14,66], but also in BALT of sheep with airway hyperresponsiveness, where PNAd is also involved in lymphocyte entry into the bronchoalveolar space [73].…”

Section: Regulation Of Lymphocyte Migrationmentioning

confidence: 99%

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Lymphocyte migration studies

Bimczok

Rothkötter

2006

Vet. Res.

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-For maintenance of immunity and tolerance, the organs and tissues of the organism are connected by migrating lymphoid cells. Understanding lymphocyte migration is essential for many disorders and diseases -especially in the mucosa-lined organs. Detailed analyses of migrating lymphocytes have been performed in many species, especially in laboratory animals. However, important experiments in lymphocyte migration have been carried out in large animals, for example sheep, cattle and pigs. These species allow experimental procedures like in situ-organ labelling, lymphocyte retransfusion studies or lymph vessel cannulations. Such studies have made an important contribution to the understanding of the overall principles of lymphocyte migration especially in the mucosal immune system. Major results on the specific migration of naïve and memory T cells through lymphoid organs, the re-distribution of γ/δ T cells in the intestinal immune system and the emigration of newly produced B cells from the ileal Peyer's patches have been obtained in large animals. Since there are growing numbers of markers for large animals, and molecular biology methods are available in these species, experiments in large animals will be an essential tool for the understanding of lymphocyte migration especially in mucosal organs.

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Section: Important Intestine-related Lymphocyte Migration Studies In mentioning

confidence: 99%

Section: Regulation Of Lymphocyte Migrationmentioning

confidence: 99%

Section: Regulation Of Lymphocyte Migrationmentioning

confidence: 99%

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Lymphocyte migration studies

Bimczok

Rothkötter

2006

Vet. Res.

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“…All mAbs used in this study have been described previously: IL-A42, anti-bovine CD2 [15]; IL-A11, anti-bovine CD4 [4]; IL-A51, anti-bovine CD8 [17]; R15.7, anti-canine CD18 cross reactive with bovine CD18 [6,18]; BII 218.1, antisheep CD49d crossreactive with bovine cells [25]. UD15 directed against chloramphenicol [39] served as negative control.…”

Section: Cell Surface Phenotyping By Flow Cytometrymentioning

confidence: 99%

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

et al. 2004

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-Dexamethasone is a potent therapeutic for treatment of the fatty liver syndrome or primary ketosis in post partum dairy cows. Reservations exist, however, among practitioners with respect to the risk of immunosuppression induced by corticosteroids. The aim of this study was to investigate the effect of a single injection of dexamethasone-21-isonicotinate on distinct immune functions of postpartum dairy cows because only scarce information is available on the effects of corticosteroid preparations when administered at a dosage and frequency for treatment of the fatty liver syndrome or primary ketosis. Sixteen Swedish red-pied dairy cows, between days 9 and 15 post partum, were allotted to either a control group (n = 8) or a treatment group (n = 8). The cows in the treatment group received a single intramuscular injection of a dexamethasone-21-isonicotinate suspension at a dosage of 0.02 mg/kg i.m. at the start of the experiment. White blood cell counts and selected lymphocyte functions (lymphocyte proliferation, expression of lymphocyte markers and the β2 and α4 chain of adhesion molecules belonging to the integrin family) and some parameters of the energy metabolism (glucose, insulin) were determined before the administration of corticosteroids (day 0) and subsequently at days 2, 4, 7 and 9 of the experiment. Changes in glucose and insulin were within the target range for treatment of the fatty liver syndrome or primary ketosis. Significant (P < 0.05) increases in the number of circulating white blood cells were observed in treated cows on the second day following treatment which was exclusively caused by an increase in the number of circulating neutrophils. Lymphocyte blastogenesis in response to ConA and the percentages of lymphocytes positive for CD2, CD4, CD8, CD49d and CD18 as well as the intensity of CD49d expression did not differ between the treatment and control groups. There was, however, a significant reduction (P < 0.01) in the intensity of CD18 expression on lymphocytes in the treated animals on the fourth day after treatment. In conclusion, a single administration of dexamethasone-21-isonicotinate in a dosage of 0.02 mg/kg i.m. at two weeks post partum in healthy cows had a significant but highly transient effect on CD18 expression on lymphocytes and the number of peripheral blood neutrophils, but did not affect lymphocyte blastogenesis or lymphocyte subpopulation patterns in peripheral blood.

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“…Previous experiments have indicated that memory CD4 ϩ T cells are largely responsible for tissue-specific recirculation patterns observed using recirculating ELLs in vivo (23,26,27). To test for the possibility that a single lymphocyte subset was responsible for the observed tissue-specific homing patterns of PBLs, labeled lymphocytes were collected from efferent intestinal or s.c. lymph at 12, 24, and 36 h after i.v.…”

Section: ␥␦-T Cells Are the Major Recirculating Populationmentioning

confidence: 99%

Subset-Specific Regulation of the Lymphatic Exit of Recirculating Lymphocytes In Vivo

Young¹,

Marston²,

Dudler³

2000

The Journal of Immunology

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The blood-to-lymph recirculation of lymphocytes is required for the maintenance of immune surveillance and the dissemination of memory. Although the ability of lymph-borne cells to recirculate has been well documented, relatively less is known about the migration capacity of PBLs. We have found a clear preference for PBLs to recirculate through s.c. rather than intestinal lymph nodes. This preference could be directly attributed to the migratory characteristics of γδ-T cells. γδ-T cells were found to express significantly higher levels of L-selectin than other subsets, suggesting that at least some of this preferential migration could be attributed to their interaction with ligands on vascular endothelium. More detailed experiments showed that γδ-T cells migrated through lymph nodes with greater efficiency than αβ T cells or B cells, which clearly indicated an enhanced ability of γδ-T cells to exit lymph nodes in the efferent lymph independent of entry from the blood. This hypothesis was supported by histological examination, where γδ-T cells were found almost exclusively in the interfollicular traffic areas within lymph nodes. These data indicate that γδ-T cells are the most active recirculating lymphocyte subset in ruminants and suggest new mechanisms to regulate the traffic of lymphocyte subsets through normal lymph nodes.

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Tissue‐specific migration pathways by phenotypically distinct subpopulations of memory T cells

Cited by 237 publications

References 48 publications

Lymphocyte migration studies

Lymphocyte migration studies

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

Subset-Specific Regulation of the Lymphatic Exit of Recirculating Lymphocytes In Vivo

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