Tissue-specific toxicity of clothianidin on rainbow trout (<i>Oncorhynchus mykiss</i>)

Dogan, Demet; Nur, Gökhan; Deveci, Hacı

doi:10.1080/01480545.2021.1892128

Cited by 14 publications

(3 citation statements)

References 61 publications

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“…Pericellular edema and necrosis, Purkinje cell degeneration, cell infiltration, congestion, gliosis, vascular dilatation and dystrophic changes were detected in the brain tissue. In kidney tissue, glomerular atrophy, decrease in hematopoietic tissue cells, tubular degeneration, and an increase in the number and spread of melanomacrophage centers depending on the increasing dose of clothianidin were observed [26].…”

Section: Histopathological Effects Of Insecticidesmentioning

confidence: 98%

An Overview of the Biochemical and Histopathological Effects of Insecticides

Deveci¹,

Nur²,

Deveci³

et al. 2022

Insecticides - Impact and Benefits of Its Use for Humanity

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The number of studies on insecticides, which constitute an important class of pesticides, is increasing day by day. These chemicals used in the fight against pests in the field of agriculture; It is also used to fight mosquitoes and insects in homes, gardens and rural areas. Excessive use of insecticides has adversely affected many beneficial organisms besides target organisms. As a result of the negative effects of insecticides on non-target organisms, the normal balance of nature has been disturbed and this has led to the decline of some living species in the world. In many studies from the past to the present, it has been shown that these insecticides have negative effects on the environment, human and animal health. Some of these chemicals, which have many benefits in the fight against agricultural pests, have been banned due to their harmful effects on non-target organisms as a result of excessive use. Today, however, these chemicals are still used intensively against agricultural pests, threatening non-target organisms and human health. For this reason, in this book chapter we have prepared, the negative effects of insecticides on living things are examined by reviewing biochemical and histopathological studies.

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Section: Histopathological Effects Of Insecticidesmentioning

confidence: 98%

An Overview of the Biochemical and Histopathological Effects of Insecticides

Deveci¹,

Nur²,

Deveci³

et al. 2022

Insecticides - Impact and Benefits of Its Use for Humanity

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show abstract

“…The chemicals had a considerable impact on the gills of treated groups, causing hypertrophy, hyperplasia, secondary lamellae shortening and fusion, edema, lamellae curling, and epithelial lifting. Tissue-specific toxicity of clothianidin on rainbow trout caused fusion and shortening of secondary lamellae, hypertrophy of secondary lamellae, and necrosis of secondary lamellae [38] . Changes in the structure including secondary lamellae curling, epithelial lifting, hyperplasia, and lamella fusing were reported in Sparus aurata subjected to erythromycin and oxytetracycline [39] .…”

Section: Table 1: Lc 50 Of Egcg and C-pc For Various Duration (24 H 4...mentioning

confidence: 99%

Acute Toxicity of Epigallocatechin Gallate and C-Phycocyanin in Zebrafish (Danio rerio): Behavioral and Histopathological Studies

Jamir,

Longkumer,

Punj

2024

IJPS

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Acute Toxicity of Epigallocatechin Gallate and C-Phycocyanin in ZebrafishEpigallocatechin gallate and C-phycocyanin are natural food supplements, gaining a lot of popularity in biomedical researches. The lethal concentration 50 value for the zebrafish model was determined using a 96 h semi-static acute toxicity test. Zebrafish were transferred into a 1 l water tank starting with a minimal dose of 8 mg of epigallocatechin gallate and 1 g of C-phycocyanin, which further increased to the concentration of 30 mg for epigallocatechin gallate and 5 g for C-phycocyanin. Lethal concentration 50 of epigallocatechin gallate and C-phycocyanin was calculated to be 21.37 mg/l and 2.45 g/l respectively at 96 h in the zebrafish model. At high doses above 12 mg of epigallocatechin gallate and 1 g of C-phycocyanin, the test fish displayed various behavior responses like erratic and jerky swimming, attempts to jump out of the water, frequent surfacing and swallowing of air, normal skin color change, decreased opercular movement and finally leading to death. Histological observations showed hypertrophy, atrophy and vacuolar degeneration in the liver whereas tubular degeneration, glomerular hyper cellularity, dilation of Bowman's space, hemorrhage, and necrosis were observed in the kidneys exposed to the high doses of epigallocatechin gallate and C-phycocyanin treated fish. The gills of the test animals also expressed lamellar synechiae, hyperplasia, curling of lamellae, mucus secretion and shortening of the secondary lamella. The results demonstrated that doses above 30 mg/l and 5 g/l in the case of epigallocatechin gallate and C-phycocyanin respectively gave 100 % mortality and expressed organ-specific toxicity. Overall results revealed that exposure to high concentrations of epigallocatechin gallate and C-phycocyanin uninterruptedly may lead to severe alterations in the tissue of experimental animals.

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“…Besides insects and other agricultural pests, the organisms on which it is primarily effective, unfortunately, also pose toxic effects on animals and humans at different levels. These effects vary depending on the dose and exposure level and the body's resistance (Toghan et al, 2022;Dogan et al, 2022;Deveci et al, 2021;Nur et al, 2021). Neonicotinoids are a class of pesticides consisting of nicotine-based compounds that are widely and successfully used against agricultural and household pests.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Acetamiprid Administration on Bcl-2 Immunoreactivity in the Liver

Nur

2024

Turkish JAF Sci.Tech.

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This study aimed to show the effect of acetamiprid, a neonicotinoid insecticide, on B-cell lymphoma 2 (Bcl-2) gene expression, which plays an important role in apoptotic mechanisms in liver tissue. The study consisted of four groups in total, in which three doses of acetamiprid (5, 10, and 15 mg kg-1) were administered, together with the negative group, in which no substance was administered. Liver tissues resected from mice sacrificed by cervical dislocation after 14 days of acetamiprid administration by gavage were fixed in a 10% formaldehyde solution for histological and immunohistochemical analyses and blocked in paraffin after routine tissue follow-up, and sections were stained with haematoxylin-eosin and immunostaining. Histological analysis revealed normal liver tissue in the control group; whereas, sinusoidal dilatation, vasodilatation, and necrosis and steatosis in the parenchyma were found in the acetamiprid-treated group at an increasing rate depending on the dose amount. The immunoreactivity of Bcl-2 in liver tissue was observed in the sinusoidal epithelium. Bcl-2 immunoreactivity was observed severely in the control and 5 mg kg-1 groups and moderately in the 10 mg kg-1 and 15 mg kg-1 acetamiprid-treated groups. Bcl-2 immunoreactivity was observed homogenously in the region from the central vein to the Kiernan’s space. It was observed that acetamiprid used in the study showed a toxic effect on liver tissue, affected bcl-2 expression, an important biomarker in apoptotic pathways, and induced a dose-dependent decrease in bcl-2 immunoreactivity.

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Tissue-specific toxicity of clothianidin on rainbow trout (Oncorhynchus mykiss)

Cited by 14 publications

References 61 publications

An Overview of the Biochemical and Histopathological Effects of Insecticides

An Overview of the Biochemical and Histopathological Effects of Insecticides

Acute Toxicity of Epigallocatechin Gallate and C-Phycocyanin in Zebrafish (Danio rerio): Behavioral and Histopathological Studies

The Effect of Acetamiprid Administration on Bcl-2 Immunoreactivity in the Liver

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