Tissue-specificity of proteoglycans expression in different cancers

Abstract

Background. Proteoglycans (PGs) are complex glycosylated molecules playing an important role in cell-cell and cell-matrix interactions and signaling. Expression of PGs and their expression pattern change considerably during malignant transformation of mammalian cells and tissues.Objective. The aim of our work was to investigate tissue-specificity of main PGs expression perlecan, aggrecan, versican, CSPG4/NG2, brevican, decorin, lumican)