Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients

Sicilia, Alberto; Cuesta, Susana; Coma, Gerardo; Arregui, Ignacio; Guisasola, Cristina; Ruiz, Eduardo Montero; Maestro, A.

doi:10.1111/j.1600-0501.2008.01544.x

Cited by 374 publications

(326 citation statements)

References 54 publications

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“…There are, however, esthetic problems associated with the Ti implants due to its gray coloring. Moreover, since Ti originally having the characteristics of biotolerant which cause ion elution by corrosion in some environments, Ti implants have been reported to trigger allergic reactions [1][2][3] . Recently zirconia has drawn attention as a potential alternative to Ti, as it allows both allergic reactions and esthetic problems to be avoided 4,5) .…”

Section: Introductionmentioning

confidence: 99%

Initial attachment of human oral keratinocytes cultured on zirconia or titanium

et al. 2012

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Initial attachment of human oral keratinocytes (HOKs) cultured on mirror-surfaced commercially pure titanium (Ti) or yttriastabilized tetragonal zirconia polycrystals (TZP) was investigated. Numbers of viable attached HOKs, their mRNAs and proteins expression of laminin γ2 and integrin β4 were evaluated using the WST-1 assay, quantitative real-time PCR and enzyme-linked immunosorbent assay, respectively. Localization of laminin γ2 and integrin β4 was observed using immunofluorescent staining. Cell spreading was evaluated by measuring the perimeter of actin on fluorescent stained images, and cell morphology was examined using scanning electron microscopy. At 1 h TZP elicited less of initial attachment than Ti in terms of mRNAs expression and proteins expression of laminin γ2 and integrin β4 (p<0.05). However, at 48 h TZP was showed similar initial attachment in comparison to Ti. Therefore, it was suggested that TZP has a potential to form epithelial attachment like Ti.

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Section: Introductionmentioning

confidence: 99%

Initial attachment of human oral keratinocytes cultured on zirconia or titanium

et al. 2012

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“…Les auteurs concluent qu'il faut y penser et la rechercher chez les patients souffrant de symptômes d'allergie après une implantation mais aussi devant un échec implantaire inexpliqué et répété [34].…”

Section: Allergie Au Titaneunclassified

Allergènes en chirurgie bucco-dentaire

Kissi

Yahya

2012

Med Buccale Chir Buccale

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Résumé -En chirurgie bucco-dentaire, le praticien, le personnel et les patients sont de plus en plus confrontés à des phénomènes d'allergie et d'intolérance. Ces phénomènes sont fréquents et leur prévalence a tendance à s'accroitre principalement à cause de la diversité et de la multiplication des produits allergisants qui sont manipulés. Les allergènes responsables ne sont pas toujours bien documentés. Parmi ces allergènes, le latex est le plus fréquemment cité dans la littérature et les réactions allergiques ont une prévalence variant entre 2,8 % à 16,9 % chez les professionnels de santé. Il serait responsable d'allergies cutanées et respiratoires de plus en plus fréquentes. Il est ainsi devenu une source de préoccupations pour les allergologues d'où l'intérêt de bien définir les allergènes responsables, les facteurs déclenchants, le pouvoir pathogène ainsi que les différentes expressions cliniques de cette allergie. Les matériaux prothétiques manipulés par le chirurgien dentiste et le prothésiste, notamment les résines acryliques et certains matériaux d'empreinte ainsi que les métaux (nickel, cobalt, chrome, or) ont été également incriminés dans la survenue des manifestations allergiques. Le titane, métal considéré comme ayant une excellente biocompatibilité, a également fait l'objet de nombreuses publications, ces dernières années, montrant son rôle dans la survenue de réactions allergiques. Rarement, les antiseptiques utilisés en pré-opératoire ainsi que certains désinfectants peuvent être responsables d'intolérance ou de sensibilisation de contact. Enfin, les anesthésiques locaux sont incriminés, souvent de façon abusive, dans des manifestations considérées comme des réactions allergiques. Les réactions allergiques peuvent être banales à type d'érythème muqueux chez les patients ou à type d'urticaire, voire d'eczéma cutané chez les praticiens et le personnel, mais elles peuvent prendre d'autres formes : oedéme de Quincke pour le latex, échec implantaire inexpliqué. La difficulté principale réside dans la recherche de l'étiologie de ces accidents allergiques. L'interrogatoire est d'une grande importance pour poser le diagnostic, pour dépister les patients à risque mais également pour mettre en oeuvre les moyens de prévention ; toutes ces démarches doivent être effectuées en étroite collaboration avec l'allergologue.Abstract -Allergens in dentistery. In dentistry, the dentist, the staff and the patients are increasingly confronted with the phenomenon of allergy and intolerance. These are common and their prevalence tends to increase because such diversity and multiplication of allergenic products that are handled. The allergens involved are unfortunately poorly documented. Among these allergens, latex is the most frequently reported in the literature and can cause allergic reactions with a prevalence ranging from 2.8% to 16.9% among health professionals. It would be responsible for skin and respiratory allergies increasingly common. It has become a concern for allergists hence the interest in defining allerg...

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“…Sicilia et al [6] reported that the prevalence of titanium allergy in 1500 dental implant patients was about 0.6%, which may induce implant failure by inhibiting implant integration. Although titanium allergy is uncommon, the appearance of significant complications in particularly sensitive patients cannot be disregarded [7].…”

Section: Introductionmentioning

confidence: 99%

Zirconia ceramics in metal-free implant dentistry

Han

Zhao

Shen

2016

Advances in Applied Ceramics

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Because of their outstanding mechanical properties, chemical stability, and biocompatibility, 3-mol % yttria-stabilised tetragonal zirconia polycrystals (3Y-TZP), known as zirconia ceramics in dentistry, are an important choice for various types of prosthesis. In addition to extensive use for crown and bridge construction, considerable interest has been generated for applications in implant dentistry, including full-contour zirconia crowns as supra-constructions, zirconia abutments, and novel zirconia implants. However, their use among dentist and researchers is controversial, especially compared with the well-established implants made of titanium alloys. As a latecomer, the merits and limitations of 3Y-TZP are awaiting careful investigation. Design, manufacturing, and clinical operation guidelines are urgently needed. The aim of this review was to address the present status of the application of zirconia ceramics related to implant dentistry by analysing the published data from both in vitro and in vivo studies. Suggestions are provided for potential improvements and suitable applications of zirconia ceramics in metal-free implant dentistry. ARTICLE HISTORY

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Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients

Abstract: Ti allergy can be detected in dental implant patients, even though its estimated prevalence is low (0.6%). A significantly higher risk of positive allergic reaction was found in patients showing post-op allergy compatible response (ACRG), in which cases allergy tests could be recommended.

Cited by 374 publications

References 54 publications

Initial attachment of human oral keratinocytes cultured on zirconia or titanium

Initial attachment of human oral keratinocytes cultured on zirconia or titanium

Allergènes en chirurgie bucco-dentaire

Zirconia ceramics in metal-free implant dentistry

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