Titanium Alloys as Implant Materials

Imam, M. Ashraf; Fraker, Anna C.

doi:10.1520/stp16066s

Cited by 28 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The stronger the passive film, the higher the corrosion resistance of the implants. The quantities of released metals change depending on the nature and strength of the metaloxide bond, structure, composition and thickness of oxide films [13][14][15]. The oxide film formed on stainless steel or on the Co-Cr-Mo alloy mainly consists of Cr 2 O 3 .…”

Section: Article In Pressmentioning

confidence: 99%

Comparison of metal concentrations in rat tibia tissues with various metallic implants

et al. 2004

View full text Add to dashboard Cite

Section: Article In Pressmentioning

confidence: 99%

Comparison of metal concentrations in rat tibia tissues with various metallic implants

et al. 2004

View full text Add to dashboard Cite

“…2,3 Ti(cpi) is used to fabricate implants used in dentistry 4 and maxillofacial reconstruction, 5 as well as to coat devices constructed from titanium alloy. 6 Although Ti(cpi) is not strong enough to be used in orthopedics, 7 the addition of Al and V to Ti creates an alloy with great strength; and together with its low elastic modulus and excellent biocompatibility, 8 this makes it a preferred orthopedic material.…”

Section: Introductionmentioning

confidence: 99%

Titanium substrata composition influences osteoblastic phenotype:In vitro study

Zreiqat

Howlett

1999

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

In spite of observed differences at the interface between boon and either commercially pure titanium [Ti(cpi)] or titanium alloy (Ti-6Al-4V), the mechanism of such a response is ill understood. This prompted further investigation of the influence of similar metals on human bone-derived cells (HBDCs). This study investigated the influence of Ti(cpi) and its alloy on osteoblastic proteins formed by HBDCs grown for 5, 7, 10, and 14 days on these metals and compared them to cells grown on tissue culture polystyrene plates. Messenger RNA and translated proteins that form an array of osteogenic parameters were determined: alkaline phosphatase (ALP), thrombospondin, osteopontin, osteocalcin (OC), osteonectin (ON/SPARC), type I collagen (Col I) and bone sialoprotein (BSP). At the four predetermined time points, cells grown on either Ti(cpi) or Ti-6Al-4V generally expressed similar mRNA levels, while levels of their respective proteins differed. Cells on Ti(cpi) had peak levels for most proteins at day 7, whereas those on Ti-6Al-4V peaked at either day 5 and/or day 7. At day 5 cells grown on Ti-6Al-4V had higher levels of ALP, Col I, ON/SPARC, OC, and BSP than those in Ti(cpi); this difference was not maintained at later time points in culture. The differential regulation of proteins occurring between cells from the same patient grown on titanium and its alloy implies that HBDCs respond to small differences in the surface chemistry and/or microcrystallinity.

show abstract

“…Commercially pure titanium is used in dentistry and in maxillofacial reconstruction (6). The Ti6Al4V alloy exhibits superior strength and a lower modulus of elasticity that, coupled with its excellent biocompatibility, make it a favoured material for orthopaedic applications (7). The Ti6Al4V alloy has also been successfully utilized in the dental field (8).…”

mentioning

confidence: 99%

Titanium alloy surface oxide modulates the conformation of adsorbed fibronectin to enhance its binding to α₅β₁ integrins in osteoblasts

Rapuano¹,

Lee²,

MacDonald³

2012

European J Oral Sciences

View full text Add to dashboard Cite

Our laboratory has previously demonstrated that heat (600 °C) or radiofrequency plasma glow discharge (RFGD) pretreatment of a titanium alloy (Ti6Al4V) increases the net-negative charge of the alloy’s surface oxide and the attachment of osteoblastic cells to adsorbed fibronectin. The purpose of the current study was to investigate the biological mechanism by which these surface pretreatments enhance the capacity of fibronectin to stimulate osteoblastic cell attachment. Each pretreatment was found to increase the binding (measured by ELISA) of a monoclonal anti-fibronectin Ig to the central integrin-binding domain of adsorbed fibronectin, and to increase the antibody’s inhibition of osteogenic cell attachment (measured using the hexosaminidase assay). Pretreatments also increased the binding (measured by ELISA) of anti-integrin Igs to the α5 and β1 integrin subunits that became attached to fibronectin during cell incubation. These findings suggest that negatively charged surface oxides of Ti6Al4V cause conformational changes in fibronectin that increase the availability of its integrin-binding domain to α5β1 integrins.

show abstract

Titanium Alloys as Implant Materials

Cited by 28 publications

References 0 publications

Comparison of metal concentrations in rat tibia tissues with various metallic implants

Comparison of metal concentrations in rat tibia tissues with various metallic implants

Titanium substrata composition influences osteoblastic phenotype:In vitro study

Titanium alloy surface oxide modulates the conformation of adsorbed fibronectin to enhance its binding to α₅β₁ integrins in osteoblasts

Contact Info

Product

Resources

About

Titanium Alloys as Implant Materials

Cited by 28 publications

References 0 publications

Comparison of metal concentrations in rat tibia tissues with various metallic implants

Comparison of metal concentrations in rat tibia tissues with various metallic implants

Titanium substrata composition influences osteoblastic phenotype:In vitro study

Titanium alloy surface oxide modulates the conformation of adsorbed fibronectin to enhance its binding to α5β1 integrins in osteoblasts

Contact Info

Product

Resources

About

Titanium alloy surface oxide modulates the conformation of adsorbed fibronectin to enhance its binding to α₅β₁ integrins in osteoblasts