Titanium carbide/zeolite imidazole framework-8/polylactic acid electrospun membrane for near-infrared regulated photothermal/photodynamic therapy of drug-resistant bacterial infections

Zhang, Siqi; Ye, Junwei; Liu, Xin; Wang, Ye; Li, Chao; Fang, Jiatong; Chang, Baoning; Qi, Ye; Li, Yachen; Ning, Guiling

doi:10.1016/j.jcis.2021.04.109

Cited by 68 publications

(32 citation statements)

References 72 publications

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“…Coincidentally, this multifunctional platform can provoke the emergence of ROS to accelerate the closure of bacterial invasive wounds, and its bactericidal rates to E. coli and MRSA reached 99.9% and 99.8% respectively. 70 Undeniably, normal skin tissue may also be damaged by a large amount of ROS. A polyvinylpyrrolidone (PVP)-functionalized Nb 2 C nanosheet (Nb 2 C-PVP NSs) was reported in a recent study.…”

Section: Mxene Acts As a Photodynamic Agent For Wound Healingmentioning

confidence: 99%

“…A MZ‐8/PLA electrospun membrane with photothermal and photodynamic properties was reported by Zhang's group. Coincidentally, this multifunctional platform can provoke the emergence of ROS to accelerate the closure of bacterial invasive wounds, and its bactericidal rates to E. coli and MRSA reached 99.9% and 99.8% respectively 70 . Undeniably, normal skin tissue may also be damaged by a large amount of ROS.…”

Section: Applications Of Mxene Nanomaterials In Tissue Engineering An...mentioning

confidence: 99%

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Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Zhong

Huang

Feng

et al. 2022

J Biomedical Materials Res

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MXene, as a new two‐dimensional nanomaterial, is endowed with lots of particular properties, such as large surface area, excellent conductivity, biocompatibility, biodegradability, hydrophilicity, antibacterial activity, and so on. In the past few years, MXene nanomaterials have become a rising star in biomedical fields including biological imaging, tumor diagnosis, biosensor, and tissue engineering. In this review, we sum up the recent applications of MXene nanomaterials in the field of tissue engineering and regeneration. First, we briefly introduced the synthesis and surface modification engineering of MXene. Then we focused on the application and development of MXene and MXene‐based composites in skin, bone, nerve and heart tissue engineering. Uniquely, we also paid attention to some research on MXene with few achievements at present but might become a new trend in tissue engineering and regeneration in the future. Finally, this paper will also discuss several challenges faced by MXene nanomaterials in the clinical application of tissue engineering.

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Section: Mxene Acts As a Photodynamic Agent For Wound Healingmentioning

confidence: 99%

Section: Applications Of Mxene Nanomaterials In Tissue Engineering An...mentioning

confidence: 99%

Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Zhong

Huang

Feng

et al. 2022

J Biomedical Materials Res

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“…The MXene/ZIF‐8 PLA ENMs achieved both photodynamic and photothermal properties under 808 nm laser and the antibacterial rate is up to 99.8% against MRSA (Figure 7C). 114 However, the photosensitizers loaded onto the surfaces of ENMs tend to fall off and show side effects when direct contact with tissues. Curcumin is extracted from organism extracts to act as photosensitizers, through in situ electrospinning prepared core‐shell composite ENMs, and the ENMs could exhibit bactericidal properties at 20 min of 808 nm irradiation and the antibacterial effect reached 95% against MRSA and DR E. coli .…”

Section: Fight Arb With Alternative Weaponsmentioning

confidence: 99%

Section: Fight Arb With Alternative Weaponsmentioning

confidence: 99%

Nanofibrous dressing: Potential alternative for fighting against antibiotic‐resistance wound infections

Yingjie

Zhang

et al. 2022

J of Applied Polymer Sci

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The progression of antibiotic‐resistant bacteria (ARB) as well as impaired immunity due to chronic diseases and complications, aging, and so forth pose opportunities in parallel with challenges to the wound dressing products. In a bid to address the remedies, electrospun nanofibrous membranes (ENMs) with high permeability and good biocompatibility have made an entry as wound dressings. With high specific surface area, such ENMs can pave the way for the loading and release of antimicrobial agents and further promote wound healing by mimicking the extracellular matrix structure. In this review, we have compiled a series of novel antimicrobial agents that can be substituted for antibiotics against ARB and outlined their antimicrobial mechanisms, providing an overview of the latest research to illustrate how ENMs can achieve the loading and efficient release of antimicrobial agents against ARB. Last but not least, on the basis of the demands for timely and accurate wound diagnosis, ENMs capable of colorimetric detection are featured as test‐strips for the diagnosis of wound pathogenic bacteria, in the hope of inspiring researchers to design smart wound dressings capable of diagnosis and treatment integration.

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“…MXene quantum dot (MQD) has attracted much attention due to the localized surface plasma resonance (LSPR) effect [26] and good biocompatibility. According to previous research, MQD is not only a photosensitizer but also a photothermal agent, so it endows a substance to have the PDT/PTT effect at the same time [27]. However, MQD has been discovered to be prone to agglomeration in solution, which can reduce its PDT and PTT effects and lead to poor transportation to the target tumor site for action [28].…”

Section: Introductionmentioning

confidence: 99%

MXene Quantum Dot/Zeolitic Imidazolate Framework Nanocarriers for Dual Stimulus Triggered Tumor Chemo-Phototherapy

Feng

Wang

et al. 2022

Materials

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It is critical to construct stimuli-responsive multifunctional nanoparticles for the drug delivery system for cancer treatment. Zeolitic imidazolate framework-8 (ZIF-8) has a large specific surface area and decomposes quickly under acidic conditions, which presents an excellent potential in pH-sensitive drug carriers. However, the mere chemotherapeutic drug loaded into ZIF-8 is a monotherapy and may restrict the therapeutic efficacy of malignancies. In this work, an effective nanoparticle-based delivery platform is established to simultaneously encapsulate doxorubicin (DOX) and MXene quantum dot (MQD) in ZIF-8 nanoparticles (MQD@ZIF-8/DOX). Under near-infrared (NIR) laser (808 nm) and UV light (365 nm) irradiation, MQD@ZIF-8 demonstrates a high photothermal conversion efficiency and reactive oxygen species (ROS) production, which shows excellent photothermal therapy and photodynamic therapy effects. Furthermore, the release of DOX-loaded into MQD@ZIF-8 nanoparticles is significantly increased under NIR laser irradiation and at pH 5.6, indicating that acidic conditions and NIR laser irradiation can be effectively combined to stimulate the drug release. The cellular experiments show that MQD@ZIF-8/DOX has an obvious killing effect on HeLa cells and achieves the combined anti-tumor effect of chemotherapy and phototherapy.

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Titanium carbide/zeolite imidazole framework-8/polylactic acid electrospun membrane for near-infrared regulated photothermal/photodynamic therapy of drug-resistant bacterial infections

Cited by 68 publications

References 72 publications

Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Nanofibrous dressing: Potential alternative for fighting against antibiotic‐resistance wound infections

MXene Quantum Dot/Zeolitic Imidazolate Framework Nanocarriers for Dual Stimulus Triggered Tumor Chemo-Phototherapy

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