Nanofibrous dressing: Potential alternative for fighting against antibiotic‐resistance wound infections

Abstract

The progression of antibiotic‐resistant bacteria (ARB) as well as impaired immunity due to chronic diseases and complications, aging, and so forth pose opportunities in parallel with challenges to the wound dressing products. In a bid to address the remedies, electrospun nanofibrous membranes (ENMs) with high permeability and good biocompatibility have made an entry as wound dressings. With high specific surface area, such ENMs can pave the way for the loading and release of antimicrobial agents and further promote wound healing by mimicking the extracellular matrix structure. In this review, we have compiled a series of novel antimicrobial agents that can be substituted for antibiotics against ARB and outlined their antimicrobial mechanisms, providing an overview of the latest research to illustrate how ENMs can achieve the loading and efficient release of antimicrobial agents against ARB. Last but not least, on the basis of the demands for timely and accurate wound diagnosis, ENMs capable of colorimetric detection are featured as test‐strips for the diagnosis of wound pathogenic bacteria, in the hope of inspiring researchers to design smart wound dressings capable of diagnosis and treatment integration.

Design of Sponge-like Chitosan Wound Dressing with Immobilized Bacteriophages for Promoting Healing of Bacterially Infected Wounds

“…Various antimicrobial agents, such as antibiotics (e.g. quinolones, tetracyclines, aminoglycosides, cephalosporins), antiseptics (including iodine and chlorhexidine), essential oils, silver and zinc nanoparticles, are incorporated into wound dressings to enhance their bactericidal properties [28, 29,30,31]. The latest trend aimed at combating the increasing crisis of multi-drug resistant bacterial infections is to include bacteriophages in wound dressings as an antimicrobial component [6, 32,33,34].…”

Tannic acid-functionalized 3D porous nanofiber sponge for antibiotic-free wound healing with enhanced hemostasis, antibacterial, and antioxidant properties

“…Bacterial infection will trigger body immune response leading to inflammation, tissue damage, and can be potentially life-threatening [ 13 ]. Hence, an ideal wound dressing should possess efficient antibacterial properties to avoid serious infection.…”

Anchoring Guanidine Polymer onto Sesbania Gum to Endow Excellent Antibacterial Function

“…[1,2] There is no doubt that the antibiotics have succeeded in preventing pathogenic bacteria and global spread of infectious diseases, while the abuse of antibiotics accelerated the growth of bacterial resistance. [3,4] As a DOI: 10.1002/macp.202200430 result, an increasing number of traditional antibiotics are failing. So a variety of antibacterial agents have been explored as an alternative choice for combating pathogens.…”