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Developing an antibiotic-free wound dressing with effective hemostasis and antibacterial and antioxidant capacity is highly desirable. In this work, a three-dimensional (3D) chitosan/polyvinyl alcohol-tannic acid porous nanofiber sponge (3D-TA) was prepared via electrospinning. Compared with two-dimensional (2D) fiber membrane, the unique fluffy 3D-TA nanofiber sponge had high porosity, water absorption and retention ability, hemostatic capacity. Furthermore, the 3D sponge functionalized by tannic acid (TA) endow the sponge with high antibacterial and antioxidant capacity without loading antibiotics. In addition, 3D-TA composite sponges have shown highly biocompatibility against L929 cells. The in vivo experiment shows the 3D-TA is enable to accelerate wound healing. This newly 3D-TA sponges hold great potential as wound dressings for future clinical application.

The fabrication of functional wound dressing for effective hemostasis, anti-inflammation as well as angiogenesis is of vital importance. In this paper, a three-dimensional (3D) nanofiber sponge with dimethyloxaloglycine (DMOG) loaded mesoporous spheres of derivatives of Prussian blue analogues (PBA) was prepared (3D-PBAFeCo-DMOG). The nanostructure, composition, and mechanical properties of 3D-PBAFeCo-DMOG were characterized, showing regular nanostructure and good mechanical property. The behaviour of in vitro drug release showed the DMOG could achieve long-term and stable release by encapsulating in PBAFeCo microspheres and nanofibers. In vitro coagulation experiments showed that 3D-PBAFeCo-DMOG had effective hemostasis and clotting capacities. In addition, the antioxidant capacity and cell compatibility of 3D-PBAFeCo-DMOG were confirmed. These results indicate that 3D-PBAFeCo-DMOG nanofiber sponge, as a controlled drug release system, may provide a new strategy for promoting angiogenesis and wound healing for clinical applications.

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