Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing

Chen, Jiatian; Huang, Zihang; Zhang, Hongqian; Zhang, Zhongyang; Wang, Donghui; Xia, Dan; Yang, Chuanxu; Dong, Mingdong

doi:10.1016/j.cej.2022.136234

Cited by 40 publications

(28 citation statements)

References 41 publications

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“…Staphylococcus aureus (S. aureus)-infected fullthickness wound was well-established on BALB/c male mice to evaluate the efficiency of the 3D-Ag-MOF-CUR sponge on wound healing. 35 On day 3, a significant reduction in the area of a wound treated with modified sponges (3D-Ag-MOF and 3D-Ag-MOF-CUR) was observed, while the wounds of other groups (control, 2D nanofiber, and 3D sponge without active compound) had no obvious signs of healing, which related to the severe inflammatory response. Moreover, the two modified sponge groups found no evident swelling, redness, or suppuration.…”

Section: Nanofibersmentioning

confidence: 92%

“…At first, a 3D layered nanofibrous sponge was created using PCL and GEL, and then 3D‐silver metal–organic frameworks (Ag‐MOF)‐CUR was fabricated after in situ growth of Ag‐MOF and CUR loading in the 3D sponge. Staphylococcus aureus ( S. aureus )‐infected full‐thickness wound was well‐established on BALB /c male mice to evaluate the efficiency of the 3D‐Ag‐MOF‐CUR sponge on wound healing 35 . On day 3, a significant reduction in the area of a wound treated with modified sponges (3D‐Ag‐MOF and 3D‐Ag‐MOF‐CUR) was observed, while the wounds of other groups (control, 2D nanofiber, and 3D sponge without active compound) had no obvious signs of healing, which related to the severe inflammatory response.…”

Section: Nanofibersmentioning

confidence: 99%

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Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

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Despite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.

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Section: Nanofibersmentioning

confidence: 92%

Section: Nanofibersmentioning

confidence: 99%

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

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“…44,45 Thus, effectively inhibiting bacterial growth is essential for wound dressings. 46 Firstly, the agar plate diffusion method tested the antibacterial property of Ag/ Zn@PLA against S. aureus and E. coli. As shown in Fig.…”

Section: Antibacterial Performance Of Ag/zn@plamentioning

confidence: 99%

Electroactive nanofibrous membrane with temperature monitoring for wound healing

Yang

Wang

et al. 2023

RSC Adv.

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“…Curcumin, a biologically active compound, has attracted much attention in the past two decades due to its wide range of biological activities such as antioxidant [1], anti-inflammatory [2], anti-tumourigenic [3], anticoagulant [4], antibacterial [5], anti-carcinogenic [6], anti-ischemic [7] and wound healing [8,9] properties. Despite its potential, curcumin is not widely used in medicine due to its poor aqueous solubility, low gastrointestinal absorption, poor bioavailability, and rapid metabolism [10,11].…”

Section:  Introductionmentioning

confidence: 99%

Impact of active sites on encapsulation of curcumin in Metal Organic Frameworks

Silva

Munasinghe

et al. 2023

Mater. Res. Express

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In this study, we present the investigation of the curcumin loading and release properties of four different Metal-Organic Frameworks (MOFs) with varying metal centres and organic ligands. Through our research, we have identified HKUST-1 and MIL-100, highly porous copper and iron-containing MOFs, that exhibit specific interactions with curcumin, leading to high encapsulation efficiencies (55%-75%) even at low concentrations as 6ppm. The binding modes of curcumin onto MOFs have been investigated using a combined experimental and computational approach. Furthermore, our drug-releasing studies have revealed slow and prolonged release for over two days, which further indicates the specific interactions of curcumin with HKUST-1 and MIL-100. To the best of our knowledge, this is the first comparative study that investigates the drug delivery properties of curcumin using Copper, Ferrous, and Zinc MOFs. Our findings pave the way for the development of stable, highly interactive MOFs as drug carriers for curcumin, which has the potential to overcome its poor aqueous solubility and rapid metabolism, and enhance its pharmacological activities in medicine.

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Three-dimensional layered nanofiber sponge with in situ grown silver- metal organic framework for enhancing wound healing

Cited by 40 publications

References 41 publications

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Electroactive nanofibrous membrane with temperature monitoring for wound healing

Impact of active sites on encapsulation of curcumin in Metal Organic Frameworks

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