Titanium dioxide nanoparticle-induced dysfunction of cardiac hemodynamics is involved in cardiac inflammation in mice

Abstract

In the past two decades, titanium dioxide nanoparticles (TiO NPs) have been extensively used in medicine, food industry and other daily life, while their possible interactions with the their influence and human body on human health remain not well understood. Thus, the study was designed to examine whether long-term exposure to TiO NPs cause myocardial dysfunction which is involved in cardiac lesions and alter expression of genes and proteins involving inflammatory response in the mouse heart. The findings showed that intragastric feeding for nine consecutive months with TiO NPs resulted in titanium accumulation, infiltration of inflammatory cells and apoptosis of heart, reductions in net increases of body weight, cardiac indices of function (LV systolic pressure, maximal rate of pressure increase over time, maximal rate of pressure decrease over time and coronary flow), and increases in heart indices, cardiac indices of function (LV end-diastolic pressure and heart rate) in mice. TiO NPs also decreased ATP production in the hearts. Furthermore, TiO NPs increased expression of nuclear factor-κB, interleukin-lβ and tumour necrosis factor-α, and reduced expression of anti-inflammatory cytokines including suppressor of cytokine signaling (SOCS) 1 and SOCS3 in the cardiac tissue. These results suggest that TiO NPs may modulate the cardiac function and expression of inflammatory cytokines. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2917-2927, 2016.

Effects of titanium dioxide nanoparticles on the myocardium of the adult albino rats and the protective role of β-carotene (histological, immunohistochemical and ultrastructural study)

“…In the current study, there were deeply eosinophilic necrotic muscle fibers with pyknotic nuclei and hemorrhage was present between the cardiomyocytes in the treated group. Similar results were reported by Sheng et al (2013) and Hong et al (2016). In this study, inflammatory infiltration was observed in the myocardium and epicardium of TiO 2 NPs treated group by light microscopic examination and the monocyte cell was detected in the interstitium by electron microscopy.…”

Blood titanium level as a biomarker of orthopaedic implant wear

“…Titanium alloys may also be a source of TiO2 [69]. Exposure to TiO2 nanoparticles was linked to cardiac inflammation [22,70], brain damage [71], impairment of spatial recognition memory [72] and learning abilities [73] in mice. Concerns have also been raised over possible genotoxicity and carcinogenicity of titanium debris [74].…”

Internalization of Titanium Dioxide Nanoparticles Is Cytotoxic for H9c2 Rat Cardiomyoblasts

“…Daily gastrointestinal administration of TiO 2 NPs at 0, 2, 10, 50 mg/kg in rats for up to three months resulted in cardiac dysfunction and inflammatory response [ 7 ]. Intragastric feeding of mice with TiO 2 NPs for nine consecutive months resulted in their accumulation in the heart causing inflammation, apoptosis and cardiac dysfunction [ 8 ].…”