Titanium dioxide particle – induced goblet cell hyperplasia : association with mast cells and IL-13

Abstract

Background: Inhalation of particles aggravates respiratory symptoms including mucus hypersecretion in patients with chronic airway disease and induces goblet cell hyperplasia (GCH) in experimental animal models. However, the underlying mechanisms remain poorly understood.

Pulmonary Exposure to Particles during Pregnancy Causes Increased Neonatal Asthma Susceptibility

“…Moreover, TiO 2 particles were shown to cause pulmonary inflammation with activation of antigen-presenting cells and production of certain chemokines (32,33). They were also associated with increased production of IL-13 by mast cells (34) and, potentially germane to our study, were shown to cause increase IL-25 and IL-13 production by lung antigen-presenting cells (35). Similarly, there are a few studies showing that another generally ''inert'' particle type, CB particles may have also minor immune system effects (36).…”

Simultaneous degradation by corrosion and wear of titanium in artificial saliva containing fluorides

“…There are evidences that the size of debris is more important than their chemical composition, revealing that small particles at nanometer scale are more dangerous than large ones at micrometer scale [22,23,45]. In literature, titanium wear debris has been reported with granular, needle-like, filamentous or plate-like 23 23 morphology and diameter ranging from 0,01 µm up to 50 µm [22,46].…”

Comparative in vitro cytotoxicity study of silver nanoparticle on two mammalian cell lines

“…At these sites, nanoparticles can undergo a series of processes like binding and reacting with proteins, phagocytosis, deposition, clearance and translocation. On the other hand nanoparticles can elicit a spectrum of tissue responses such as cell activation, generation of Reactive Oxygen Species (ROS), inflammation and cell death (Chen et al, 2006;Xia et al, 2006;Ahn et al, 2005).…”