Titanium Element Level in Peri-Implant Mucosa

Mercan, Selda; Yayla, Murat

doi:10.5504/bbeq.2013.0007

Cited by 15 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mercan et al [12] evaluated the presence of titanium in gingival tissues after contact with the cover screws of dental implants for three months using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) technique and reported a higher amount of titanium in the experimental group (50.4 mg/g) compared to the control group (37.1 mg/g). The control group consisted of gingival tissues from subjects, who had no dental implants and had undergone gingivoplasty.…”

Section: Resultsmentioning

confidence: 99%

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Paknejad

Bayani

Yaghobee

et al. 2015

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

Corrosion of implant components, including that of cover screws, has been reported as a possible etiological factor for implant failure. This study evaluated the presence of metallic particles in the soft tissues overlying two-stage implants after placing cover screws, by using a histological technique and energy-dispersive X-ray spectroscopy. The results showed large and small titanium particles in different layers of the soft tissue overlying the implant and cover screws in the majority of samples, with more particles near the cover screws. These particles might have contributed to the various degrees of inflammatory reactions detected in the different layers of the overlying soft tissues. Further studies on the corrosion of implants' metallic components are recommended, so that the implant failure rates could be minimized.

show abstract

Section: Resultsmentioning

confidence: 99%

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Paknejad

Bayani

Yaghobee

et al. 2015

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

show abstract

“…These corrosive products, most of which are comprised of free Ti ions, are typically released from the damaged passivation film of the titanium (8). Previous evidence has shown that excessive Ti ions and nanoparticles can hinder cell growth and division in the tissues surrounding the implants (42). in addition, inflammatory cells or phagocytic cells around the implants, including osteoclasts, macrophage and foreign body giant cells, can be activated following Ti ion exposure.…”

Section: Discussionmentioning

confidence: 99%

Role of MAPK/JNK signaling pathway on the regulation of biological behaviors of MC3T3‑E1 osteoblasts under titanium ion exposure

et al. 2020

View full text Add to dashboard Cite

The oral cavity is a complex environment that is constantly undergoing remodeling. This provides a favorable electrolytic aqueous condition, which causes the corrosion of titanium implants and the release of titanium (Ti) ions. The accumulation of Ti ions in the peri-implant tissues may affect the osteogenesis process. Therefore, the present study aimed to investigate the possible effects of Ti ions on osteoblast physiology and its underlying mechanism, specifically the MaPK/JnK signaling pathway. in the present study, Mc3T3-e1 osteoblasts were cultured the medium containing 10 ppm Ti ions. confocal laser scanning microscopy was used to analyze cell morphology and adhesion. alkaline phosphatase (alP) activity assay and western blotting were performed to evaluate the expression of proteins associated with osteogenesis such as runx2 and osterix. nuclear translocation of JnK, a key factor of the MaPK signaling pathway, was visualized and analyzed using immunofluorescence staining. The results showed that 10 ppm Ti ions exerted negative effects on the biological behaviors of Mc3T3-e1 cells, which exhibited reduced adhesion, alP activity and osteogenic differentiation. it was also found that 10 ppm Ti ions activated the MaPK/JnK signaling pathway by promoting the nuclear translocation of JnK via phosphorylation. in addition, the inhibitory effects of 10 ppm Ti ions on Mc3T3-e1 cells was found to be reversed by the JnK inhibitor SP600125. in conclusion, the preset study suggests that the MaPK/JnK signaling pathway serves a key role in the molecular mechanism underlying the changes in osteoblast behavior following Ti ion exposure. These findings may serve as a valuable reference point for the further in-depth exploration of peri-implant bone loss.

show abstract

“…79 Two studies have focused on the evaluation of the Ti release from cover screws of endosteal implants to adjacent gingival tissues, and both showed this phenomenon. 80,81 Mercan et al 80 reported an almost 1.4-fold elevation in the titanium content in gingiva in comparison with the control group in a relatively short time (3 months). Metallic debris can migrate throughout the different layers of the peri-implant soft tissues, as observed by Paknejad et al 81 Mild and moderate inflammations were observed, respectively, in 65.6% and 33.3% of the samples from the epithelium-connective tissue junction, while mild, moderate This journal is © The Royal Society of Chemistry 2016 and severe inflammatory responses were detected in, respectively, 59.4%, 33.3% and 5.2% of the samples from the connective tissuecover screw surface junction.…”

Section: Dental Implantsmentioning

confidence: 99%

Toxicological aspects of soluble titanium – a review of in vitro and in vivo studies

2016

View full text Add to dashboard Cite

Owing to the widespread use of titanium dioxide (TiO) in various food, household and cosmetic products and in industry, the number of publications concerned with the potential toxic effects and health risks related to this substance in both bulk and nano form is steadily increasing. On the other hand, there is also a third form of titanium, ionic, which is produced by the biodegradation of Ti alloy implants. Thus, the growing population of implant recipients should raise concerns about the impact of soluble Ti on human health. Today, the mechanism of this metal's action on the human body is still not fully understood. This review aims to explore the health risks associated especially with long-term use of titanium implants. The paper provides an analysis of data available from the last 10 years concerning investigations of the adverse effects of Ti ions, including in vitro models of various tissues, in vivo studies of implant corrosion in animals and humans, and potential pathomechanisms of the adverse health impact induced by soluble titanium.

show abstract

Titanium Element Level in Peri-Implant Mucosa

Cited by 15 publications

References 36 publications

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Role of MAPK/JNK signaling pathway on the regulation of biological behaviors of MC3T3‑E1 osteoblasts under titanium ion exposure

Toxicological aspects of soluble titanium – a review of in vitro and in vivo studies

Contact Info

Product

Resources

About