2017
DOI: 10.1111/jcpe.12736
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Titanium implant functionalization with phosphate‐containing polymers may favour in vivo osseointegration

Abstract: Functionalizing titanium implants with inorganic or organic phosphate-containing polymers at 10 wt% concentration may stimulate peri-implant bone formation and implant osseointegration at early healing times.

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Cited by 12 publications
(14 citation statements)
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“…However, those coatings were not functionalized with phosphorous compounds. Taking into account that the presence of organophosphate enhances cellular proliferation [ 24 , 43 ], it could be overcoming the slight cytotoxicity of fluconazole, which explains the absence of cytotoxicity of the fluconazole-loaded coatings observed in this work.…”
Section: Discussionmentioning
confidence: 91%
“…However, those coatings were not functionalized with phosphorous compounds. Taking into account that the presence of organophosphate enhances cellular proliferation [ 24 , 43 ], it could be overcoming the slight cytotoxicity of fluconazole, which explains the absence of cytotoxicity of the fluconazole-loaded coatings observed in this work.…”
Section: Discussionmentioning
confidence: 91%
“…Besides surface coating with bioactive metallic ions, surface functionalization using organic and inorganic biopolymers has also been explored. For example, polyphosphoric acid and phosphorylated pullulan (a polysaccharide) have been demonstrated to facilitate early peri‐implant bone healing and osteointegration after 4 weeks of implantation into a porcine bone defect model 102 . Moreover, using Graphene (2D modification of carbon with special nano‐topography and a characteristic rigid and rough structure) to coat a nanostructured Ti surface promoted osteointegration in a rabbit femur implantation model 103 .…”
Section: Impact Of Surface Properties On Osteogenic Process In Vivomentioning
confidence: 99%
“…Hence, PO 4 3– and Ca 2+ ions combine together with more difficulty, and calcium phosphate formation is partially prevented. This also explains the formation of a phosphorous-rich apatite compound, as evident from chemical composition analyses (Ca/P ∼0.7), and which has been reported to be helpful in promoting in vivo osseointegration. On the other hand, the negatively charged ZnO@GO surface is due to the intrinsic abundance of hydroxyl groups of GO and further promotes absorption of Ca 2+ ions from SBF solution. PO 4 3– are then attracted, and finally calcium phosphate compounds are formed.…”
Section: Resultsmentioning
confidence: 86%