Titanium penetration in human enamel after TiF4 application

Chevitarese, Ana Beatriz Alonso; Chevitarese, Orlando; Chevitarese, Leila; Dutra, Paulo Bechara

doi:10.17796/jcpd.28.3.jn86252876j75053

Cited by 22 publications

(25 citation statements)

References 15 publications

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“…In accordance with previous studies [Clarkson and Wefel, 1979;Chevitarese et al, 2004;Magalhães et al, 2008a], EDS analysis showed that this layer is very rich in titanium. Titanium ions might play an important role for the protective capability of TiF 4 as titanium can bind to enamel surfaces and penetrate into sound or demineralised enamel [Clarkson and Wefel, 1979;Chevitarese et al, 2004].…”

Section: Discussionsupporting

confidence: 92%

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Comparison of the Effects of TiF<sub>4</sub> and NaF Solutions at pH 1.2 and 3.5 on Enamel Erosion in vitro

et al. 2009

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This study aimed to analyse and compare the protective effect of buffered (pH 3.5) and native (pH 1.2) TiF₄ in comparison with NaF solutions on enamel erosion. Bovine samples were pretreated with 1.50% TiF₄ or 2.02% NaF (both 0.48 M F) solutions, each at a pH of 1.2 and 3.5. The control group received no fluoride pretreatment. Twenty samples per group were eroded with HCl (pH 2.6) for 10 × 60 s. Erosion was either investigated by profilometry (n = 10) or by determination of calcium release into the acid (n = 10). Additionally, the elemental surface composition was quantified by X-ray energy-dispersive spectroscopy in fluoridated but not eroded samples (6 samples per group). Scanning electron microscopy was performed prior and after erosion (2 samples per group). Cumulative enamel loss (μm) and calcium release (nmol/mm²) were analysed by repeated-measures ANOVA. The Ti and F surface composition was analysed by one-way ANOVA separately for each element. Only TiF₄ at pH 1.2 reduced enamel surface loss significantly. Calcium release was significantly reduced by TiF₄ and NaF at pH 1.2, but not by the solutions at pH 3.5. Samples pretreated with TiF₄ at pH 1.2 showed a significant increase in Ti, while NaF increased F concentration significantly. Only TiF₄ at pH 1.2 induced the formation of a glaze-like layer, which was still present after erosion. Enamel erosion can be significantly reduced by TiF₄ at pH 1.2 but not at pH 3.5. TiF₄ at pH 1.2 was more effective in protecting against enamel erosion than NaF.

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Section: Discussionsupporting

confidence: 92%

“…Titanium ions might play an important role for the protective capability of TiF 4 as titanium can bind to enamel surfaces and penetrate into sound or demineralised enamel [Clarkson and Wefel, 1979;Chevitarese et al, 2004]. It is assumed that the coating found after the application of TiF 4 is composed of organometallic complexes.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of TiF<sub>4</sub> and NaF Solutions at pH 1.2 and 3.5 on Enamel Erosion in vitro

et al. 2009

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“…But it can be suggested that the titanium ion plays a decisive role. Titanium ions can bind to, and penetrate, sound or decayed enamel surfaces [Chevitarese et al, 2004;Clarkson and Wefel, 1979], but there is no information about the retention of titanium under acidic conditions. We have observed, in agreement with these findings, that high amounts of titanium could be detected directly after fluoridation and nearly half survived repeated erosive demineralization procedures at least in enamel [4.4 8 1.0 wt% directly after fluoridation, 1.9 8 0.9 wt% (p ^ 0.01) after 6, and 1.7 8 1.1 wt% (p ^ 0.01) after 18 demineralization procedures; data not shown].…”

Section: Discussionmentioning

confidence: 99%

Effect of Titanium Tetrafluoride and Sodium Fluoride on Erosion Progression in Enamel and Dentine in vitro

et al. 2007

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Our aim was to investigate the effect of TiF₄ solutions on mineral loss on enamel and dentine in vitro. Samples were fluoridated 1 × 5 min per day with 1.64% w/v TiF₄ or 2.2% w/v NaF solutions, each with a pH of 1.2, and then subjected to a cyclic de- and remineralization procedure for 5 days. Demineralization was performed for 6 × 10 min per day with citric acid (pH 2.3). In controls no fluoridation was performed. Mineral content was determined by longitudinal microradiography. Enamel mineral loss was markedly reduced by both fluoride solutions, but TiF₄ was significantly more effective than NaF: cumulative mineral loss on day 3 was 61.7 ± 15.0 µm in the NaF and 34.2 ± 13.1 µm in the TiF₄ group (p ≤ 0.001) compared with 121.0 ± 27.0 µm in the control group. Dentine mineral loss ceased after both TiF₄ and NaF applications (cumulative mineral loss on day 5 in controls: 61.0 ± 17.0 µm, in the TiF₄ group: 15.4 ± 13.4 µm and in the NaF group: 21.8 ± 11.8 µm). Both TiF₄ and NaF application reduced mineral loss both on enamel and dentine, which could open new possibilities for a symptomatic therapy of erosions.

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“…The titanium ions can bind to enamel surfaces and penetrate into sound or demineralized enamel. 22 The titanium seemed to interact with the enamel surface, thus leading to an increased fluoride uptake by enamel. 21 Alternatively, it is speculated that titanium phosphate compounds are formed 23 or that titanium can substitute calcium in the apatite lattice, 24 leading to higher acid resistance.…”

Section: Discussionmentioning

confidence: 99%

Role of arginine and fluoride in the prevention of eroded enamel: anin vitromodel

et al. 2013

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Background: The aim of this study was to investigate the effect of arginine and fluoride on the reduction of erosive wear. Methods: Bovine enamel blocks were randomly allocated into four groups (n = 20) and exposed to: ESPR group (8% arginine, 1450 ppm sodium monofluorophosphate, calcium carbonate and titanium dioxide); ESen group (1450 ppm sodium monofluorophosphate, 5% potassium citrate); positive control PC group (1500 ppm sodium monofluorophosphate) and negative control NC group (water). The samples were submitted to six alternating cycles of demineralization-remineralization (cola, 10 minutes; artificial saliva, 1 hour, respectively). Before and between cyclic demineralization and remineralization, blocks were treated with slurries of the respective toothpastes or water (1 minute). Erosive tissue loss was analysed by microhardness and profilometry. Data were analysed by ANOVA and Tukey tests for individual comparisons among the groups (p < 0.05). Results: In microhardness, the ESPR (217.46 AE 55.45) group was significantly better than the other treatment groups (PC = 302.76 AE 96.10; ESen = 315.56 AE 74.56; p < 0.001). The ESPR group showed a similar loss to NC group (NC = 210.8 AE 49.98; p = 0.991). The mean erosion depth (+/-SE, lm) was detected between NC (14.37 AE 1.72) and dentifrices tested (ESPR (4.11 AE 1.34), ESen group (7.64 AE 1.61) and PC (8.20 AE 2.19) (p = 0.000). Conclusions: From the results of the present study, the effectiveness of Sensitive Pro Relief in the prevention of erosive surface loss seems to be attributed to the possible effect of the arginine associated with fluoride.

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Titanium penetration in human enamel after TiF4 application

Cited by 22 publications

References 15 publications

Comparison of the Effects of TiF<sub>4</sub> and NaF Solutions at pH 1.2 and 3.5 on Enamel Erosion in vitro

Comparison of the Effects of TiF<sub>4</sub> and NaF Solutions at pH 1.2 and 3.5 on Enamel Erosion in vitro

Effect of Titanium Tetrafluoride and Sodium Fluoride on Erosion Progression in Enamel and Dentine in vitro

Role of arginine and fluoride in the prevention of eroded enamel: anin vitromodel

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