Titrated Oral Misoprostol as a Safe Route for Induction of Labour at Term (A Clinical Trial)

Saleh, Hend S

doi:10.15406/mojwh.2016.03.00058

Cited by 2 publications

(6 citation statements)

References 20 publications

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“…Kahdija et al [35] induced labor in pregnant women with a medical indication for induction and had found a rate of 41% of cesarean sections in a series of 100 pregnant women after induction with 50 µg of oral Misoprostol every 4 hours. However, Saleh HS et al [34] found a rate of 4% of caesarean section following the same protocol in pregnant women with term pregnancy without medical indication for induction of labor which can be in the same limits than our series.…”

Section: Evolution Of Labor and Maternal Prognosissupporting

confidence: 67%

“…During labor, the rate of pathological modification of FHR was 2.9% (2 fetus). This rate is not different from that found by Saleh HS et al [34] which was 2%. 64 (94.1%) newborns had an Apgar ≥ 7 at the first minute versus 4 (5.9%) who had a low Apgar.…”

Section: Perinatal Prognosiscontrasting

confidence: 52%

“…The failure rate was 2.9% (2 patients) in our series. Saleh HS et al [34] had not found a case of failure and this would be linked to the frequency of administration and the total number of doses to be administered which was 5 doses, whereas in our series we set ourselves a total number of 3 to speak of failure. 2 Journal of Biosciences and Medicines (2.9%) patients delivered by caesarean section.…”

Section: Evolution Of Labor and Maternal Prognosismentioning

confidence: 83%

“…57 (83.8%) of patients delivered within 24 hours. Saleh HS et al [34] found a 96% rate of vaginal delivery within 24 hours. The difference from our study would be related to the fact that they administered 50 µg of Misoprostol every 4 hours with a maximum of 5 doses in a row if uterine contractions were not effective.…”

Section: Evolution Of Labor and Maternal Prognosismentioning

confidence: 98%

See 3 more Smart Citations

Labor Induction with Oral Misoprostol in Term Pregnancy: A Clinical Trial

Matega¹,

Maindo²,

Bosenge³

et al. 2021

JBM

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Introduction: Induction of labor has become an increasingly utilized obstetric intervention in developed countries. It contributes to reduce the maternal and perinatal morbidity and mortality. Dinoprostone derivatives are often used under cardiotocography. In poor countries, health structures have neither fetal monitoring, nor means of preserving Dinoprostone derivatives. Misoprostol therefore constitutes an alternative. This study seeks to establish the efficacy and safety of oral Misoprostol and to assess maternal and perinatal prognosis in an area with limited resource. Methods: This is a multi-center clinical trial, conducted in 3 hospitals centers in Kisangani, Tshopo Province/Democratic Republic of Congo from December 1, 2020 to May 31, 2021. Our sample was constituted with 68 pregnant women with term pregnancy. Fifty micrograms of Misoprostol was administered orally. The data were collected prospectively, their encoding was carried out on an Excel sheet 2013 and their analysis carried out using the EPI INFO software. Results: The average age of the pregnant women was 23.17 ± 5.76 years. The average parity was 1.02 ± 1.2. The average body mass index (BMI) was 24.98 ± 2.55 Kg/m 2 . 66 (97.1%) patients had received a maximum of 3 doses of Misoprostol. Out of the 16 parturients who received 3 doses or more, 11 (68.8%) had a BMI ≥ 25. The average duration of labor was 16.03 ± 7.99 hours. 66 (97.1%) pregnant women had delivered vaginally. 57 (83.8%) patients delivered within 24 hours. Out of the 11 patients who delivered after 24 hours, 7 (63.6%) had a BMI ≥ 25. The induction failure rate was 2.9% (2 patients). 2 (2.9%) fetuses had presented pathological modification of fetal heart rate (FHR). 2 (2.9%) patients had undergone cesarean section. Conclusion: Labor

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Section: Evolution Of Labor and Maternal Prognosissupporting

confidence: 67%

Section: Perinatal Prognosiscontrasting

confidence: 52%

Section: Evolution Of Labor and Maternal Prognosismentioning

confidence: 83%

Section: Evolution Of Labor and Maternal Prognosismentioning

confidence: 98%

See 2 more Smart Citations

Labor Induction with Oral Misoprostol in Term Pregnancy: A Clinical Trial

Matega¹,

Maindo²,

Bosenge³

et al. 2021

JBM

View full text Add to dashboard Cite

show abstract

“…There was one perinatal death in a woman, past dates with oligoamnios and IUGR, had a vacuum delivery for non reassuring fetal heart rate but the baby had intrapartum hypoxia and died 20 minutes after birth. Saleh suggests that oral misoprostol in small, repeated doses in the form of titration has more efficacy and safety and associated with a low incidence of uterine hyperstimulation, low caesarean section delivery rate than vaginal misoprostol for induction of labour at term with unripe cervix [13] . Antil has commented that low dose oral misoprostol solution in titrated doses can be used as a safe and effective alternative in induction of labour as it has lower uterine hyperactivity with good neonatal outcome.…”

Section: Discussionmentioning

confidence: 99%

Simplifying induction of labour

Pujar¹,

As²,

Gl³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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Introduction: Labour induction is one of the most common procedure in obstetrics .Oxytocin is one of the time tested drug , but certain disadvantages associated with oxytocin can be countered by using misoprostol as labour inducing agent. Objectives: 1. To know the efficacy of oral Misoprostol solution in inducing labour 2. To calculate the induction delivery interval 3.To know the maternal and fetal outcome in the study population. Methodology: A prospective observational hospital based study involving 200 term pregnant patients getting admitted to the labour ward. All of them were induced with oral misoprostol in solution form at a static dose regimen, second hourly (20 ug) for a total of five doses. Labour monitored as per the labour room protocol, reassessed after five doses or earlier as per clinical progress. Results: 200 patients were included, the efficacy of its use was excellent, mean number of doses required was 5, with the average induction delivery interval of 13.65 hrs, with 77.5% of vaginal delivery rate and 22.5% of caesarean rate, 30% needed oxytocin augmentation and 6.5% of the babies had meconium staining of liquor, of them 23.08% showed signs of meconium aspiration syndrome and one perinatal death was noted in the study. Conclusion:Oral misoprostol solution in static dosage is a simple, safe and effective method for induction of labour at term.

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Titrated Oral Misoprostol as a Safe Route for Induction of Labour at Term (A Clinical Trial)

Abstract: Objective: To assess safety and efficacy of induction of labour at term by low doses of oral misoprostol in the form of titration versus the standard regimen of vaginal misoprostol in the term of induction delivery interval, operative interventions and fetal outcome.

Cited by 2 publications

References 20 publications

Labor Induction with Oral Misoprostol in Term Pregnancy: A Clinical Trial

Labor Induction with Oral Misoprostol in Term Pregnancy: A Clinical Trial

Simplifying induction of labour

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