TLR-Mediated Production of Reactive Oxygen Species and Tumor Necrosis Factor Alpha by Human Peripheral Blood Neutrophils

Teselkin, Yu. O.; Хорева, М. В.; Veselova, A V; Babenkova, I. V.; Осипов, А. Н.; Gankovskaya, L. V.; Vladimirov, Yu. A.

doi:10.1134/s0006350918020227

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Additionally, the upregulation of TLR1-10, NF-κB and p53 expression is observed in oral lichenoid disease, an auto-immune disease associated with chronic inflammation and malignant potential owing to atypical lichenoid lesions in cases of greater chronic inflammatory response [169,170]. The downstream generation of ROS and activation of NF-κB can indeed amplify the innate immune response, but may also act to generate abnormal patterns of inflammation, which, when chronically activated, prove to be pro-tumorigenic, as previously discussed [171,172]. This has a profound implication on genotoxic and TLR agonist strategies for targeting tumours, whereby enhancing TLR-signalling may instead foster a highly inflammatory yet immunosuppressive TME.…”

Section: P53 Mediates the Genotoxic Stress Response Of The Toll-like Receptor Pathwaymentioning

confidence: 99%

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Agupitan

Neeson

Williams

et al. 2020

IJMS

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Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic drivers on the immune response, as well as their value as targets for immunotherapy. At the heart of tumour suppression is p53, which was discovered in the context of viral infection and now emerges as a significant player in normal and cancer immunity. Wild-type p53 (wt p53) plays fundamental roles in cancer immunity and inflammation. Mutations in p53 not only cripple wt p53 immune functions but also sinisterly subvert the immune function through its neomorphic gain-of-functions (GOFs). The prevalence of mutant p53 across different types of human cancers, which are associated with inflammatory and immune dysfunction, further implicates mutant p53 in modulating cancer immunity, thereby promoting tumorigenesis, metastasis and invasion. In this review, we discuss several mutant p53 immune GOFs in the context of the established roles of wt p53 in regulating and responding to tumour-associated inflammation, and regulating innate and adaptive immunity. We discuss the capacity of mutant p53 to alter the tumour milieu to support immune dysfunction, modulate toll-like receptor (TLR) signalling pathways to disrupt innate immunity and subvert cell-mediated immunity in favour of immune privilege and survival. Furthermore, we expose the potential and challenges associated with mutant p53 as a cancer immunotherapy target and underscore existing therapies that may benefit from inquiry into cancer p53 status.

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Section: P53 Mediates the Genotoxic Stress Response Of The Toll-like Receptor Pathwaymentioning

confidence: 99%

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Agupitan

Neeson

Williams

et al. 2020

IJMS

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“…NF-κB) activation, cytokine production, and finally macrophage stimulation. 5,44,45 Endogenous HOCl burst is expected during an LPS challenged inflammatory cascade in living mice. In this study, mice in experimental group were given an intraperitoneal (i.p.)…”

Section: Recurring In Vivo Imaging Of Endogenous Hocl In Stimulated Micementioning

confidence: 99%

Recurring Real-Time Monitoring of Inflammations in Living Mice with a Chemiluminescent Probe for Hypochlorous Acid

Yang

et al. 2022

CCS Chem

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Probes for in vivo imaging of hypochlorous acid (HOCl), one of the most important reactive oxygen species in innate immunity, are urgently needed to understand pathogenesis of auto-immune and neuro-inflammatory disorders. As a strong oxidant, HOCl could easily bleach near-infrared sensors and inactivate luciferase, making in vivo imaging overwhelmingly challenging. By fine-tuning a selective HOCl sensing moiety, HOCl stable spacer and bright chemiluminescent scaffold, we have developed HOCl-CL-510 as a highly selective and sensitive probe for HOCl detection both in vitro and in vivo. In particular, recurring real-time monitoring of HOCl was achieved in both acute and chronic inflammation models in living mice, providing a new chemical tool for dynamic monitoring of disease development with reduced usage of experimental animals.

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TLR-Mediated Production of Reactive Oxygen Species and Tumor Necrosis Factor Alpha by Human Peripheral Blood Neutrophils

Cited by 2 publications

References 25 publications

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Recurring Real-Time Monitoring of Inflammations in Living Mice with a Chemiluminescent Probe for Hypochlorous Acid

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