TLR4 rs1927911, but Not TLR2 rs5743708, Is Associated With Atherosclerotic Cerebral Infarction in the Southern Han Population

Abstract

The objective of this study was to explore the association of toll-like receptor (TLR) 4 rs1927911 and TLR2 rs5743708 with atherosclerotic cerebral infarction (ACI) and their effects on blood pressure, fasting blood glucose, and blood lipids in the Han population of Hunan Province.TLR4 rs1927911 and TLR2 rs5743708 were detected by polymerase chain reaction and restriction fragment length polymorphism in 170 patients with ACI and 149 healthy controls.Our results indicated that the genotype and allele frequencies of TLR4 rs1927911 were significantly different between ACI patients and controls, whereas those of TLR2 rs5743708 were not significantly different between the 2 groups. For TLR4 rs1927911, blood pressure, fasting blood sugar, and serum lipid levels were not significantly different among different genotypes in the ACI and control groups.The rs1927911 polymorphism of the TLR4 gene may be a risk factor for ACI in the Southern Han population of Hunan Province; however, it may not be associated with blood pressure, fasting blood sugar, or blood lipids.

TLR4 polymorphisms may increase susceptibility to periodontitis in Pg-positive individuals

“…Rs1927911 had been reported to be associated with T2DM in southern Chinese (Peng et al, 2015). The rs1927911 polymorphism of the TLR4 gene may be a risk factor for atherosclerotic cerebral infarction (ACI) in the Southern Han population of Hunan Province (Song et al, 2015). However, it may not be associated with fasting blood sugar (Song et al, 2015).…”

“…The rs1927911 polymorphism of the TLR4 gene may be a risk factor for atherosclerotic cerebral infarction (ACI) in the Southern Han population of Hunan Province (Song et al, 2015). However, it may not be associated with fasting blood sugar (Song et al, 2015). Also, there was no direct relation between rs1927911 and diabetes among the Germans (Kolz et al, 2008).…”

Genetic Variants of Toll Like Receptor-4 in Patients with Premature Coronary Artery Disease, South of Iran

“…Results of a study conducted by Yanmin Song et al in the southern Chinese province of Hunan in 2014 showed that for rs1927911 there is a meaningful difference between acute cardiac ischemia (ACI) patients and the control groups from a genotype and allele distribution but hypertension, fasting blood sugar and serum fat level with different genotypes in both ACI patients and control groups had no meaningful difference (20).…”