TNF-238A is associated with juvenile onset psoriasis in patients of Han population in Southwest China

Long, Fu‐Quan; Sun, Chang; Deng, Di; Zhou, Xinlin; Li, Xueping; Zhang, Yaping

doi:10.1016/j.jdermsci.2004.08.004

Cited by 17 publications

(18 citation statements)

References 7 publications

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“…Our observation that carriage of the polymorphism variant TNFα–308A is significantly less common among patients with early‐onset psoriasis than among healthy controls is in agreement with the reports of Mŏssner et al. 6 and Craven et al., 7 and differs from other studies that have failed to find a specific association of psoriasis vulgaris with TNF‐α–308G/A 5,8,9 …”

Section: Discussionsupporting

confidence: 92%

Associations of promoter region polymorphisms in the tumour necrosis factor-? gene and early-onset psoriasis vulgaris in a northern Polish population

Nedoszytko¹,

Szczerkowska-Dobosz²,

Zabłotna³

et al. 2007

Br J Dermatol

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Section: Discussionsupporting

confidence: 92%

Associations of promoter region polymorphisms in the tumour necrosis factor-? gene and early-onset psoriasis vulgaris in a northern Polish population

Nedoszytko¹,

Szczerkowska-Dobosz²,

Zabłotna³

et al. 2007

Br J Dermatol

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“…These studies were published between 1999 and 2012, and most study designs were hospital-based case-control studies [11-20,27-33]. For TNF-α 308 G/A polymorphism, there were a total of 12 studies from Caucasian population [11-13,15,17,18,20,27-29,31,32], 3 studies from Asian population [16,19,30], and only one study from the other populations [14]. For TNF-α 238 G/A polymorphism, there were a total of 10 studies from Caucasian population [11–13,15,18,28,29,31–33], 3 studies from Asian population [16,19,30], and only one study from the other populations [14].…”

Section: Resultsmentioning

confidence: 99%

“…For TNF-α 308 G/A polymorphism, there were a total of 12 studies from Caucasian population [11-13,15,17,18,20,27-29,31,32], 3 studies from Asian population [16,19,30], and only one study from the other populations [14]. For TNF-α 238 G/A polymorphism, there were a total of 10 studies from Caucasian population [11–13,15,18,28,29,31–33], 3 studies from Asian population [16,19,30], and only one study from the other populations [14]. The cases in 13 studies were selected from patients with psoriasis [11-14,16-20,27,30,31,33], while the other 4 studies were from patients with psoriatic arthritis [15,28,29,32].…”

Section: Resultsmentioning

confidence: 99%

“…For TNF-α 238 G/A polymorphism, there were a total of 10 studies from Caucasian population [11–13,15,18,28,29,31–33], 3 studies from Asian population [16,19,30], and only one study from the other populations [14]. The cases in 13 studies were selected from patients with psoriasis [11-14,16-20,27,30,31,33], while the other 4 studies were from patients with psoriatic arthritis [15,28,29,32]. All 17 publications were published in English, and the most common method for testing genotype frequencies of TNF-α polymorphisms was polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).…”

Section: Resultsmentioning

confidence: 99%

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Associations between Tumor Necrosis Factor-α Polymorphisms and Risk of Psoriasis: A Meta-Analysis

Liu

Cai

et al. 2013

PLoS ONE

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BackgroundTumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk. MethodsWe performed a meta-analysis to evaluate the associations between TNF-α polymorphisms and psoriasis. Electronic searches of Pubmed, Embase, and Web of Science were performed for all publications on the associations between TNF-α polymorphisms and psoriasis through September 26, 2012. The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the associations.ResultsSixteen case-control studies with a total of 2,253 psoriasis cases and 1,947 controls on TNF-α 308 G/A polymorphism and fourteen studies on TNF-α 238 G/A polymorphism with 2,104 cases and 1,838 controls were finally included into the meta-analysis. Overall, TNF-α 308 G/A polymorphism was significantly associated with decreased risk of psoriasis under three genetic comparison models (for A versus G: fixed-effects OR 0.71, 95%CI 0.62-0.82, P < 0.001; for AG versus GG: fixed-effects OR 0.67, 95%CI 0.57-0.78, P < 0.001; for AA/AG versus GG: fixed-effects OR 0.67, 95%CI 0.58-0.78, P < 0.001). In addition, TNF-α 238 G/A polymorphism was associated with increased risk of psoriasis under three genetic models (for A versus G: fixed-effects OR 2.46, 95%CI 2.04-2.96, P < 0.001; for AG versus GG: fixed-effects OR 2.69, 95%CI 2.20-3.28, P < 0.001; for AA/AG versus GG: fixed-effects OR 2.68, 95%CI 2.20-3.26, P < 0.001). Subgroup analysis by ethnicity identified a significant association between TNF-α 308 G/A polymorphism and decreased risk of psoriasis in both Caucasians and Asians and a significant association between TNF-α 238 G/A polymorphism and increased risk of psoriasis in Caucasians.ConclusionsThe meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with decreased risk of psoriasis, while TNF-α 238 G/A is associated with increased risk of psoriasis.

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“…Genetic factors may play a significant role in the risk of psoriasis in Chinese [10, 16]. Recent genetic studies indicate that the location of these genes varies considerably among populations and families.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China

2014

International Journal of Genomics

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Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors. The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis. In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age- and sex-matched control subjects were enrolled. Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects. We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs: IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups. Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population. The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27–0.96) in Chinese. Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R. Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population.

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TNF-238A is associated with juvenile onset psoriasis in patients of Han population in Southwest China

Cited by 17 publications

References 7 publications

Associations of promoter region polymorphisms in the tumour necrosis factor-? gene and early-onset psoriasis vulgaris in a northern Polish population

Associations of promoter region polymorphisms in the tumour necrosis factor-? gene and early-onset psoriasis vulgaris in a northern Polish population

Associations between Tumor Necrosis Factor-α Polymorphisms and Risk of Psoriasis: A Meta-Analysis

Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China

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