TNF-α -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China

Li, Zhen; Shuan, LI; Ya, Sun; Liu, Yu; Li, Wenliang; Yang, Li; Duan, Yong; Li, Jingyu; Guo, Hao; Zou, Tianning; Li, Yunlong; Wang, Kunhua

doi:10.1371/journal.pone.0178218

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…The frequency of heterozygous mutation (GA) and secondary allele (A) is significantly higher in gastric cancer patients than in healthy control group ( 16 , 17 ). TNF-α-308 allele polymorphism is associated with body mass index (BMI) and distant metastasis of colorectal cancer patients, and A allele can increase the risk of distant metastasis of colorectal cancer ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer

Liu

et al. 2018

Oncol Lett

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Tumor necrosis factor-α (TNF-α) is closely related to the occurrence of human cancers. Cervical cancer seriously affects female health. Therefore, our study aimed to investigate the correlation between the polymorphism of TNF-α-308 gene and susceptibility to cervical cancer. Whole blood was collected from 142 patients with cervical cancer and 150 healthy controls. PCR-RFLP was used to detect the polymorphism of TNF-α-308 and the correlation between polymorphism of TNF-α-308 and the susceptibility to cervical cancer was analyzed. The three genotypes of TNF-α-308 were GG, GA and AA, and the distributions of genotypes of TNF-α-308 were consistent with Hardy-Weinberg equilibrium in both cervical cancer group and control group. There were no significant differences in genotype and allele frequency between cervical cancer group and healthy control group (P>0.05). A/A genotype increased the risk of cervical cancer by 1.46 times with 95% confidence interval of 0.32–6.67. Different genotypes were not associated with tumor type (P>0.05). Different genotypes are correlated with cervical cancer TNM stages, tumor differentiation and lymph node metastasis. Proportion of GA+AA genotype in TNM stage III+IV group, low differentiation group and lymph node metastasis group were 28.1, 29.0 and 29.8%, respectively, which were significantly higher than those in stage I+II group, moderate/high differentiation group and non-lymph node metastasis group (P<0.05). The results suggested that TNF-α-308 gene polymorphism is associated with the degree of malignancy of cervical cancer. Female patients with A allele have higher malignant degree of cervical cancer.

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Section: Discussionmentioning

confidence: 99%

The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer

Liu

et al. 2018

Oncol Lett

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“…Li i wsp. wskazują na wzrost ryzyka formowania przerzutów odległych u pacjentów z rakiem odbytnicy posiadających mutację w genie kodującym cytokinę TNF-α -308 (substytucja G > A) [82]. W metaanalizie Miao i wsp.…”

Section: Tnf-αunclassified

Impact of selected pro-inflammatory cytokines and oxidative stress on carcinogenesis and progression of prostate and colorectal adenocarcinomas

Fryczkowski¹,

Hejmo

Bułdak

et al. 2019

Ann. Acad. Med. Siles.

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Nowotwory jelita grubego i prostaty są jednymi z najczęściej występujących nowotworów w Polsce, a zapadalność na nie stale rośnie. Przewlekły stan zapalny i stres oksydacyjny są znanymi czynnikami promującymi rozwój nowotworów. Cytokiny prozapalne, takie jak IL-1β, IL-6, IL-8 oraz TNF-α, są wytwarzane w prawidłowych komórkach i odpowiadają za kontrolę kluczowych procesów. Związana z występowaniem przewlekłego stanu zapalnego nadprodukcja może jednak indukować transformację nowotworową, a następnie wspomagać rozwój nowotworu przez ekspresję cytokin przez komórki mikrośrodowiska guza. Stężenie cytokin prozapalnych w surowicy krwi oraz ekspresja w tkance guza mogą być czynnikami diagnostycznymi i prognostycznymi u pacjentów chorych na raka jelita grubego lub prostaty, a terapia antycytokinowa może wydłużyć czas ich przeżycia.

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Inherited variant in NFκB‐1 promoter is associated with increased risk of IBD in an Algerian population and modulates SOX9 binding

Hamadou¹,

Garritano

Romanel

et al. 2020

Cancer Reports

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BackgroundThe link between inflammation and cancer development was intensively studied in the last decade. To date, few studies explored the association between inflammatory genes and colorectal cancer (CRC) development.AimThe present study aimed to evaluate the implication of three single nucleotide polymorphisms (SNPs), rs28362491 ins/del −94 ATTG in NFκB1, rs6920220 (G/A) in TNFAIP3, and rs419598 (C/T) in IL1RN, which play a role in inflammation regulation in CRC development.Methods and resultsA case‐control study was conducted on an Algerian cohort of 358 subjects (147 healthy people, 89 individuals affected by inflammatory bowel disease [IBD], and 122 CRC patients enrolled at the University Hospital Center Ben Badis of Constantine). SNPs genotyping was performed by allelic discrimination TaqMan assay. The rs28362491 ins/del heterozygous genotype in NFκB1 conferred an increased risk of IBD compared with ins/ins homozygous genotype, with an increase of twofold (OR = 2.34 [1.29‐4.21]; 95% CI, 1.29‐4.21, P value = 0.004). No significant association was detected for the other two variants. Dual‐Luciferase Reporter Assay System performed in LoVo cells showed a significantly higher activity of the construct with ins allele of rs28362491 compared with the one harboring the del allele. Computational analysis nominated SOX9 as putative transcription factor (TF) with higher probability to bind the NFκB1 promoter at the SNP site, and we demonstrated in the in vitro assay that its overexpression modulates NFκB1 promoter activity in allele‐specific manner.ConclusionWe speculate that SOX9 may modulate the NFκB1 activity by binding its promoter at the SNP site in allelic specific manner.

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TNF-α -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China

Cited by 5 publications

References 37 publications

The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer

The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer

Impact of selected pro-inflammatory cytokines and oxidative stress on carcinogenesis and progression of prostate and colorectal adenocarcinomas

Inherited variant in NFκB‐1 promoter is associated with increased risk of IBD in an Algerian population and modulates SOX9 binding

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