TNF-α IN THE DEVELOPMENT OF INSULIN RESISTANCE AND OTHER DISORDERS IN METABOLIC SYNDROME

Gwozdziewiczová, Simona; Lichnovská, Radka; Yahia, Rabha Ben; Chlup, Rudolf; Hřebíček, Jiří

doi:10.5507/bp.2005.013

Cited by 30 publications

(28 citation statements)

References 31 publications

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“…In this study, the serum concentration of TNF-a, an inflammatory cytokine implicated in IR, was analyzed in individuals diagnosed with or without MS. A significantly increased concentration of TNF-a was found in the MS group, similar to a previously reported study (15). Indeed, several reports indicate that certain dyslipidemias exhibit pro-inflammatory stages that are associated with elevated TNF-a levels (16)(17)(18)(19).…”

Section: Discussionsupporting

confidence: 90%

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Establishment of a cut‐point value of serum TNF‐α levels in the metabolic syndrome

Gurrola-Díaz

Sánchez‐Enríquez

García-López

et al. 2009

Clinical Laboratory Analysis

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Cardiovascular diseases and type 2 diabetes are the major causes of mortality in Mexico. Metabolic syndrome (MS) is a cluster of factors that increase the risk to develop such diseases. Previous studies have shown that MS is associated with high tumor necrosis factor (TNF-a) levels. In fact, TNF-a has been proposed to be a useful marker for clinical diagnosis of inflammation at an early stage. Therefore, we analyzed TNF-a concentrations in Mexican individuals with or without MS and related these levels to the associated MS components. Clinical, anthropometric, and biochemical data were analyzed in 41 healthy and 39 MS individuals. Individuals were similarly grouped by age and gender.The serum TNF-a levels measured by a highly sensitive enzyme-linked immunosorbent assay (ELISA) kit were increased significantly in MS subjects compared with healthy individuals (Po0.001). The assay showed 78.1% sensitivity and 61.5% specificity with a cut-point level of 1.36 pg/mL. TNF-a levels higher than the cut-point value were correlated with insulin resistance indices. These findings support the hypothesis that serum TNF-a concentration could be a useful marker for early MS diagnosis. Nevertheless, we suggest the establishment of specific cut-point values in each studied population to evaluate potential clinical applications.

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Section: Discussionsupporting

confidence: 90%

“…Interestingly, we found that women with MS had significantly higher TNF-a levels compared with the control women, as described previously; however, TNF-a levels did not vary significantly between MS and control men (15). This finding suggests that TNF-a plays an important role in the development of IR in women.…”

Section: Discussionsupporting

confidence: 87%

Establishment of a cut‐point value of serum TNF‐α levels in the metabolic syndrome

Gurrola-Díaz

Sánchez‐Enríquez

García-López

et al. 2009

Clinical Laboratory Analysis

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show abstract

“…Researches have demonstrated that TNF-α could inhibit exogenous lipid intake and promote fat decomposition simultaneously through inhibiting the activity of lipoprotein lipase in adipocytes, and in this way, TNF-α elevated plasma level of FFA. Blocking TNF-α effect not only increased insulin sensitivity and promoted insulin receptor tyrosine kinase activity but also reduced the plasma FFA level In Zucker rats [13,17], while, in human, TNF-α infusion could increase the level of plasma FFA. All these suggest that exercise ameliorated IR by down-regulating serum TNF-α level and reducing plasma FFA and relieving the lipid deposition [18].…”

Section: Discussionmentioning

confidence: 93%

“…Multiple cytokines, including TNF-α, are involved in the development of IR in the adipose tissue [13,14]. Exercise is proven an important therapeutic method to improve IR in both human and animals [15,16].…”

Section: Discussionmentioning

confidence: 99%

Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

et al. 2009

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This study investigated the effect of exercise training on insulin resistance and serum and adipose TNF-α in high-fat diet-induced insulin-resistant rats. Thirty male Wistar rats were randomly divided into two groups: normal control group (NC; n = 8) that accepted normal chow and high-fat diet group (HF; n = 22) that fed on high-fat diet to induce insulin resistance model. The HF group was randomly assigned to two subgroups after 18 weeks: sedentary group (SE; n = 10) and exercise training group (ET; n = 12) that performed swimming exercise training for 6 weeks, while both groups continued high-fat diet. Changes of body weight, lipid profile, and fasting plasma glucose and insulin were measured. The insulin sensitivity index (ISI) was calculated. Serum concentration of TNF-α was detected by ELISA. The expression of TNF-α mRNA and protein in adipose tissue was examined by using realtime fluorescence quantitative polymerase chain reaction (PCR) and Western blot, respectively. After 18 weeks, compared with the NC group, body weight, blood lipid, glucose, and insulin in the HF group were significantly elevated, while the ISI decreased obviously, which suggested that insulin resistance appeared in the HF group. After exercise training for 6 weeks, compared with the SE group, both ISI and serum TNF-α concentration in the ET group were decreased significantly; however, the expression levels of TNF-α mRNA and protein in adipose tissue increased by 27.5% and 20.5%, respectively. In conclusion, exercise training ameliorates insulin resistance. The reduction of the level of serum TNF-α and the increased expression of TNF-α in adipose tissue by exercise training may be involved in this mechanism.

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“…As insulin resistance develops, serum leptin increases significantly and the serum concentration of leptin receptors drops 9 . With the development of insulin resistance, the role of TNFα is observed, with the concentration rising in obese individuals with an increase in BMI 10 . These metabolic changes signalize negative clinical consequences.…”

Section: Discussionmentioning

confidence: 99%

Potential Markers of Insulin Resistance in Healthy vs Obese and Overweight Subjects

Horáková

Stejskal²,

Pastucha³

et al. 2010

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Insulin resistance can lead to the metabolic syndrome, which may have cardiovascular and metabolic consequences. The study aimed at verifying the serum concentration levels of the adipose tissue proteins adiponectin, adipocyte-fatty acid binding protein (a-FABP) and acylation stimulating protein (ASP), and the potential use of these markers for early diagnosis of insulin resistance.Methods and results. Healthy subjects (Group A, n = 53), overweight subjects (Group B, n = 29) and obese subjects (Group C, n = 51) were studied. Those in Groups B and C had symptoms of insulin resistance. The subjects were selected based on clinical and laboratory findings. The concentrations of adiponectin were highest in the healthy subjects in Group A (14.18 ± 6.99 mg/), lower in the overweight subjects in Group B (11.12 ± 4.46 mg/l) and lowest in the obese subjects in Group C (8.15 ±2.70 mg/l). The a-FABP values were lowest in Group A (20.23 ± 7.95 mg/l), higher in Group B (32.22 ± 15.56 mg/l) and highest in Group C (40.43 ± 23.31 mg/l). The concentrations of ASP were lowest in the Group A healthy subjects (43.01 ± 22.78 nmol/l), higher in the Group B overweight subjects (50.58 ± 25.57 nmol/l) and highest in the Group C obese subjects (54.70 ± 26.41 nmol/l). Statistically significant correlation coefficients in subjects from all groups among the markers studied describe the highest correlation is between a-FABP and BMI (r = 0.48), adiponectin and QUICKI (r = 0.42), adiponectin and triacylglycerols (r = -0.35), ASP and BMI (r = 0.33) and adiponectin and BMI (r = -0.31).Conclusions. The concentrations of all studied markers were different in the healthy subjects as compared to the overweight or obese ones. Adiponectin proved to be a good indicator of insulin sensitivity, the low concentration of which could signal the initial stage of insulin resistance. A-FABP proved to be a prominent marker of "adiposity" in association with the development of insulin resistance. ASP did not prove to show significant differences between the overweight and healthy subjects, but significant differences were found between the obese and healthy subject.

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TNF-α IN THE DEVELOPMENT OF INSULIN RESISTANCE AND OTHER DISORDERS IN METABOLIC SYNDROME

Cited by 30 publications

References 31 publications

Establishment of a cut‐point value of serum TNF‐α levels in the metabolic syndrome

Establishment of a cut‐point value of serum TNF‐α levels in the metabolic syndrome

Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Potential Markers of Insulin Resistance in Healthy vs Obese and Overweight Subjects

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