TNF-α modulates the migratory response of mesenchymal stem cells to TRAIL

Corallini, Federica; Secchiero, Paola; Beltrami, Antonio Paolo; Cesselli, Daniela; Puppato, Elisa; Ferrari, Roberto; Beltrami, Carlo Alberto; Zauli, Giorgio

doi:10.1007/s00018-009-0246-5

Cited by 20 publications

(25 citation statements)

References 44 publications

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“…Our group has recently shown that TRAIL is able to promote the migration of BM-MSC in vitro [26]. OPG dose dependently neutralizes the promigratory activity of TRAIL [27], so the high levels of OPG observed in diabetic patients might impair the pro-migratory signalling driven by TRAIL, accounting for the abnormalities of BM-SC in DM. …”

Section: Rationale For the Use Of Adult Stem/progenitor Cells For mentioning

confidence: 99%

Cell-Based Therapies for Diabetic Complications

Bernardi

Severini

Zauli

et al. 2012

Experimental Diabetes Research

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In recent years, accumulating experimental evidence supports the notion that diabetic patients may greatly benefit from cell-based therapies, which include the use of adult stem and/or progenitor cells. In particular, mesenchymal stem cells and the circulating pool of endothelial progenitor cells have so far been the most studied populations of cells proposed for the treatment of vascular complications affecting diabetic patients. We review the evidence supporting their use in this setting, the therapeutic benefits that these cells have shown so far as well as the challenges that cell-based therapies in diabetic complications put out.

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Section: Rationale For the Use Of Adult Stem/progenitor Cells For mentioning

confidence: 99%

Cell-Based Therapies for Diabetic Complications

Bernardi

Severini

Zauli

et al. 2012

Experimental Diabetes Research

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“…They are considered to reside in specific areas of each tissue and remain inactive for long periods of time, until they are activated by signals indicating that more cells are required to maintain tissue integrity, or by signals from sites of tissue injury. Different cytokines and growth factors are recruited in stem cell fate regulation, including quiescence, self-renewal, differentiation, apoptosis and mobilization from their original niche (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Characteristics of stem cells derived from rat fascia: In vitro proliferative and multilineage potential assessment

Wong

Siu

Fung

et al. 2014

Molecular Medicine Reports

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Fascia‑derived stem cells (FDSCs) were previously isolated from the fascia of the gluteus maximus of the rat. However, the use of FDSCs as a cell source for musculoskeletal tissue engineering has not been compared with that of adipose‑derived stem cells (ADSCs) and bone marrow‑derived mesenchymal stem cells (BMSCs). Therefore, the present study aimed to compare the mesenchymal stem cell (MSC) and self‑renewal stem cell markers, proliferative capacity and multilineage differentiation potential of these stem cells in vitro. The MSC and embryonic stem cell (ESC) marker profiles were compared using flow cytometry and quantitative polymerase chain reaction (qPCR). Their proliferative capacities were compared using 5‑bromo‑2'‑deoxyuridine and MTT assays. Their osteogenic, adipogenic and chondrogenic differentiation potentials were compared using standard staining assays and qPCR. The FDSCs possessed similar cell morphology and immunophenotypic profiles with BMSCs and ADSCs. FDSCs demonstrated a similar expression pattern of ESC markers with ADSCs, which has higher expression of sex determining region Y‑box (Sox)2 and octamer‑binding transcription factor 4, and lower expression of Krüppel‑like factor 4, when compared with BMSCs. FDSCs exhibited higher proliferation under serum‑deprived conditions (0.5% FBS growth medium), and attained higher expression levels of collagen type I, α 2 and type II, α 1 as well as Sox9 mRNA than ADSCs and BMSCs upon chondrogenic induction. An increased amount of proteoglycan deposition was also observed in the FDSC group. However, lower levels of adipogenic and osteogenic marker expression in FDSCs were detected compared with ADSCs and BMSCs upon adipogenic and osteogenic induction, respectively. FDSCs possessed high chondrogenic potential, low osteogenic and adipogenic differentiation potential and were responsive to the induction signals for collagen‑rich fascial structure regeneration. Therefore, FDSCs may represent an improved alternative cell source to conventional ADSCs and BMSCs for musculoskeletal tissue repair and tissue engineering, particularly for collagen‑rich structures with poor vasculature.

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“…TNFα might synergize with IFN‐γ in regulating gene expression in MSCs [Xu et al, 2009]. TRAIL is another member of TNF family and it induces significantly human MSC migration and TNF‐α may modulate this course [Corallini et al, 2010]. However, the question whether or not other members of TNF family, such as LIGHT, activate MSCs remains unclear currently.…”

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confidence: 99%

LIGHT regulates the adipogenic differentiation of mesenchymal stem cells

Liu

Ding

Zhu

et al. 2012

J of Cellular Biochemistry

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LIGHT is a cytokine belonging to the TNF family. This cytokine has been extensively defined in its role on T-cell regulation and dendritic cell maturation. It also exhibits the role in liver regeneration. We recently identified its role in regulation of hematopoietic stem cell differentiation. However, the question whether this cytokine regulates mesenchymal stem cells (MSCs) proliferation and/or differentiation remains unknown. In this study, we observed that MSCs express LT-βR but not HVEM. PCR analysis show LIGHT mRNA is undectable in MSCs. LIGHT did promote neither MSCs proliferation nor migration. However, LIGHT promoted MSCs differentiation into adipocyte which was confirmed by Oil Red O Staining Assay. Since either MSCs or adipocytes are the major cell population in bone marrow niche, we then suggest that LIGHT regulate bone marrow niche, such as MSCs differentiation.

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TNF-α modulates the migratory response of mesenchymal stem cells to TRAIL

Cited by 20 publications

References 44 publications

Cell-Based Therapies for Diabetic Complications

Cell-Based Therapies for Diabetic Complications

Characteristics of stem cells derived from rat fascia: In vitro proliferative and multilineage potential assessment

LIGHT regulates the adipogenic differentiation of mesenchymal stem cells

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