To evaluate safety and efficacy of tedizolid phosphate in the management of several skin infections

Abstract

Tedizolid Phosphate is an oxazolidinone-class antibiotic and is used for the treatment of acute bacterial skin and skin structure infections. it is a prodrug activated by plasma or intestinal phosphatases to tedizolid following administration of the drug either orally or intravenously. Once activated, tedizolid exerts its bacteriostatic microbial activity through inhibition of protein synthesis by binding to the 50S ribosomal subunit of the bacteria. The purpose of the study was to evaluate safety and efficacy of Tedizolid phosphate and compare it with that of Lenizolid Phosphate another oxazolidinone class of drugs. The study was conducted at OMNI hospital located at dilsukhnagar, Hyderabad. 126 subjects with skin infections, who satisfied the eligibility criteria, were accrued during the study period. These patients were randomized into 2 groups, and were then evaluated according to the treatment protocol. Investigational product was then administered to evaluate safety and efficacy parameters. Subjects received treatment according to the study arm/group. Subjects were asked to take drug for 7 days daily once orally till the clinical symptoms disappear/ as per PIs discretion. Samples for microbiological evaluation were done at screening, end of the therapy. Among both the formulations the group the received Tedizolid phosphate was considered safer and more efficacious as Clinical success rate was 89.9% and the group that received Lenizolid phosphate had the clinical success rate of 81%. It can be concluded that Tedizolid phosphate could be promising drug in the treatment of various skin infections.

APTC-C-SA01: A Novel Bacteriophage Cocktail Targeting Staphylococcus aureus and MRSA Biofilms

“…This list included Staphylococcus aureus , a commensal that colonizes more than 30% of American adults’ nasal cavities but can also cause infections in a range of severity and localizations [ 10 ]. These infections include local skin infections such as folliculitis, boils, and pustules, as well as abscesses, and can spread to bone tissue (osteomyelitis), lungs (Staphylococcal pneumonia), blood (bacteremia or sepsis), heart (infective endocarditis), and other organs [ 11 , 12 , 13 , 14 ]. Compared with MSSA, infections with MRSA have a higher morbidity and mortality rate [ 15 ] and are associated with higher treatment costs and longer hospital stays.…”

Local Drug Delivery Strategies towards Wound Healing

“…Effective antiseptics for local wounds include polyhexanide and octenidine dihydrochloride. Nitrofuran and natrium fusidate are other antibacterial substances ( Table 1 ) [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ].…”

“…Infection is always a possibility. Since they only have fibroblasts and keratinocytes, they are unable to develop differentiated structures including sweat and sebum glands, hair follicles that cycle, pigmentation, sensory innervation, and motor innervation, as well as the epidermal barrier and dermal–epidermal junction [ 39 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 ,…”