To Feed or Not to Feed – Nutritional Risk Assessment and Support in Elective Colorectal Surgery. A Prospective Study on the Effect of Screening

Kollár, Dániel; Benedek-Tóth, Zoltán; Drozgyik, András; Molnár, Tamás; Oláh, Attila

doi:10.1080/01635581.2022.2077384

Cited by 1 publication

(1 citation statement)

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“…Colorectal cancer (CRC) ranks third among malignancies in terms of global incidence and is most commonly observed between 40 and 50 years of age. 1 Colorectal cancer accounts for almost 50% of all incident cases in men and is the second primary cause of mortality for cancer in the United States. 2 In China, estimates from 2022 showed that there were approximately 592 232 new CRC cases and 309 114 deaths attributed to the disease.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Prognostic Biomarkers for Colorectal Cancer by Bioinformatics Analysis

Niu,

Li,

Lei Luo

et al. 2024

Turkish Journal of Gastroenterology

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Background/Aims: Colorectal cancer (CRC) ranks third among malignancies in terms of global incidence and has a poor prognosis. The identification of effective diagnostic and prognostic biomarkers is critical for CRC treatment. This study intends to explore novel genes associated with CRC progression via bioinformatics analysis. Materials and Methods: Dataset GSE184093 was selected from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) between CRC and noncancerous specimens. Functional enrichment analyses were implemented for probing the biological functions of DEGs. Gene Expression Profiling Interactive Analysis and Kaplan–Meier plotter databases were employed for gene expression detection and survival analysis, respectively. Western blotting and real-time quantitative polymerase chain reaction were employed for detecting molecular protein and messenger RNA levels, respectively. Flow cytometry, Transwell, and CCK-8 assays were utilized for examining the effects of GBA2 and ST3GAL5 on CRC cell behaviors. Results: There were 6464 DEGs identified, comprising 3005 downregulated DEGs (dDEGs) and 3459 upregulated DEGs (uDEGs). Six dDEGs were significantly associated with the prognoses of CRC patients, including PLCE1 , PTGS1 , AMT , ST8SIA1 , ST3GAL5, and GBA2 . Upregulating ST3GAL5 or GBA2 repressed the malignant behaviors of CRC cells. Conclusion: We identified 6 genes related to CRC progression, which could improve the disease prognosis and treatment.

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Section: Introductionmentioning

confidence: 99%