The current study aimed to determine the predictive relationship of family communication, prosocial behavior, and emotional/behavioral problems in adolescents. A sample of 273 adolescents (girls = 148; boys = 125), aged 11–18 years ( M = 14.41, SD = 1.53) were recruited through multistage sampling strategy. Family Communication Scale, Prosocial Scale, and Youth version of Child Behavior Checklist were used to measure family communication, prosocial behavior, and emotional/behavioral problems, respectively. Results indicated a significant positive association of family communication and prosocial behavior ( p < .001), and a significant negative association of family communication ( p < .001) and prosocial behavior ( p < .001) with emotional/behavioral problems. Moreover, mediation analysis revealed that prosocial behavior partially mediated the relationship between family communication and emotional/behavioral problems ( p < .002). Results are discussed in terms of the manifestation of adolescents' problems in traditional and collectivistic cultures.