To Report a Case of Tamoxifen-induced Retinopathy Diagnosed Using Spectral Domain Optical Coherence Tomography

Kwon, Jin Young; Kim, Do-Gyun

doi:10.3341/jkos.2016.57.10.1656

Cited by 1 publication

(1 citation statement)

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“…Following recent marked developments in high-resolution optical coherence tomography scans, this maculopathy induced by low-dose tamoxifen could be visualized. 28 29 30 The dysfunction of Müller cells, which are glial cells that extend vertically throughout the retina, is believed to play a significant role in structural disruption of the retina. 28 …”

Section: Discussionmentioning

confidence: 99%

Uveoretinal Adverse Effects Presented during Systemic Anticancer Chemotherapy: a 10-Year Single Center Experience

Cho¹,

Yoon

Kim

et al. 2018

J Korean Med Sci

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BackgroundThe present study describes our 10-year experience with uveoretinal adverse events that manifest because of chemotherapy.MethodsA retrospective chart review was performed for all patients who presented to the ophthalmologic department while undergoing systemic chemotherapy between July 2005 and June 2015.ResultsA total of 55 patients (mean age, 51.2 years, 38 women [69.1%]) suspected of having uveoretinal disease owing to the use of chemotherapeutic agents alone were enrolled. Breast cancer was the predominant disease (36.4%); noninfectious anterior uveitis (21.8%) was the most common condition. Bilateral involvement was observed in 16 patients (29.1%). Although cisplatin (21.8%) was the most commonly used drug, daunorubicin, cytarabine, tamoxifen, toremifene, and imatinib were also frequently used. The median duration until ophthalmologic diagnosis was 208.5 days (range, 19–5,945 days). The proportion of patients with final visual acuity (VA) < 20/40 Snellen VA (0.5 decimal VA) was 32.7%. However, no relationship was observed between final VA < 20/40 and age, sex, therapeutic agents, and metastasis.ConclusionUveoretinal complications were mostly mild to moderate and exhibited a favorable response to conservative therapy. A considerable number of patients exhibited significant irreversible loss of vision after cessation of the causative chemotherapeutic agent. Ophthalmological monitoring is required during chemotherapy.

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