To Study Brain Stem Auditory  Evoked Potential in Patients with  Type 2 Diabetes Mellitus- A Cross-  Sectional Comparative Study

Sushil, Mishra Indira; Muneshwar, J N; Afroz, Sayeeda

doi:10.7860/jcdr/2016/19336.8791

Cited by 5 publications

(7 citation statements)

References 13 publications

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“…In the present study, BMI and HbA1c values were correlated with the IPL I-III and I-V of both the ears in all subjects; it indicated that, with increase in BMI and HbA1c values the IPL values are increased in diabetic subjects. This finding is in line with the previous research where inter peak latencies were prolonged in uncontrolled T2DM subjects [24]. The inter peak latencies were prolonged in T2DM patients with duration of diabetes more than 7 years [24].…”

Section: Discussionsupporting

confidence: 93%

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Brainstem Auditory Evoked Potentials in Type 2 Diabetes Mellitus

Paluru¹,

Negi²

2021

Hearing Loss - From Multidisciplinary Teamwork to Public Health

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Diabetes mellitus is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action or both. Diabetes affects many systems and produces complications in the human body, in those complications one is diabetic central neuropathy. The pathological mechanisms involved in the central neuropathy include chronic hyperglycaemia, hypoglycaemic episodes, angiopathy and blood–brain barrier dysfunction. Diabetic central neuropathy is detected by using of brainstem auditory evoked response (BAER), Visual evoked potential (VEP), somatosensory evoked potential (SEP). These abnormalities are present at different levels and may appear before appearance of overt complications. The central nervous system abnormalities are more frequent in patients with peripheral neuropathy but evoked potentials can be abnormal even in patients without neuropathy. The BAER is a physiological recording technique to study the auditory pathway and does not require subject’s attention and generates waves during the first 10 ms after the sound stimulus. Each BAER wave is generated by the activation of a sub-cortical component of the auditory pathway with 90% sensitivity and 70–90% of specificity.

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Section: Discussionsupporting

confidence: 93%

“…This finding is in line with the previous research where inter peak latencies were prolonged in uncontrolled T2DM subjects [24]. The inter peak latencies were prolonged in T2DM patients with duration of diabetes more than 7 years [24].…”

Section: Discussionsupporting

confidence: 93%

Brainstem Auditory Evoked Potentials in Type 2 Diabetes Mellitus

Paluru¹,

Negi²

2021

Hearing Loss - From Multidisciplinary Teamwork to Public Health

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“…Body height (Ht) in centimeters was measured without shoes by asking the subjects to stand with their heels, head and buttocks against a stadiometer.Body weight was measured in kilograms (kg) without shoes and minimal clothing. BMI (Kg/m 2 ) [18] was calculated by dividing body weight in kilogram by height in meters square.…”

Section: Methodsmentioning

confidence: 99%

A Comparison of Spirometric Parameters and Serum Malondialdehyde Level in Actively Smoking Chronic Obstructive Pulmonary Disease Patients and Non- Smoking Apparently Normals- A Crosssectional Comparative Study

Ranjana

Sushil

Prasad

2021

JAMMR

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Introduction: The antioxidants requirement depend on one’s exposure to endogenous and exogenous reactive oxygen species.Cigarette smoking leads to increased exposure to reactive oxygen species,hence they require more antioxidant nutrients In this study, we aimed to study the serum levels of malondialdehyde (MDA) as a marker of oxidative stress and pulmonary function tests (PFT) and to study if there is any correlation between PFTand MDA levels in, smokers,chronic obstructive pulmonary disease (COPD) patients. Aim: To compare the pulmonary function tests (PFT) and serum malondialdehyde (MDA) level in smokers, chronic obstructive pulmonary disease (COPD) patients with non-smoker controls. Methods and Materials: N=30, 35-50 years age group smokers, COPD patients were enrolled as cases.N=30 age and sex matched were enrolled as control group. Serum MDA and PFT parameters like forced vital capacity (FVC), forced expiratory volume in first second (FEV1), FEV1/FVC ratio, Peak expiratory flow rate (PEFR) were measured. Result: PFT parameters like forced vital capacity (FVC), forced expiratory volume in first second (FEV1), FEV1/FVC ratio, peak expiratory flow rate(PEFR) were decreased and found statistically significant in smokers, COPD group.MDA level were increase and found statistically highly significant in smokers, COPD group. Conclusion: MDA is negatively correlated with FEV1% predicted, FEV1/FVC % predicted ratio and FVC in smokers, COPD patients

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“…4,5 Pemeriksaan BERA adalah tes dengan menggunakan alat elektrofisiologis non-invasif untuk mendeteksi adanya lesi retrokoklear, oleh sebab itu pemeriksaan ini dapat sangat membantu dalam memandu klinisi dalam deteksi gangguan awal dari saraf auditoris dan fungsi batang otak. Beberapa perubahan yang dapat ditemukan pada pasien DM dengan gangguan pendengaran sensorineural dapat dideteksi dengan mengevaluasi latensi absolut gelombang I, III, V, serta masa laten antar-puncak (interpeak latencies [IPL]) I-III, III-V, dan I-V. 5 Pemeriksaan transient evoked otoacoustic emission (TEOAE) dilakukan untuk menentukan status mikro-mekanik koklear, khususnya fungsi dari sel-sel rambut luar (outer hair cells (OHC)). Pemeriksaan TEOAE dilakukan menggunakan alat neuroaudio dengan stimulus klik 'non-linier' dengan durasi 80µs, tingkat pengulangan 50Hz dan intensitas ~80dB.…”

Section: Pendahuluanunclassified

“…Pada beberapa penelitian menyebutkan mikroangiopati bertanggung jawab akan neuropati diabetik, dimana hal tersebut menjelaskan insidens yang lebih tinggi dari evoked response batang otak pada pasien dengan lama menderita penyakit lebih dari 6-7 tahun. 5 Pada penelitian kami kadar HbA1c rata-rata 8,20±1,13%, menunjukkan bahwa kontrol glikemik yang buruk masih lebih dominan sebagai penyebab menurunnya respon TEOAE.…”

Section: Diskusiunclassified

Hasil BERA & TEOAE dengan kadar HbA1c pada pasien Diabetes Melitus tipe-2

Primadewi

Sudrajad

Prasetya

2019

Oto Rhino Laryn Indones

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Latar belakang: Neuropati adalah salah satu komplikasi yang paling sering dari Diabetes Melitus(DM) tipe 2. Disamping neuropati perifer dan otonom, pasien dengan DM tipe 2 juga dapat menderitagangguan pendengaran tipe sensorineural hearing loss (SNHL) pada frekuensi tinggi. Pada studi inihubungan HbA1c dengan hasil pemeriksaan brainstem evoked response audiometry (BERA) dan transient evoked otoacoustic emissions (TEOAE) digunakan untuk mendeteksi neuropati akustik dan sentral pada pasien DM tipe 2. Tujuan: Untuk mengetahui hubungan kadar HbA1c pada DM tipe 2 dengan masa laten gelombang BERA dan respon TEOAE. Metode: Desain penelitian cross sectional study, dilakukan dari Maret 2018 hingga jumlah sample terpenuhi. Penelitian dimulai dengan mengidentifikasi pasien DM tipe 2 dengan profil kadar HbA1c, kemudian dilanjutkan dengan pemeriksaan TEOAE dan BERA. Hasil: Dari hasil pemeriksaan BERA terdapat hubungan signifikan antara HbA1c dengan masa laten gelombang BERA di intensitas 70 dB dan 80 dB kecuali latensi antar-puncak I-V, tetapi tidak berhubungan signifikan pada intensitas 90 dB. Didapatkan pada pemeriksaan TEOAE di telinga kanan kadar HbA1c berhubungan dengan hasil pemeriksaan TEOAE kategori refer rata-rata 8,67+1,14%, sedangkan pasien dengan hasil pemeriksaan TEOAE kategori pass rata-rata 7,73+0,95%. Hasil uji t test didapatkan nilai p=0,021 (p<0,05). TEOAE di telinga kiri kategori refer rata-rata 8,82+1,09%, sedangkan pasien dengan hasil pemeriksaan TEOAE kategori pass rata-rata 7,66+0,88%. Hasil uji t test didapatkan nilai p=0,003 (p<0,05). Kesimpulan: Terdapat hubungan yang signifikan secara statistik antara kadar HbA1c dengan hasil pemeriksaan gelombang BERA dan TEOAE. Background: Neuropathy is complication of type 2 diabetes mellitus (DM). Besides peripheraland autonomic neuropathy, patients with type 2 DM may also have sensorineural hearing loss at highfrequency. In this study the association of HbA1c level with the results of BERA and TEOAE tests was used to detect acoustic and central neuropathy in type 2 DM patients. Objective: To find out the relationship of HbA1c level in type 2 DM with BERA and TEOAE. Method: Research design cross sectional study, conducted from March 2018 until the number of samples fulfilled. The study began by identifying patients with type 2 DM with the HbA1c profile, followed by TEOAE and BERA examinations. Result: There was a significant relationship between HbA1c and the latent period of waves at the intensity of 70 dB and 80 dB except on the interpeak I-V latency, but not significantly related to the 90 dB intensity. Results of TEOAE test in the right ear: the average levels of HbA1c with refer category results on TEOAE test was 8.67+1.14 %, whereas patients with pass category results on TEOAE was 7.73+0.95 %. The result of t test value was p=0.021 (p<0.05). TEOAE on the left ear: average refer category 8.82+1.09%, whereas patients with TEOAE examination results in the mean pass category 7.66+0.88%. The result of t test value was p=0.003 (p<0.05). Conclusion: There was a statistical significant relationship between HbA1clevel and BERA and TEOAE.

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To Study Brain Stem Auditory Evoked Potential in Patients with Type 2 Diabetes Mellitus- A Cross- Sectional Comparative Study

Cited by 5 publications

References 13 publications

Brainstem Auditory Evoked Potentials in Type 2 Diabetes Mellitus

Brainstem Auditory Evoked Potentials in Type 2 Diabetes Mellitus

A Comparison of Spirometric Parameters and Serum Malondialdehyde Level in Actively Smoking Chronic Obstructive Pulmonary Disease Patients and Non- Smoking Apparently Normals- A Crosssectional Comparative Study

Hasil BERA & TEOAE dengan kadar HbA1c pada pasien Diabetes Melitus tipe-2

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