To Study the Levels of C - Reactive Protein and Total Leucocyte Count in Patients Operated of Open and Laparoscopic Cholecystectomy

Kohli, R. N.; Bansal, Ekta; Gupta, Ashwani K; Matreja, Prithpal S; Kaur, Kulwinder

doi:10.7860/jcdr/2014/7094.4487

Cited by 7 publications

(6 citation statements)

References 7 publications

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“…On the other hand, measurement of insulin resistance using homeostatic model assessment-insulin resistance (HOMA-IR) has the same diagnostic value, and it is much simpler and cheaper. Positive correlation between HOMA-IR and CRP concentration and the severity of inflammatory response was reported in several studies (3, 4, 5, 6, 7). It was also demonstrated that postoperative insulin resistance is a temporary phenomenon for at least five days after uncomplicated cholecystectomy, particularly after an open approach (8).…”

Section: Introductionmentioning

confidence: 53%

“…Different results concerning postoperative levels of CRP were reported, favoring the laparoscopic approach over open surgery (30). CRP was superior to white cell count in predicting acute cholecystitis except in the case of pericholecystitis abscesses and biliary peritonitis due to gallbladder perforations when CRP and WBC performed equally well (14).…”

Section: Discussionmentioning

confidence: 99%

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Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

Telo

Kuluöztürk

Deveci

et al. 2018

Journal of Medical Biochemistry

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SummaryBackground: The aim of this study was to determine the level of serum cystatin C (CysC) in patients with Chronic Obstructive Pulmonary Disease (COPD) during exacerbation and stable periods and to investigate its potential diagnostic value and the relationship between CysC levels and the pulmonary function test (PFT). Methods: One hundred twenty-six patients with COPD (68 in stable periods, 58 during exacerbation periods) and 50 healthy subjects were included in the study. PFT, body mass index (BMI), white blood cell counts, C-reactive protein (CRP), serum urea and creatinine levels were evaluated in both groups of patients. CysC levels were measured in all participants. Results: Serum CysC levels were statistically higher in both COPD groups than the control group (p<0.001 for both) although there was no statistically significant difference between COPD groups (p>0.05). CysC levels showed negative correlation with forced expiratory volume in 1 second (FEV 1 ) and a positive correlation with C-reactive protein (CRP) levels in patients with stable COPD. There was a positive correlation between serum CysC levels and serum urea, creatinine, CRP levels in patients with COPD exacerbation (r=0.333, p=0.011; r=0.260, p=0.049; r=0.414, p<0.01 respectively). When stable COPD and control groups were evaluated, serum CysC had an area under the curve (AUC) in the receiver operating characteristic (ROC) curve of 0.951 (0.909-0.994 95% CI: p<0.001).

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Section: Introductionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

Telo

Kuluöztürk

Deveci

et al. 2018

Journal of Medical Biochemistry

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“…However, it has also been observed for cholecystectomies specifically that cytokine markers of inflammation and immunosuppression were significantly higher in LC over OC, although other studies have shown the opposite; that OC is associated with higher strain on the immune system. [16,17,23,24] Along with this, it has also been shown that the rate of surgical site infection in LC and OC is not significantly different, despite the increased incisional area in OC. [22] There are also still clear indications for OC to be performed, such as when the patient is unlikely to tolerate LC .…”

Section: Discussionmentioning

confidence: 71%

Laparoscopic Cholecystectomy Has Better Safety in Comparison to Open Surgery for Occurrence of Death and Myocardial Infarction

Keele¹,

Hashemzadeh²,

Movahed³

2023

Preprint

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Background: Laparoscopic cholecystectomy has gained popularity. The goal of this study was to evaluate outcome differences between open vs laparoscopic cholecystectomy. Method: Using a large NIS database and ICD-9 coding for open vs laparoscopic cholecystectomy, we compared inpatient outcomes for these two procedures regarding the occurrence of myocardial infarctions and mortality using uni- and multivariate analysis by studying 5 years of data from 2010 to 2015. Results: Open cholecystectomy was inferior to laparoscopic procedure with a higher occurrence of non-ST-elevation myocardial infarction (Non-STEMI), ST-elevation myocardial infarction (STEMI), and mortality in comparison to laparoscopic cholecystectomy. For example, using 2010 database, the occurrence of STEMI was 0.2 vs 0% (OR 3.1, CI 1.7-5.5, p<0.001), for Non-STEMI 1 vs 0.4% (OR 2.5 CI 2.0-3.0, p<0001) and for mortality 0.4 vs 0.4% (OR 9.2, CI 7.9-10.6, p<0001). After adjustment for age, obesity, diabetes, and hypertension, the occurrence of STEMI, Non-STEMI, and mortality remained higher in the open cholecystectomy cohort (mortality multivariate OR 6.4, CI 5.5-7.4, p<0001). Conclusion: Open cholecystectomy is associated with a higher rate of STEMI, Non-STEMI, and a markedly higher rate of mortality in comparison to the laparoscopic approach. Our study suggests that laparoscopic cholecystectomy should remain the first choice for patients needing gallbladder surgery.

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“…C-reactive protein (CRP) is an acute reactive protein (APRP) synthesized by the liver that can react with the C-polysaccharide in the Streptococcus pneumoniae capsule. 6 It is part of the non-specific immune mechanism, and its main biological function is to activate the classical pathway of complement by binding to ligands (phosphocholine of apoptotic and necrotic cells, or invading bacteria, fungi, parasites, etc. ), enhance leukocytophagocytosis, and stimulate the activation of lymphocytes or monocytes/macrophages as opsonins.…”

Section: Introductionmentioning

confidence: 99%

A One Step Strategy Based on Hollow Gold Nanoparticles to Detect C-Reactive Protein with High Sensitivity (Hs-CRP) in Serum for Monitoring Cardiovascular Disease

Luo,

Zhang,

Liu

et al. 2024

IJN

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Purpose Rapid detection and diagnosis of diseases facilitate timely and effective treatment of cardiovascular diseases (CVD). The establishment of a one-step rapid detection method provides a new method for the initial screening and disease risk assessment of patients with cardiovascular diseases in primary medical units. Methods Hollow gold nanoparticles (HGNPs) were synthesized using a cobalt template method followed by use as signal amplification probes for ultra-sensitive quantitative detection of serum C-reactive protein (CRP). To induce the localized surface plasmon resonance (LSPR) and improve protein labeling efficiency, we developed a sensitive detection mode by coating polyvinylpyrrolidone (PVP-K30) on the HGNPs, resulting in a significant improvement in detection performance. Results Compared to traditional colloidal GNP-based LFTA, PVP-coated HGNPs exhibit a lower visual detection limit of 1 ng/mL, which a 25-fold decrement compare to using GNPs as the antibody-labeled probe, and the detection limit could be reduced to 0.14 ng/mL under the quantitative instrument. Conclusion The one-step method based on HGNP immunochromatographic strips modified with PVP established in this study can be used for the detection of CRP and hs-CRP in biological samples. The performance of the immunochromatographic technique designed in this study was evaluated from the perspective of synthetic markers, and the application conditions of this strip were screened, verifying its high specificity, indicating that it has high sensitivity and strong detection limit compared to colloidal gold. The sensitivity of the hollow gold immunochromatographic test strip in this article has been increased by about 25 times, providing a new method for rapid detection of CVD in clinical diagnosis.

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To Study the Levels of C - Reactive Protein and Total Leucocyte Count in Patients Operated of Open and Laparoscopic Cholecystectomy

Cited by 7 publications

References 7 publications

Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

Laparoscopic Cholecystectomy Has Better Safety in Comparison to Open Surgery for Occurrence of Death and Myocardial Infarction

A One Step Strategy Based on Hollow Gold Nanoparticles to Detect C-Reactive Protein with High Sensitivity (Hs-CRP) in Serum for Monitoring Cardiovascular Disease

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