To Study The Prevalence of Ocular Manifestations in Rheumatoid Arthritis And their Correlation with Anti Cyclic Citrullinated Peptide Antibodies And Rheumatoid Factor .

Kaur, Prempal; Bal, Bhavkaran Singh; Singh, Baljinderpal; Duggal, Ashok; Kaur, Inderjit

doi:10.9790/0853-1509105863

Cited by 4 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were no instances of scleritis during the study. Fadhil and Al-Dabbagh observed the same conclusion 2017; however, scleritis was identified in 2% of patients in earlier research (23,24,30) .…”

Section: Discussionmentioning

confidence: 59%

“…They were grouped by age intervals, as illustrated in Table 2; just over half (52.1%) were between 41 and 50, and a third (33.9%) fell within the 51-60 age range. Only three (2.5 %) were in their twenties (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). There were 14 cases between the ages of 31 and 40, representing 11.6% of the total.…”

Section: Resultsmentioning

confidence: 99%

“…Kaur et al, 2016 conducted a study on 139 RA patients; 38% had signs of RA-related eye disease, and 31 %complained of dry eye (24) . Additionally, A crosssectional study by Pegu et al,2018 on 114 RA patients revealed that 42.1% exhibited ocular involvement, with dry eyes accounting for 31.5%.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Prevalence of Eye Involvements in Rheumatoid Arthritis and Their Correlation With Anti-Cyclic Citrullinated Peptide Antibody in Sulaimani Governorate/Iraq

Mustafa,

Mirza,

Rasool

2023

JSMC

View full text Add to dashboard Cite

BackgroundRheumatoid arthritis is a common autoinflammatory disease that affects the joints and causes several extra-articular problems, including ocular involvement, which typically manifests in the anterior ocular region. The anti-CCP has a sensitivity comparable to the rheumatoid factor and higher specificity for identifying the disease. ObjectivesTo estimate the prevalence of eye involvements in Rheumatoid arthritis and their correlation to the anti-cyclic citrullinated peptide antibody. Patients and MethodsA cross-sectional study of 121 patients who satisfied the 2010 ACR/EULAR RA Classification Criteria (6/10 or more points) were between 18 and 60. After establishing a patient’s medical history and physical examination, blood samples were collected to test for anti-CCP antibodies, and an eye exam was conducted. ResultsThere were significantly more females than males;104 (86%) were female, and 17 (14%) were males. The median age was 47(42−53.5) years. The median disease duration was 4(2−10) years. The mean disease activity was 3.86 ±1, and the median anti-cyclic citrullinated antibody titers were 29.18(16.75−133.35) U/ml. The overall eye complications typical of Rheumatoid arthritis were observed in 37 (30.6%) and 84 (69.4%) without eye involvement. Dry eyes were the most frequent eye complaint (29.8%). One instance with episcleritis (0.8%). One with filamentary keratitis (0.8%). Anterior uveitis was detected in two cases (1.7%). Eye involvement correlated with anti-cyclic citrullinated peptide antibody (P- value 0.004). ConclusionEye manifestations of rheumatoid arthritis were a prominent part of extra-articular manifestation. The dry eye was the most apparent manifestation, and they correlated to the anti-CCP antibody.

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Prevalence of Eye Involvements in Rheumatoid Arthritis and Their Correlation With Anti-Cyclic Citrullinated Peptide Antibody in Sulaimani Governorate/Iraq

Mustafa,

Mirza,

Rasool

2023

JSMC

View full text Add to dashboard Cite

show abstract

“…However, contrary to our results, there was a difference between the first and third groups. In other studies, the diabetic group with HbA1c levels greater than 7% had a thicker cornea than those with HbA1c levels less than 7% [49][50] . Based on our results, anterior, central, posterior, and total corneal densitometric values had a weak negative correlation with FBS levels.…”

Section: Resultsmentioning

confidence: 71%

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Narooie-Noori¹,

Mirzajani²,

Jafarzadehpur³

et al. 2023

Int J Ophthalmol

View full text Add to dashboard Cite

AIM: To compare anterior segment parameters between two groups of type 2 diabetic with and without diabetic retinopathy (DR) and non-diabetic elderly subjects based on hemoglobin A1c (HbA1c) levels and status of DR. METHODS: This study was conducted on 997 residents aged 60y or over in Tehran, Iran. Diabetic group had HbA1c level ≥6.4% with no other systemic problems. The non-diabetic participants had normal eye findings and no systemic diseases. K1, K2, mean K, Q-value, anterior, central, posterior, and total corneal densitometric findings, anterior chamber volume (ACV), anterior chamber depth (ACD), corneal volume (CV), and pachymetry were measured by Pentacam AXL. RESULTS: A total of 678 non-diabetic (39% male) and 319 diabetic (35% male) subjects with mean age of 66.31±5.23 and 67.22±4.96y were examined, respectively. No statistically significant difference was found in anterior segment parameters between non-diabetic and diabetic groups (all P>0.05). However, middle, posterior, and total corneal densitometric values were statistically different between two groups after controlling the effects of confounders (P=0.014, 0.007, and 0.042, respectively). Corneal densitometric values in all layers, ACD, and ACV were different between diabetic subjects with and without DR (all P<0.05). In the diabetic group, only corneal densitometric values had a negative relationship with fasting blood sugar (P<0.001). ACD and ACV had a negative correlation with HbA1c levels (all P<0.05, r=-0.129 and -0.146, respectively). However, the relationships were not observed after controlling the confounders (P=0.938, 0.466, respectively). CONCLUSION: Considering the higher densitometric values of the cornea and lower ACD and ACV in diabetic subjects with DR, it is suggested that the examiners should perform comprehensive retinal examinations when faced with such conditions.

show abstract

“…Premkal et al, (2016) tried to find a relation between anti CCP, Rheumatoid Factor and ocular manifestations [20]. Out of 139 patients, 53(38%) patients had ocular manifestations.…”

Section: Salient Findings Include: -mentioning

confidence: 99%

Observational Study of Magnitude of Ocular Manifestations of Rheumatoid Arthritis in A Tertiary Care Hospital in East India

Dutta¹,

Dutta²

2019

IJOES

View full text Add to dashboard Cite

Background:Objectives: 1. To evaluate the magnitude of ocular manifestations in patients suffering from rheumatoid arthritis 2. To establish a statistical significance of age of patients to duration of disease 3. To establish a statistical significance of duration of disease to frequency of ocular manifestations Method: Study Design: Cross sectional observational study. Sample Size: 144 Duration of Study: 18 months Case control was not required in this study. Investigations:Slit lamp biomicroscopy with 90 D Volk lens was done for anterior and posterior segment examination. Gonioscopy, Applanation Tonometry, Automated Perimetry and Indirect Ophthalmoscopy were done. Dry eye evaluation was done. Statistical Analysis: SPSS version 20 was used with a p value of less than 0.05 taken as significant. Result: Out of 144 patients, females (118) dominated. Ocular manifestations were seen in 53(36.8%) patients, bilateral in 35 (66%) patients and multiple in 32 (60.4%) patients. Dry eye was the most common ocular manifestation (30.5%). The duration of disease was statistically significant (p=0.001) with respect to ocular manifestations and also age groups (p=0.000). Conclusion:Dry eye was the most common ocular manifestation. The duration of disease was statistically significant with respect to ocular manifestations. The duration of disease was statistically significant when co related with age groups. Ocular manifestations are common in Rheumatoid Arthritis and should be evaluated urgently. Earlier diagnosis of Rheumatoid Arthritis helps in reducing ocular morbidity and ophthalmologists should be trained to look for ocular as well as other extra articular manifestations in Rheumatoid Arthritis.

show abstract

To Study The Prevalence of Ocular Manifestations in Rheumatoid Arthritis And their Correlation with Anti Cyclic Citrullinated Peptide Antibodies And Rheumatoid Factor .

Cited by 4 publications

References 12 publications

The Prevalence of Eye Involvements in Rheumatoid Arthritis and Their Correlation With Anti-Cyclic Citrullinated Peptide Antibody in Sulaimani Governorate/Iraq

The Prevalence of Eye Involvements in Rheumatoid Arthritis and Their Correlation With Anti-Cyclic Citrullinated Peptide Antibody in Sulaimani Governorate/Iraq

Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

Observational Study of Magnitude of Ocular Manifestations of Rheumatoid Arthritis in A Tertiary Care Hospital in East India

Contact Info

Product

Resources

About