Tobacco and fertility: our responsibilities

Dorfman, Sally Faith

doi:10.1016/j.fertnstert.2008.01.011

Cited by 26 publications

(17 citation statements)

References 8 publications

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“…Because much of the reduced fecundity associated with smoking could be reversed within a year of cessation (Dorfman, 2008), the clinical significance of the present finding should be to develop effective interventions aimed at helping patients stop smoking for the benefits to general health and for their fertility.…”

Section: Discussionmentioning

confidence: 94%

“…In particular, we did not find a relation between smoking and sperm motility, and this could be partly due to the small size of our sample group and to the severe criteria used to select the population of men with idiopathic infertility used in this study. We also cannot exclude that our patients, particularly nonsmoker patients, might have been exposed to secondhand smoke, which can cause immediate harm (Dorfman, 2008) and, in particular, to prenatal exposure to tobacco smoke, which has been demonstrated to have an adverse effect on semen quality (Ramlau-Hansen et al, 2007b).…”

Section: Discussionmentioning

confidence: 99%

“…A causal relationship between cigarette smoking and impaired reproductive function is highly suspected in the literature (Dorfman, 2008). Many studies have examined the effects of cigarette smoking on male fertility, and the results have suggested a substantial negative effect on sperm production, motility, and morphology (Weber et al, 2002;Kunzle et al, 2003;Ramlau-Hansen, 2007a).…”

Section: Discussionmentioning

confidence: 99%

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Semen Quality of Male Idiopathic Infertile Smokers and Nonsmokers: An Ultrastructural Study

Collodel

Capitani

Pammolli

et al. 2010

Journal of Andrology

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This retrospective study was aimed at evaluating the effects of cigarette consumption on semen parameters in a group of men with idiopathic infertility. The semen quality of 2 groups of men with idiopathic infertility, smokers (n 5 118) and nonsmokers (n 5 153), were compared. Conventional semen analysis was performed and sperm morphology was assessed by transmission electron microscopy (TEM). TEM data were elaborated by means of a mathematical formula based on a Bayesian technique able to furnish a fertility index (FI), and the percentages of sperm apoptosis, necrosis, and immaturity. Values of normality recommended by World Health Organization guidelines were used as a control for conventional semen analysis, and values from sperm of 25 men of proven fertility were used for TEM indices. Infertile smoker and nonsmoker patients showed similar sperm parameters, although sperm motility and TEM analysis values in both groups were significantly impaired compared with controls. Smoker patients were then classified as mild ($1 and #10 cigarettes/d), moderate (.10 and ,20 cigarettes/day), or heavy smokers ($20 cigarettes/d). Sperm concentration and FI were significantly (P , .05) different among the 3 considered smoker classes. Comparing the pairs of smoker classes, sperm concentration and FI in heavy smokers were significantly lower (P , .05) than that observed in mild smoker and nonsmoker groups. Although semen quality in males with idiopathic infertility seems not to be dramatically affected by cigarette consumption, heavy smokers show significantly lower sperm concentration and FI: another strong reason to stop smoking.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Semen Quality of Male Idiopathic Infertile Smokers and Nonsmokers: An Ultrastructural Study

Collodel

Capitani

Pammolli

et al. 2010

Journal of Andrology

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“…Many studies have examined the effects of cigarette smoking on male fertility and the results Different studies have assessed the relationship between smoking and semen quality ushave suggested a substantial negative impact on sperm production, motility and morphology (23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

“…However, Collodel et al, (26) reported that although the semen quality of males with idiopathic infertility seems to not be dramatically affected by cigarette consumption, heavy smokers show signifi cantly lower sperm concentration. They attributed this discrepancy to the small size of sample group, or to the possibility that non-smoker patients may have been exposed to second hand smoke, which can cause immediate harm (23) and in particular, to prenatal exposure to tobacco smoke which has been demonstrated to have an adverse effect on semen quality (34). The mechanism behind the harmful effect of smoking on semen quality is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Apoptotic markers in semen of infertile men: association with cigarette smoking

El-Melegy

Ali

2011

Int. braz j urol.

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Objectives: (i) To examine the role of apoptosis in the pathogenesis of DNA damage in semen from infertile men. (ii) To assess the effects of smoking on apoptotic markers and seminal parameters among infertile men. (iii) To assess the correlation of apoptosis with conventional semen parameters. Materials and Methods:The study was carried out on 70 men with idiopathic infertility, divided into two groups: thirty infertile non smokers and forty infertile smokers. In addition to 60 fertile men (30 non smokers and 30 smokers) as control group. Each subject provided semen for analysis of parameters, determination of % of DNA fragmentation, s-Fas, caspase-3 activity levels and cotinine levels. Results:The results revealed that infertile men, particularly smokers have significantly lower semen variables and significantly higher levels of apoptotic variables (% of DNA fragmentation, s-Fas and caspase-3 activity) in addition to cotinine. Conclusions:The present findings provide additional evidence supporting the importance of the evaluation of apoptotic markers to test male infertility particularly among smokers.

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