Tobacco Industry Wastewater–Induced Genotoxicity in Mice Using the Bone Marrow Micronucleus and Sperm Morphology Assays

Alabi, Okunola A.; Osifo-Whiskey, Evi; Yadi, Precious; Lawal, Moruf; Bakare, Adekunle A.

doi:10.1508/cytologia.79.215

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…Current techniques of manufacturing tobacco products are quite different from ancient methods as it includes many additive chemicals to provide better taste (Gönen, 2005). However, large quantities of wastewater are generated in tobacco industries during processing and cigarette-making which may be toxic to the environment and public health (Alabi et al, 2014). Tobacco manufacturing is two-step process where first step is the production of tobacco that does not contribute to contaminate the water.…”

Section: Introductionmentioning

confidence: 99%

Germination and Seedling Leaf Chlorophyll Content of Wheat (Triticum aestivum L.) Grown under Industrial Wastewater Condition

Pramanik

Sikder

2020

Agriculturists

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The tobacco industry is one of the biggest industries in the world generates and disposes large quantities of wastewater in the environment which may be toxic to the plant, animal, public health as well as environment. Therefore, an experiment was conducted during November, 2019 at Crop Physiology and Ecology Laboratory, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh to observe the effects of tobacco industry wastewater on germination, early seedling growth and seedling leaf chlorophyll content of wheat (TriticumaestivumL.). Three wheat genotypes (BARI Gom 28, BARI Gom 29 and BAW 1177) and two growing conditions (normal tap water and tobacco industry wastewater) were assigned in a completely randomized design with three replications in germination test. Results showed that germination characteristics, seedling growth and chlorophyll content in leaf of seedling significantly influenced by wheat genotype, growing condition and their interaction. Irrigation with tobacco industry wastewater lowered the germination percentage, rate of germination, co-efficient of germination and vigor index. However, seedlings irrigated with tobacco industry wastewater produced longer shoot and root as compared to seedlings irrigated with tap water. Similarly, tobacco industry wastewater increased the shoot and root dry weight but reduced the chlorophyll content in leaf of seedling. Among the three wheat genotypes, BAW 1177 performed better under both tap water and wastewater conditions regarding germination, early growth and chlorophyll content in leaf of seedling. The Agriculturists 2020; 18(1) 10-17

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Section: Introductionmentioning

confidence: 99%

Germination and Seedling Leaf Chlorophyll Content of Wheat (Triticum aestivum L.) Grown under Industrial Wastewater Condition

Pramanik

Sikder

2020

Agriculturists

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“…A decrease in the number of viable sperm cells in an organism may be an additional factor in male infertility. 42 …”

Section: Discussionmentioning

confidence: 99%

“…The result was pooled for all the mice/group and then reported as mean sperm count/mL of suspension. 42 …”

Section: Methodsmentioning

confidence: 99%

Bisphenol A-induced Alterations in Different Stages of Spermatogenesis and Systemic Toxicity in Albino Mice ( Mus musculus )

Alabi

Ologbonjaye

Sorungbe

et al. 2021

Journal of Health and Pollution

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Background. Bisphenol A (BPA) is known to alter sperm morphology, but information is limited on the most susceptible stage(s) of spermatogenesis, especially in mice. Objectives. This study investigated the reproductive, biochemical, and hematological changes caused by exposure to BPA in male albino mice. The genotoxicity of BPA to the six stages of spermatogenesis in mice was determined. Methods. Mice were exposed orally to BPA at 0.5, 1.0, 2.0, and 5.0 mg/kg bw doses for 5 days and assessed for sperm morphology after 35 days. Based on the result, the second group of mice was exposed to BPA at 1.0 mg/kg bw dose for 5 days, their spermatozoa were assessed for sperm morphology based on BPA exposure at the 6 maturation stages of spermatogenesis: spermatozoa, elongating spermatids, round spermatids, secondary spermatocytes, primary spermatocytes, and spermatogonia. Biochemical and hematological analyses of the blood of exposed mice were also carried out. Results. The results showed that BPA induced concentration-dependent, significantly (p<0.05) increased sperm cell abnormalities at three of the four concentrations tested, with the exception of 0.5 mg/kg bw, in comparison with the negative control. The highest frequency of sperm aberrations was induced in spermatozoa exposed to BPA while at the primary spermatocytes. The order of induced sperm abnormality at the different stages of exposure was: primary spermatocytes > elongating spermatids > spermatozoa > spermatogonia > round spermatids > secondary spermatocytes. The results of the biochemical analysis showed significantly (p<0.05) increased serum urea, creatinine, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities with a concomitant decrease in total protein content at the various stages of spermatogenesis. In addition, the results for hematological parameters showed several significant (p<0.05) modulations in mice exposed to BPA. Conclusions. These data showed that BPA is most toxic to primary spermatocytes and alterations of biochemical and hematological parameters might be the mechanisms of induced toxicity. Ethics Approval. The Research Ethics Committee, Federal University of Technology, Akure approved the study protocols. Competing Interests. The authors declare no competing financial interests

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“…Interestingly, many of these industrial effluents are discharged untreated into water bodies, partly because of weak regulations, thereby contaminating the receiving surface and ground waters. Reports have shown that effluents from pharmaceutical industry (Bakare et al, 2009;, hospitals (Iyekhoetin et al, 2011), universities (Alabi et al, 2012), tobacco industry (Alabi et al, 2014), automobile workshops (Alabi et al, 2016) and cocoa industry (Alabi et al, 2017) contained heavy metals and other chemical constituents in high concentrations capable of contaminating drinking water sources and lead to public health detrimental effects.…”

Section: Industrial Effluentsmentioning

confidence: 99%

Review of Drinking Water Quality in Nigeria: Towards Attaining the Sustainable Development Goal Six

Nwinyi

Uyi

Awosanya

et al. 2020

Annals of Science and Technology

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Access to potable water is a major problem confronting most developing nations particularly with the overwhelming health burden posed by polluted water and its sources. In this review, studies on the level of contamination of drinking water sources in different geopolitical zones in Nigeria were assessed. The anthropogenic activities eliciting the pollutions were extensively discussed. Overall, the level of Nigeria preparedness in meeting the sustainable development goal number 6 (SDG no 6: to ensure availability and sustainable management of water and sanitation for all) was evaluated. Cogent methods that could enhance the achievement of SDG no. 6 were suggested. From our analysis of published literature, pre- and post- SDG implementation in Nigeria, it is clear that no significant progress has been made in providing potable water for all in Nigeria. All implementing partners must therefore rejig the process to ensure the availability of potable water, in order to achieve the sustainable development goal six.

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Tobacco Industry Wastewater–Induced Genotoxicity in Mice Using the Bone Marrow Micronucleus and Sperm Morphology Assays

Cited by 7 publications

References 24 publications

Germination and Seedling Leaf Chlorophyll Content of Wheat (Triticum aestivum L.) Grown under Industrial Wastewater Condition

Germination and Seedling Leaf Chlorophyll Content of Wheat (Triticum aestivum L.) Grown under Industrial Wastewater Condition

Bisphenol A-induced Alterations in Different Stages of Spermatogenesis and Systemic Toxicity in Albino Mice ( Mus musculus )

Review of Drinking Water Quality in Nigeria: Towards Attaining the Sustainable Development Goal Six

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