Tocilizumab treatment for refractory uveitis-related cystoid macular edema

Abstract

These data suggest that TCZ is effective for treating CME in otherwise treatment-refractory cases of uveitis.

The Promise and Limitations of TNF-α Inhibition for Uveitis

“…Others have described similarly beneficial responses to tocilizumab in selected patients with refractory uveitis. [18][19][20][21][22][23] Taken together, these findings support the notion that the use or addition of an anti-TNF-a agent can help achieve control of uveitis in a high proportion of patient with uveitis, particularly those with Behçet's disease and JIA, two conditions for which TNF-a inhibitors are now strongly recommended as standard of care in the step-wise management of ocular inflammation. 24 The studies cited above also highlight, however, some of the limitations of TNF-a inhibitors, including the unpredictably varied response of each TNF-a inhibitor in an individual patient, both initially and over time, and the disappointingly low rate of successful discontinuation.…”

Uveitis in Juvenile Idiopathic Arthritis: Recent Therapeutic Advances

“…A handful of cases of recalcitrant JIA-associated uveitis treated with tocilizumab have been described as part of two small case series collected at the University of Barcelona [16,17] , which included patients with other uveitis subtypes. Thus, while it is too early to speculate about the usefulness of the drug for this disease in particular, tocilizumab certainly is a potential addition to the biological armamentarium that is used to treat JIA-associated uveitis.…”

Non-anti-TNF biologic modifier drugs in non-infectious refractory chronic uveitis: The current evidence from a systematic review

“…Full text of the remaining 84 studies and 5 additional articles obtained by screening of their references was scrutinized. From the selection process, a total of 11 relevant articles were deemed eligible: 3 on rituximab [9][10][11], 3 on abatacept [12][13][14], 3 on tocilizumab [15][16][17], 1 on alemtuzumab [18], and 1 on anakinra [19]. Of the 11 articles, 6 reported data exclusively on adults [15][16][17][18], 3 included both children and adults [11,13,14], and the remaining 2 reported exclusively on children [12,19].…”