Tocotrienol Nanoemulsion Platform of Curcumin Elicit Elevated Apoptosis and Augmentation of Anticancer Efficacy against Breast and Ovarian Carcinomas

Steuber, Nelson; Vo, Kathy T.; Wadhwa, Ritambhara; Birch, J.; Iacoban, Paulina; Chavez, Pedro I.; Elbayoumi, Tamer

doi:10.3390/ijms17111792

Cited by 25 publications

(17 citation statements)

References 32 publications

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“…The tocotrienol nanoemulsion platform of curcumin can be used to treat breast and ovarian carcinoma. 7 Fatty acid/poly(lactic-co-glycolic acid) NPs used as a drug delivery system enhance the in vitro cytotoxicity and in vivo targeting potential of paclitaxel against ovarian cancer stem cells. 8 addition to others.…”

Section: Routes Of Np Entry Into the Reproductive System Direct Path mentioning

confidence: 99%

Potential adverse effects of nanoparticles on the reproductive system

Wang¹,

Song²,

Wu³

et al. 2018

IJN

171

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With the vigorous development of nanometer-sized materials, nanoproducts are becoming widely used in all aspects of life. In medicine, nanoparticles (NPs) can be used as nanoscopic drug carriers and for nanoimaging technologies. Thus, substantial attention has been paid to the potential risks of NPs. Previous studies have shown that numerous types of NPs are able to pass certain biological barriers and exert toxic effects on crucial organs, such as the brain, liver, and kidney. Only recently, attention has been directed toward the reproductive toxicity of nanomaterials. NPs can pass through the blood–testis barrier, placental barrier, and epithelial barrier, which protect reproductive tissues, and then accumulate in reproductive organs. NP accumulation damages organs (testis, epididymis, ovary, and uterus) by destroying Sertoli cells, Leydig cells, and germ cells, causing reproductive organ dysfunction that adversely affects sperm quality, quantity, morphology, and motility or reduces the number of mature oocytes and disrupts primary and secondary follicular development. In addition, NPs can disrupt the levels of secreted hormones, causing changes in sexual behavior. However, the current review primarily examines toxicological phenomena. The molecular mechanisms involved in NP toxicity to the reproductive system are not fully understood, but possible mechanisms include oxidative stress, apoptosis, inflammation, and genotoxicity. Previous studies have shown that NPs can increase inflammation, oxidative stress, and apoptosis and induce ROS, causing damage at the molecular and genetic levels which results in cytotoxicity. This review provides an understanding of the applications and toxicological effects of NPs on the reproductive system.

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Section: Routes Of Np Entry Into the Reproductive System Direct Path mentioning

confidence: 99%

Potential adverse effects of nanoparticles on the reproductive system

Wang¹,

Song²,

Wu³

et al. 2018

IJN

171

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“…. Wide range of formulations such as polymeric micelles, nanoemulsions and liposomes have been reported to enhance the performance of curcumin both in-vitro and in-vivo, yet the exact mechanism of drug delivery by most of the curcumin-loaded NPs is not fully clear (Steuber et al, 2016;Lin et al, 2012;Pengying et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Critical parameters dictating efficiency of membrane-mediated drug transfer using nanoparticles

Abbasi

Kajimoto

Harashima

2018

International Journal of Pharmaceutics

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Curcumin, a low molecular weight, hydrophobic compound, exhibits strong anti-cancer effects and has a high margin of safety. However, its poor water solubility, rapid metabolism and degradation make it relatively ineffective, but intracellular delivery using nanoparticles (NPs) would solve these problems. In this study, we formulated curcumin in two-structurally distinct NPs: a nanoemulsion (Cur-NE) and a Niosome (Cur-NIO), evaluated their in-vitro cytotoxic effects and examined their mechanisms of drug delivery. The use of Cur-NIO resulted in an unexpected increase in the intracellular accumulation of curcumin and induced a potent cytotoxic effect compared to Cur-NE. To our surprise, however, the effects of the endocytosis of NIO as well as that for NE on the cellular delivery of curcumin were negligible. Consequently, we concluded that Cur-NIO delivers curcumin directly to the cytosol via transfer from the NIO to the cell membrane. The results of Förster resonance energy transfer (FRET) and phase-transfer studies indicate that Cur-NIO exhibits efficient transfer into model membranes or organic interfaces. Moreover, we found that Cur-NE shows a poor transfer efficiency. This could be due to the presence of a hydrophobic oil core that reduces the probability of curcumin to transfer upon contact with the membrane. To the best of our knowledge, this is the first study of the effect of NP structure on the membrane-mediated transfer efficiency of low molecular weight, hydrophobic compounds.

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“…Moreover, it was found that gemcitabine-γ-tocotrienol conjugates were least affected by deamination deactivation reaction in vitro when compared with the free and conjugated gemcitabine in solution (Abu-Fayyad and Nazzal 2017). CUR/δ-T3 tocotrienol NEs with average particle size of 261 nm, PDI 0.27 and zeta potential of 35 mV significantly suppressed constitutive NF-κ B activation, and significantly induced apoptosis in breast and ovarian cancer cells, MCF-7 and OVCAR-8 (Steuber et al 2016). Hyaluronic acid-complexed PTX NEs containing DL-α-tocopheryl acetate and soybean oil with a diameter of 85.2±7.55 nm and a zeta potential of -35.7±0.25 mV administered at a dose of 25 mg/kg to nude mice transplanted with CD44-overexpressing non-small cell lung carcinoma cells xenografts suppressed cancer cell growth more than the Taxol and strongly inhibited tumor growth, which could be connected with the specific tumor-targeting affinity of HA for CD44-overexpressed cancer cells (Kim and Park 2017a).…”

Section: Nanoemulsions For Cancer Therapymentioning

confidence: 97%

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Jampílek

Kráľová

Campos

et al. 2019

Nanotechnology in the Life Sciences

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Nanotechnology providing "a new dimension" accompanied with new properties conferred to many current materials is widely used for production of a new generation of agrochemicals, in medicine it enables improved drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and specific targeting to certain target cells, while in food industry it has great importance in food protection and biofortification of food with valuable ingredients. In biobased nanoemulsions belonging to lipid nanocarriers plant oils used for oil phase, emulsifiers, biosurfactants, cosurfactants, targeting ligands on the surface of nanoemulsion (e.g., folate) or encapsulated active ingredients are of natural origin. The biocomponents of such nanoemulsions show low toxicity to living organisms, could protect encapsulated compounds for degradation, ensure their sustainable release and reduce the amount of active ingredient necessary for required effect. This chapter presents a comprehensive current overview of recent findings in the field of nanoemulsions and their utilization in agriculture and food industry, with the main emphasis on formulations encapsulating essential oils or plant extracts suitable as effective pesticide preparations as well as medicinal applications of bio-based nanoemulsions, where attention is paid to transdermal nanoemulsion formulations, the use of nanoemulsions in cancer therapy and for pulmonary and ocular drug delivery. Nanoemulsions formulated with natural emulsifiers, biosurfactants and biopolymers are presented and bio-based nanoemulsions of essential oils and their constituents as well as nanoemulsions with encapsulated vitamins, fatty acids and some bioactive compounds are discussed. Applications of nanoemulsions in edible coatings are outlined as well.

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Tocotrienol Nanoemulsion Platform of Curcumin Elicit Elevated Apoptosis and Augmentation of Anticancer Efficacy against Breast and Ovarian Carcinomas

Cited by 25 publications

References 32 publications

Potential adverse effects of nanoparticles on the reproductive system

Potential adverse effects of nanoparticles on the reproductive system

Critical parameters dictating efficiency of membrane-mediated drug transfer using nanoparticles

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

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