Toe out angle: a functional index for the evaluation of sciatic nerve recovery in the rat model

Varejão, Artur S.P.; Cabrita, António; Geuna, Stefano; Melo‐Pinto, Pedro; Filipe, Vítor; Gramsbergen, Albert; Meek, Marcel F.

doi:10.1016/s0014-4886(03)00208-5

Cited by 76 publications

(63 citation statements)

References 31 publications

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“…The use of biomechanical techniques and rat's gait kinematic evaluation was a progress in documenting functional recovery, largely published by our research group [3,9,17,31,33,35] . Indeed, the use of biomechanical parameters allows an accurate analysis of the sciatic denervation/reinnervation process, permitting to understand the integration of the neural control acting on the ankle and foot muscles, and thus allowing to evaluate the nerve and muscle regeneration after neurogenic muscle atrophy associated to neurotmesis injuries [60,61] . At the end of the 20-wk healing period, it was performed kinematic gait analysis of rats from the groups where it was applied the biomaterial alone or associated to MSCsbased therapies (PVA, PVA-CNTs, PVA-PPy, and PVACNTs-MSCs groups) and measures of ankle joint angle at the four selected instants of the stance phase (IC, OT, HR and TO) were obtained (Table 3 and Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

Ribeiro¹,

Pereira²,

Caseiro³

et al. 2015

WJSC

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Section: Discussionmentioning

confidence: 99%

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

Ribeiro¹,

Pereira²,

Caseiro³

et al. 2015

WJSC

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“…A camera (Nikon-Japan) was positioned underneath the transparent base plate in order to photograph the plantar surface of the animals ' paws. Angles were measured and recorded (Varej ã o et al, 2003).…”

Section: Toe Out Anglementioning

confidence: 99%

Behavioral evaluation of regenerated rat sciatic nerve by a nanofibrous PHBV conduit filled with Schwann cells as artificial nerve graft

Biazar

Keshel

Pouya

2013

Cell Communication & Adhesion

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The aim of this study is to develop a nanofi brous polymeric nerve conduit with Schwann cells (SCs) and to evaluate its effi ciency on the promotion of functional and locomotive activities in rats. The conduits were implanted into a 30-mm gap in the sciatic nerves of the rats. Four months after surgery, the rats were monitored and evaluated by behavioral analyses such as toe out angle, toe spreading analysis, walking track analysis, extensor postural thrust, open-fi eld analysis, swimming test and nociceptive function, four months post surgery. Four months post-operatively, the results from behavioral analyses demonstrated that in the grafted groups especially in the grafted group with SCs, the rat sciatic nerve trunk had been reconstructed with functional recovery such as walking, swimming and recovery of nociceptive function. This study proves the feasibility of artifi cial conduit with SCs for nerve regeneration by bridging a longer defect in the rat model.

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“…The SFI derived from walking track analysis in rats provides a reliable and easily quantifiable method for the assessing of motor function after sciatic nerve injury (Varejão et al, 2003). This gait analysis is based on the fact that rats normally walk on their digits and metatarsal footpads.…”

Section: Discussionmentioning

confidence: 99%

Effects of Herbal Bath "HAC" on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Sciatic Crushed Nerve Injury in Rats

Ryu¹,

Lim²,

Song³

et al. 2009

Exp Neurobiol

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Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits. c-Fos expression is sometimes used as a marker of increased neuronal activity. We have developed herbal bath "HAC" for pain control using the following herbs: Harpagophytum procumbens, Atractylodes japonica, and Corydalis tuber. In the present study, we investigated the effects of herbal bath "HAC" on the recovery rate of the locomotor function and the expression of c-Fos in the ventrolateral periaqueductal gray (vlPAG) region of brain following sciatic crushed nerve injury in rats. Walking track analysis for the evaluation of functional recovery and immunohistochemistry for the c-Fos expression were used for this study. In the present results, characteristic gait change with dropping of the sciatic function index (SFI) was observed and c-Fos expression in the vlPAG was suppressed following sciatic crushed nerve injury in rats. Immersion into herbal bath "HAC" enhanced SFI value and restored c-Fos expression in the vlPAG to the control value. These results suggest that herbal bath "HAC" might activate neurons in the vlPAG, and it facilitates functional recovery from peripheral nerve injury. Here we showed that herbal bath "HAC" could be used as a new therapeutic intervention for pain control and functional recovery from peripheral nerve injury.

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Toe out angle: a functional index for the evaluation of sciatic nerve recovery in the rat model

Cited by 76 publications

References 31 publications

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

Behavioral evaluation of regenerated rat sciatic nerve by a nanofibrous PHBV conduit filled with Schwann cells as artificial nerve graft

Effects of Herbal Bath "HAC" on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Sciatic Crushed Nerve Injury in Rats

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