This paper investigates the convergence of risk, sustainability, and supply chain in space missions, including a review of fundamental concepts, the introduction of a multi-objective conceptual optimization model, and the presentation of a practical approach. Risks associated with space missions include technical, human, launch, space environment, mission design, budgetary, and political risks. Sustainability considerations must be incorporated into mission planning and execution to ensure the long-term viability of space exploration. The study emphasizes the importance of considering environmental sustainability, resource use, ethical concerns, long-term planning, international collaboration, and public outreach in space missions. It emphasizes the significance of reducing negative environmental consequences, increasing resource use efficiency, and making responsible and ethical actions. The paper offers a multi-objective optimization conceptual model that may be used to evaluate and choose sustainable space mission tactics. This approach considers a variety of elements, including environmental effects, resource utilization, mission cost, and advantages for society. It provides a systematic decision-making approach that examines trade-offs between different criteria and identifies optimal conceptual model solutions that balance risk, sustainability, and supply chain objectives. A practical approach is also offered to demonstrate the use of the multi-criteria optimization conceptual model in a space mission scenario. The practical approach demonstrates how the model can aid in the development of mission strategies that minimize risks, maximize resource consumption, and fit with sustainability goals. Overall, this paper delivers a multi-criteria optimization conceptual model and provides a space mission planning practical approach, as well as an overview of the interaction between risk, sustainability, and supply chain in space mission organization, planning, and execution.