Tolerability and safety of olive oil–based lipid emulsion in critically ill neonates: A blinded randomized trial

Webb, Annette; Hardy, Pollyanna; Peterkin, Megan; Lee, Olive; Shalley, Helen; Croft, Kevin D.; Mori, Trevor A.; Heine, Ralf G.; Bines, Julie E

doi:10.1016/j.nut.2008.05.004

Cited by 55 publications

(44 citation statements)

References 39 publications

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“…An RCT in critically ill neonates requiring parenteral nutrition in the first week of life reported similar results in terms of fatty acid levels and oxidative stress (F 2 -isoprostanes) [23]. Roggero et al [24 ] conducted a threearm RCT in preterm neonates (gestation 28-33 weeks) randomized to receive either soybean oil-based lipid emulsion (Intralipid, B. Braun), or olive oil-based lipid emulsion (Clinoleic, Baxter Pharmaceuticals), or soybean oil/MCT-based lipid emulsion (Lipofundin, B. Braun).…”

Section: Oxidative Stress and Fatty Acid Levelsmentioning

confidence: 78%

Lipids for parenteral nutrition in neonates

Deshpande

Simmer

2011

Current Opinion in Clinical Nutrition and Metabolic Care

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Since the first soybean oil-based lipid emulsions were introduced 50 years ago, progress has been made in understanding the composition, dose and clinical effects of parenteral lipids in neonatal patients. However there is a paucity of data in terms of definitive head-to-head trials of different novel lipid emulsions evaluating short-term as well as long-term clinically important outcomes including neurodevelopment. Future research is required to determine long-term benefits of novel lipid emulsions for neurological outcome and effects on the immune system.

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Section: Oxidative Stress and Fatty Acid Levelsmentioning

confidence: 78%

Lipids for parenteral nutrition in neonates

Deshpande

Simmer

2011

Current Opinion in Clinical Nutrition and Metabolic Care

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“…Olive oil based lipid emulsions have been found to be well tolerated by critically ill and preterm neonates. [3,4,5,6]. Several in vitro and animal studies have reported suppression of T-lymphocyte function and impaired bacterial clearance by soybean oil based lipid emulsion compared with minimal effect from olive oil based emulsion.…”

Section: Spn Formulationsmentioning

confidence: 99%

“…In addition there are concerns regarding excess of poly-unsaturated fatty acids (PUFAs) and low vitamin E levels in soybean oil based lipid emulsions [8]. Although, the clinical studies have failed to show any short term benefits of using olive oil based emulsions on fatty acid profile and anti-oxidant properties, the fatty acid profile of preterm neonates in Clinoleic group was similar to breast milk fed preterm neonates [4,5,6]. ClinOleic ® 20% lipid emulsion contains a mixture of 80% olive oil and 20% soybean oil and is given as a 24 h infusion piggy-backed to the rest of the PN solution containing glucose, amino acids, electrolytes and vitamins.…”

Section: Spn Formulationsmentioning

confidence: 99%

Standardised Parenteral Nutrition

2013

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Parenteral nutrition (PN) has become an integral part of clinical management of very low birth weight premature neonates. Traditionally different components of PN are prescribed individually considering requirements of an individual neonate (IPN). More recently, standardised PN formulations (SPN) for preterm neonates have been assessed and may have advantages including better provision of nutrients, less prescription and administration errors, decreased risk of infection, and cost savings. The recent introduction of triple-chamber bag that provides total nutrient admixture for neonates may have additional advantage of decreased risk of contamination and ease of administration.

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“…In one small randomized clinical trial comparing soybean oil-and olive oil-based emulsions, olive oil emulsions were found to be well-tolerated in ELBW infants, resulting in comparable measures of peroxidation to those seen with soybean oil-based lipid emulsions [18]. Similar results were observed in a randomized, double-blind comparison of olive oil emulsion with soybean oil emulsion in critically ill neonates [19]. Gobel et al [20] compared their standard soybean lipid emulsion to one in which olive oil and soybean oil were combined (4 : 1) and in which additional ␣tocopherol was provided.…”

Section: Recent Developments In Tpn For Lbw Neonatesmentioning

confidence: 65%

Current trends and future challenges in neonatal parenteral nutrition

Adamkin

Radmacher

2014

Journal of Neonatal-Perinatal Medicine

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A number of adaptations in total parenteral nutrition (TPN) protocols and practices for preterm neonates have been realized in the past several years, resulting in better survival and developmental outcomes. The early provision of appropriate concentrations of amino acids and energy are now recommended in evidence-based guidelines. Standardized TPN formulations are now available for many patients and may be associated with cost savings and improved adherence to guidelines. Several advantages of these preparations, including promotion of safer administration, consistent adherence to guidelines, and overall best practices, have been well documented. However, careful monitoring is still required to optimize nutrition for individual patients and to support overall safety as TPN practices continue to change. Additional research is needed to develop new lipid formulations that are tailored for safe use by very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. This review presents recent research and improvements to guidelines, as well as future product needs for VLBW and ELBW neonates.

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Tolerability and safety of olive oil–based lipid emulsion in critically ill neonates: A blinded randomized trial

Cited by 55 publications

References 39 publications

Lipids for parenteral nutrition in neonates

Lipids for parenteral nutrition in neonates

Standardised Parenteral Nutrition

Current trends and future challenges in neonatal parenteral nutrition

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