Tolerability of different oral iron supplements: a systematic review

Cancelo-Hidalgo, M.J.; Castelo-Branco, Camil; Palacios, Santiago; Haya-Palazuelos, Javier; Recasens, M. Ciria; Manasanch, José; Pérez-Edo, Lluís

doi:10.1185/03007995.2012.761599

Cited by 250 publications

(205 citation statements)

References 54 publications

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“…However, placebo controlled studies in pregnant women have shown that ferrous iron doses of 105 mg/day has a side effect profile, which is not significantly different from placebo [47,48]. The slow release iron formulas Ferro Duretter, IberetFolic and ferrous sulphate with mucoproteose (Tardyferon) have fewer gastrointestinal side-effects (nausea, epigastric pain, constipation) than fast release formulas [45,49,50]. Actually, Ferro Duretter has a side effect profile being comparable to placebo tablets [49].…”

Section: Iron Formulas: Fast and Slow Release Formulasmentioning

confidence: 99%

Iron Deficiency and Anaemia in Pregnant Women in Malaysia ? Still a Significant and Challenging Health Problem

Milman¹

2015

J Preg Child Health

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Section: Iron Formulas: Fast and Slow Release Formulasmentioning

confidence: 99%

Iron Deficiency and Anaemia in Pregnant Women in Malaysia ? Still a Significant and Challenging Health Problem

Milman¹

2015

J Preg Child Health

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“…These preparations have several negative side effects, including gastrointestinal distress (Peña-Rosas et al, 2012;Cancelo-Hidalgo et al, 2013) and changes in the composition of colonic microflora (Zimmermann et al, 2010;Dostal et al, 2012). These methods also result in defects in body structural elements caused by the formation of reactive oxygen species (Kehrer, 2000).…”

Section: Introductionmentioning

confidence: 99%

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Sizova¹,

Yausheva²,

Kosyan³

et al. 2015

MAS

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We studied the influence of highly dispersed elemental iron preparations on the productivity and metabolism of broiler chicks. Iron nanoparticles were synthesized using high-temperature condensation. No toxicity of the nanoparticles and their agglomerates was observed in an experiment utilizing a genetically engineered luminescent strain of Escherichia coli (K12 TG1). The efficiency of single intramuscular injections in 120 broiler chicks (Smena 7) of preparations containing iron particles with sizes of 80 ± 5 nm (nanoparticles), 923.7 ± 29.6 nm (nanoparticle agglomerates) or 9.8 ± 0.4 nm (microparticles) was compared. The use of these preparations increased the live weight of the chickens. The maximum difference in live weight was observed 4 days after the injection of nanoparticles (9.8%; P ≤ 0.01), 17 days after the injection of agglomerates (4.97%; P ≤ 0.01), and 17 days after the injection of microparticles (8.5%; P ≤ 0.01). Injections with iron preparations were accompanied by increased protein deposition, causing daily weight gain in chickens. This gain was higher by 1.3 -4.3 g when nanoparticles were used, by 0.6 -1.4 g for agglomerates, and by 0.1 -1.4 g for microparticles. The iron preparations promoted an increase in the arginine content of the chicken liver compared with that of control animals. After the use of nanoparticles, the arginine content increase was 2.25% (P ≤ 0.05) within 1 day and 3.78% (P ≤ 0.05) 7 days after injection. The arginine content increased by 2.08% (P ≤ 0.05) 7 days after the use of agglomerates and by 3.86% (P ≤ 0.05) 21 days after the use of microparticles. Thus, similar biological effects were shown for different sizes of elemental iron particles. These effects were enhanced as the particle size decreased, although further investigation is required before the joint use of metal nanoparticles and arginine.

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“…They are likely due to direct toxicity of unabsorbed iron on the intestinal mucosa. Two recent meta-analyses including several thousands of patients receiving ferrous iron salts have reported gastrointestinal AEs in proportion variables from 30 to 70% of cases [56,57]. The ensuing reduction of adherence, in combination with the need of prolonged treatment (see above), results in undertreatment of a significant proportion of IDA patients in daily clinical practice.…”

Section: A Far From Ideal Treatmentmentioning

confidence: 99%

Modern iron replacement therapy: clinical and pathophysiological insights

et al. 2017

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Iron deficiency, with or without anemia, is extremely frequent worldwide, representing a major public health problem. Iron replacement therapy dates back to the seventeenth century, and has progressed relatively slowly until recently. Both oral and intravenous traditional iron formulations are known to be far from ideal, mainly because of tolerability and safety issues, respectively. At the beginning of this century, the discovery of hepcidin/ferroportin axis has represented a turning point in the knowledge of the pathophysiology of iron metabolism disorders, ushering a new era. In the meantime, advances in the pharmaceutical technologies are producing newer iron formulations aimed at minimizing the problems inherent with traditional approaches. The pharmacokinetic of oral and parenteral iron is substantially different, and diversities have become even clearer in light of the hepcidin master role in regulating systemic iron homeostasis. Here we review how iron therapy is changing because of such important advances in both pathophysiology and pharmacology.

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Tolerability of different oral iron supplements: a systematic review

Abstract: Extended-release ferrous sulfate with mucoproteose appears to be the best tolerated of the different oral iron supplements evaluated.

Cited by 250 publications

References 54 publications

Iron Deficiency and Anaemia in Pregnant Women in Malaysia ? Still a Significant and Challenging Health Problem

Iron Deficiency and Anaemia in Pregnant Women in Malaysia ? Still a Significant and Challenging Health Problem

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Modern iron replacement therapy: clinical and pathophysiological insights

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