Tolerance of Oat-Based Topical Products in Cereal-Sensitized Adults with Atopic Dermatitis

Goujon, Catherine; Jean‐Decoster, Catherine; Dahel, Karima; Bottigioli, David; Lahbari, Farida; Nicolas, Jean‐François; Schmitt, Anne-Marie

doi:10.1159/000203649

Cited by 13 publications

(9 citation statements)

References 47 publications

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“…It is a complex multifactorial disease with many possible contributing factors like immunological, genetic, metabolic and neuroendocrine ones, which interact with each other and the environment. Atopic eczema is related to an abnormal barrier function of the skin and early immunoglobulin E production with later allergen/immunoglobulin E reactivity [4,9,10,11,12]. Exposure to allergens, irritants and bacteria [4,9] as well as psychological factors [13] also have an impact on skin conditions.…”

Section: Introductionmentioning

confidence: 99%

Homoeopathic versus Conventional Therapy for Atopic Eczema in Children: Medical and Economic Results

et al. 2009

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Background: One of five children visiting a homoeopathic physician is suffering from atopic eczema. Objective: To examine the effectiveness, safety and costs of homoeopathic versus conventional treatment in usual care. Methods: In a prospective multicentre comparative observational non-randomised study, 135 children (homoeopathy n = 48 vs. conventional n = 87) with mild to moderate atopic eczema were included. The primary outcome was the SCORAD (Scoring Atopic Dermatitis) at 6 months. Further outcomes at 6 and 12 months also included quality of life of parents and children, use of conventional medicine, treatment safety and disease-related costs. Results: The adjusted SCORAD showed no significant differences between the groups at both 6 months (homoeopathy 22.49 ± 3.02 [mean ± SE] vs. conventional 18.20 ± 2.31, p = 0.290) and 12 months (17.41 ± 3.01 vs. 17.29 ± 2.31, p = 0.974). Adjusted costs were higher in the homoeopathic than in the conventional group: for the first 6 months EUR 935.02 vs. EUR 514.44, p = 0.026, and for 12 months EUR 1,524.23 vs. EUR 721.21, p = 0.001. Quality of life was not significantly different between both groups. Conclusion: Taking patient preferences into account, homoeopathic treatment was not superior to conventional treatment for children with mild to moderate atopic eczema.

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Section: Introductionmentioning

confidence: 99%

Homoeopathic versus Conventional Therapy for Atopic Eczema in Children: Medical and Economic Results

et al. 2009

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“…The patch test and a skin prick tests were repeated after the use part of the experiment, and total IgE and A sativa-specific IgE were measured. 102 There were no signs of irritation or sensitization in a HRIPT (n ¼ 104) of a cream containing A sativa (concentration not provided; 50 mL). 58 The test material was administered in a Finn chamber on days 1, 3, 5, 8, 10, 12, 15, 17, and 19, for 48 or 72 hours.…”

Section: Humanmentioning

confidence: 96%

“…In a use study of a cream and soap containing an extract of young A sativa plants, subjects (n ¼ 8 females, 4 males) with a history of cereal-sensitized atopic dermatitis did not develop immediate or delayed-type hypersensitivity in response to the products after using them for 21 days. 102 The cream contained 12% and the soap contained 3% of the extract. Prior to and after the 21-day use study, none of the subjects displayed positive reactions in patch tests and skin prick tests of 5 fractions of the extract used in the products or the study cream.…”

Section: Humanmentioning

confidence: 99%

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Safety Assessment of Avena sativa (Oat)-Derived Ingredients As Used in Cosmetics

Becker¹,

Bergfeld²,

Belsito³

et al. 2019

Int J Toxicol

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This is a safety assessment of Avena sativa (oat)–derived ingredients. The reported functions of these ingredients in cosmetics include abrasives, antioxidant, skin conditioning agents, absorbents, and bulking agents. The Panel reviewed relevant animal and human data related to these ingredients. Because final product formulations may contain multiple botanicals, each containing the same constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may lead to sensitization or other toxic effects. The Panel stated that industry should continue to use good manufacturing practices to limit impurities and concluded that all but one of the Avena sativa (oat)–derived ingredients are safe as cosmetic ingredients in the practices of use and concentration described in this safety assessment when formulated to be nonsensitizing; data are insufficient to come to a conclusion of safety for Avena Sativa (Oat) Meristem Cell Extract.

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“…Contact urticaria occurred to an oat extract emollient cream, and oral allergy syndrome was found to be correlated with eating oatmeal-containing biscuits and bread. 22 Wheat-dependent exercise-induced anaphylaxis is a form of wheat allergy induced by wheat ingestion combined with trigger factors including exercise and/or aspirin intake. The role of hydrolysis on the allergenicity of wheat proteins has been proposed.…”

Section: Sensitization Type I and Type Iv Allergic Contact Reactionsmentioning

confidence: 99%

Oat and Wheat as Contact Allergens in Personal Care Products

Pootongkam

Nedorost

2013

Dermatitis

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Oat and wheat are used as ingredients in various cosmetics and personal care products because of their moisturizing properties. Impaired barrier functions in atopic dermatitis (AD) may increase the risks of sensitization to oat and wheat proteins via skin. Immediate- and delayed-type hypersensitivity reactions to oat and wheat in personal care products have been reported in previous studies, and most of those cases were patients with AD. Patch testing with oat and wheat proteins should be performed more frequently, especially in atopic children. It may help identify contact dermatitis, which may be a cause of flares in patients with AD. Complete avoidance of oat- or wheat-derived products is suggested as we cannot conclude that some oat- or wheat-derived components such as oils are free of protein.

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Tolerance of Oat-Based Topical Products in Cereal-Sensitized Adults with Atopic Dermatitis

Cited by 13 publications

References 47 publications

Homoeopathic versus Conventional Therapy for Atopic Eczema in Children: Medical and Economic Results

Homoeopathic versus Conventional Therapy for Atopic Eczema in Children: Medical and Economic Results

Safety Assessment of Avena sativa (Oat)-Derived Ingredients As Used in Cosmetics

Oat and Wheat as Contact Allergens in Personal Care Products

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