Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection

Abstract

Tolerance to famotidine occurs during continuous administration for 14 days, as previously shown in ranitidine studies.

Does gastroesophageal reflux have an influence on bleeding from esophageal varices?

“…It may be that tolerance developed for the antacid effect of histamine receptor antagonist with long-term administration. 37,38 Therefore, it is considered that proton pump inhibitors are more favorable for the prophylaxis of variceal bleeding than histamine receptor antagonists. Second, the intraesophageal luminal pressure facing the esophageal mucosa was reported to be different at the different mucosal sites.…”

Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H2-receptor knockout

“…The antighrelin antisera do not recognize other enteric peptides. Ghrelin values obtained by N-terminal RIA using the antighrelin [1][2][3][4][5][6][7][8][9][10][11] antiserum specifi cally represent the active, n-octanoylated ghrelin. The values obtained by the C-terminal RIA using the antighrelin [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] antiserum represent the total ghrelin concentration, including the inactive des-acyl ghrelin.…”

“…2 Although this mechanism, in the short term, is recognized as receptor upregulation, 3 its mechanism is still unclear in detail. Other mechanisms not in the histamine pathway may take part in acid secretion after the administration of H 2 RA.…”

Is an intravenous histamine H2 receptor antagonist superior to an intravenous proton pump inhibitor in acid suppression?

“…In particular, when H2RAs are used for more than 2 weeks, they show a prominent tolerance phenomenon and rapidly lose their acid-suppressing effect. 4 PPIs produce potent and longlasting acid suppression and do not show any tolerance phenomenon. Therefore, they achieve a higher endoscopic healing rate and more effective symptomatic relief than H2RAs when used for the longterm treatment of gastroduodenal ulcers and gastroesophageal reflux disease.…”