Tolerogenic microenvironment in neonatal period induced by maternal immunization with ovalbumin

Muniz, Bruno Pacola; Victor, Jefferson Russo; Oliveira, Lucas Ferrari de; Lira, Aline Aparecida de Lima; Perini, Adenir; Olivo, Clarice Rosa; Arantes-Costa, Fernanda Magalhães; Martins, Mílton A.; Duarte, Alberto José da Silva; Sato, Maria Notomi

doi:10.1016/j.imbio.2014.01.002

Cited by 18 publications

(11 citation statements)

References 36 publications

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“…In another approach, it was demonstrated that sensitization of females before mating and then extensive antigen challenges (10 OVA challenges) during lactation resulted in transfer of IgG immune complexes in the milk and induction of regulatory T cells and tolerance in the offspring when offspring were challenged with OVA at 6–8 weeks old; in this model, immune complexes but not TGFβ in the milk was required for tolerance [44]. Similar data were reported for allergic mothers and an offspring 60-day treatment protocol with subcutaneous OVA/alum, intraperitoneal OVA, and then five OVA challenges [45]. In summary, depending on timing, doses, and number of antigen challenges, factors in breast milk can contribute mediators that either increase or decrease offspring responses to allergen.…”

Section: Breast Milk and Offspring Allergymentioning

confidence: 80%

Maternal Influences over Offspring Allergic Responses

Cook‐Mills

2015

Curr Allergy Asthma Rep

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Asthma occurs as a result of complex interactions of environmental and genetic factors. Clinical studies and animal models of asthma indicate offspring of allergic mothers have increased risk of development of allergies. Environmental factors including stress-induced corticosterone and vitamin E isoforms during pregnancy regulate the risk for offspring development of allergy. In this review, we discuss mechanisms for the development of allergic disease early in life, environmental factors that may impact the development of risk for allergic disease early in life, and how the variation in global prevalence of asthma may be explained, at least in part, by some environmental components.

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Section: Breast Milk and Offspring Allergymentioning

confidence: 80%

Maternal Influences over Offspring Allergic Responses

Cook‐Mills

2015

Curr Allergy Asthma Rep

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“…Previous results obtained by our research group in a similar murine model revealed that an offspring derived from a non-immune mother and nursed by an OVA-immunized mother presents an allergen-specific anaphylactic IgE response that is suppressed at a level similar to those observed in offspring that were delivered and nursed by a OVA-immunized mother [6]. In the present work, we found that B10 cell induction can be accessed on 3-day-old offspring from immune mothers, which suggests that the proposed induction of B10 cells is mediated mainly by the transplacental transference of maternal IgG, but we cannot discard the possibility that milk IgG could also participate in the maintenance and/or induction of this mechanism.…”

Section: Discussionmentioning

confidence: 90%

Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

Oliveira

Lira

et al. 2017

Allergy Asthma Clin Immunol

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BackgroundThe mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B10) cell population in offspring in concert with allergy inhibition.MethodsC57BL/6 females were or were not immunized with OVA and were mated with normal WT males. Their offspring were evaluated at 3 days of age or 20 days after neonatal immunization. Human peripheral B cells from atopic and non-atopic individuals were also evaluated.ResultsPreconception OVA immunization induced B10 cells in offspring, and IL-10 production appeared to be critical for FcγRIIB upregulation in offspring B cells. Murine and human IL-10-producing B cells responded in vitro to IgG according to the atopic repertoire of the cells.ConclusionsOur results reveal that maternal immunization induces allergen-specific B10 cells in offspring and a pivotal role for the IgG repertoire in IL-10 production by murine and human B cells.Electronic supplementary materialThe online version of this article (doi:10.1186/s13223-017-0195-8) contains supplementary material, which is available to authorized users.

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“…Our group has been investigating adoptive maternal-foetal immune interactions in the context of allergy regulation. [1][2][3][4][5][6][7][8][9][10] The potential of IgG antibodies as allergy regulators has been discussed for decades. In the early 80s, direct evidence that maternal IgG can suppress IgE production in offspring was obtained in a murine model of ovalbumin (OVA) immunization.…”

Section: Introductionmentioning

confidence: 99%

Low doses of IgG from atopic individuals can modulatein vitroIFN-γ production by human intra-thymic TCD4 and TCD8 cells: An IVIg comparative approach

Sgnotto

Oliveira

Lira

et al. 2017

Human Vaccines & Immunotherapeutics

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The regulatory effect of allergic responses induced by IgG antibodies on human intra-thymic cells has not been reported in the literature. The aim of this study was to evaluate the possible differential effect of purified IgG from atopic and non-atopic individuals on human intra-thymic αβT cell cytokine production. Thymic tissues were obtained from 14 patients who were less than 7 d old. Additionally, blood samples were collected from atopic and non-atopic volunteers. Thymocytes and peripheral blood mononuclear cells were cultured with purified atopic or non-atopic IgG, and intracellular cytokine production was assessed. Purified IgG did not influence the frequency or viability of human intra-thymic αβT cells. Purified non-atopic IgG induced greater IFN-γ production by intra-thymic CD4+CD8+ T cells than did the mock treatment and atopic IgG. A similar effect of purified non-atopic IgG on TCD8 cells was observed compared with the mock treatment. Atopic IgG inhibited IFN-γ and TGF-β production by intra-thymic TCD4 cells. Treatment with intravenous immunoglobulin resulted in intermediate levels of IFN-γ and TGF-β in intra-thymic TCD4 cells compared with treatment with atopic and non-atopic IgG. Peripheral TCD4 cells from non-atopic individuals produced IFN-γ only in response to atopic IgG. This report describes novel evidence revealing that IgG from atopic individuals may influence intracellular IFN-γ production by intra-thymic αβT cells in a manner that may favor allergy development.

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Tolerogenic microenvironment in neonatal period induced by maternal immunization with ovalbumin

Cited by 18 publications

References 36 publications

Maternal Influences over Offspring Allergic Responses

Maternal Influences over Offspring Allergic Responses

Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

Low doses of IgG from atopic individuals can modulatein vitroIFN-γ production by human intra-thymic TCD4 and TCD8 cells: An IVIg comparative approach

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