Toll-like receptor 4 gene polymorphism and early onset of diabetic retinopathy in patients with type 2 diabetes

Buraczyńska, Monika; Baranowicz-Gąszczyk, Iwona; Tarach, Jerzy S.; Książek, Andrzej

doi:10.1016/j.humimm.2008.12.003

Cited by 51 publications

(46 citation statements)

References 33 publications

(28 reference statements)

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“…In the current study, it was confi rmed that T2D participants with a heterozygous genotype of Asp299Gly had a higher prevalence of diabetic retinopathy, despite that the patients' number was low, as has been shown previously (Buraczynska et al 2009). However, the polymorphism was not related to the development of polyneuropathy and did not aff ect the renal function, assessed through eGFR.…”

Section: Discussionsupporting

confidence: 85%

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TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum

Zaharieva

Kamenov

Savov

2017

Endocrine Regulations

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Objectives. Compared to type 1 diabetes, the role of the immune and autoimmune pathogenetic mechanisms is much less studied in the type 2 diabetes. Toll-like receptors 4 (TLR4) have a leading role in infl ammation, insulin resistance, and vascular damage. Th is study aimed to analyze the relationship between the polymorphisms in TLR4 gene and diff erent stages in the glucose continuum from prediabetes to the type 2 diabetes and chronic microvascular complications.Materials and Methods. Th e study included 113 patients with the type 2 diabetes, 29 participants with prediabetes, and 28 controls. Polymerase chain reaction (PCR) was used for genotyping Asp299Gly and Th r399Ile polymorphism, followed by restriction analysis.Results. Th e diff erence in the genotype frequency for both polymorphisms in patients with the type 2 diabetes or prediabetes compared to that in controls was not signifi cant. Patients with heterozygous genotype of Asp299Gly polymorphism had a higher prevalence of diabetic retinopathy (42.9%) than participants with homozygous genotype (9.0%) (OR [95%CI]=7.61 [1.41-41.08]; p=0.018). No association was established for diabetic polyneuropathy and nephropathy. Prevalence of chronic diabetes complications was not related to Th r399Ile polymorphism.Conclusion. Our study demonstrates that Asp299Gly and Th r399Ile polymorphisms seem not to be associated with the type 2 diabetes and prediabetes but Asp299Gly may contribute to diabetic retinopathy predisposition.

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Section: Discussionsupporting

confidence: 85%

“…However, Buraczynska et al (2009) described a predisposing role of the G allele of Asp299Gly to both developments of retinopathy and cardio-vascular disease, but did not confi rm an association with other microvascular complications (Buraczynska et al 2016). …”

Section: Discussionmentioning

confidence: 98%

TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum

Zaharieva

Kamenov

Savov

2017

Endocrine Regulations

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show abstract

“…This +896 A N G TLR-4 polymorphism may be associated with decreased ligand recognition or protein interaction, and altered responsiveness to lipopolysaccharide (LPS). In particular, T2DM patients carrying the AG or the GG genotypes feature an increased risk of developing retinopathy compared with patients carrying the AA genotype [69][70][71].…”

Section: The Tlr-2 and -4 Inflammatory Signaling Pathwaysmentioning

confidence: 99%

Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches

Madonna¹,

Balistreri

Geng

et al. 2017

Vascular Pharmacology

133

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“…Nevertheless, after cautious analysis of the full texts, another 22 papers were excluded owing to missing information, ineligible study designs or because they investigated other TLR4 polymorphisms. Eleven articles fulfilled the eligibility criteria; however, only 7 were included in the meta-analysis: 6 that had been identified through the database searches [5,[17][18][19][20][21], in addition to the case-control study we described above ( Figure S1). The other four studies evaluated the Asp299Gly and Thr399Ile polymorphisms in Asian populations, but they could not be included in the meta-analysis since only the ancestral genotypes were found [39][40][41][42].…”

Section: Meta-analysismentioning

confidence: 99%

Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta- Analysis

Assmann¹,

Lemos²,

Brondani³

et al. 2018

J Diabetes Metab

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Toll-like receptor 4 gene polymorphism and early onset of diabetic retinopathy in patients with type 2 diabetes

Cited by 51 publications

References 33 publications

TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum

TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum

Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches

Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta- Analysis

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