Toll-like receptor 4 rs11536889 is associated with angiographic extent and severity of coronary artery disease in a Chinese population

Abstract

Toll-like receptor 4 (TLR4) is a key modulator in many inflammation-related diseases. Polymorphisms in the TLR4 gene may alter TLR4 expression and affect the extent and severity of coronary artery disease (CAD). We analyzed 3 polymorphisms of TLR4 in 607 Chinese subjects who underwent coronary arteriography. Blood samples were collected to identify the polymorphisms. We evaluated the relationships between the polymorphisms and the number of vessels involved in coronary stenosis, Gensini scores, and Duke prognostic scores. We found that rs11536889 was associated with an increased risk of 3-vessel disease. When subjects with 3-vessel disease were compared to subjects with nonsignificant CAD, rs11536889 variant genotypes were associated with an increased risk of 3-vessel disease (GC/CC vs. GG: OR=2.06, 95%CI=1.21-3.51). When subjects with 3-vessel disease were compared to subjects with 1-vessel disease, rs11536889 variant genotypes were associated with an increased risk of 3-vessel disease (GC vs. GG: OR=2.14, 95%CI=1.20-3.79; GC/CC vs. GG: OR=2.06, 95%CI=1.20-3.54). When subjects with 3-vessel disease were compared to subjects with non-3-vessel disease, rs11536889 variant genotypes were associated with an increased risk of 3-vessel disease (GC vs. GG: OR=1.76, 95%CI=1.12-2.75; GC/CC vs. GG: OR=1.83, 95%CI=1.19-2.82). The TLR4 rs11536889 polymorphism was also related to Gensini score (P=0.02). The Gensini score was higher in subjects with the variant CC and GC/CC genotype than in subjects with the wild GG genotype (61.28 1.84 and 57.6434.82 vs. 51.2734.57). Our results demonstrate that TLR4 rs11536889 polymorphism is a novel genetic factor in the development of CAD, influencing the extent and severity of CAD.

Levels and clinical significance of serum homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), vaspin, and visfatin in elderly patients with different types of coronary heart disease

“…The risk factors may be related to factors such as smoking, obesity, age, and family genetic history. At present, the relationship between new risk factors related to hyperhomocysteinemia, adipokines, and dyslipidemia, and the incidence and progression of CHD in the elderly is gradually receiving more attention (10). The results of this study showed that compared with healthy controls of the same age, elderly patients with CHD had statistically significant differences in BMI, smoking years, CRP, FPG, TC, and FINS.…”

The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk

“…Furthermore, the greatest genetic influence was observed on early‐onset CAD events, 6 which implies a more vital role for genetic factors in determining CAD risk. Genotyping common single nucleotide polymorphisms (SNPs) within a potential CAD–related gene is an essential and efficient method to detect genetic risk markers, and many significant SNPs associated with CAD risk have been reported, such as matrix metalloproteinase‐9 , 7 interleukin‐27 8 and Toll‐like receptor 4 9 …”

TLR4 and MMP2 polymorphisms and their associations with cardiovascular risk factors in susceptibility to aortic aneurysmal diseases

“…Recently, several studies have reported that TLR4rs11536889 and rs1927914 polymorphisms had impacts on human inflammatory and malignant diseases [24–26]. Moreover, Sun et al demonstrated that TLR4 rs11536889 was a novel genetic factor in the development of coronary artery disease, influencing its angiographic extent and severity [27], while Xu et al. found that rs1927914 was correlated with susceptibility to diabetes and diabetic retinopathy in a Chinese Han population [24].…”