Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum Coronarium L.

Tanaka, Sadao; Koizumi, Shin; Masuko, Kazutaka; Makiuchi, Naoko; Aoyagi, Yuka; Quivy, Emi; Mitamura, Rieko; Kano, Tsutomu; Ohkuri, Takayuki; Wakita, Daiko; Chamoto, Kenji; Kitamura, Hiroyuki; Nishimura, Takashi

doi:10.1016/j.intimp.2010.11.026

Cited by 20 publications

(11 citation statements)

References 50 publications

(58 reference statements)

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“…On the other hand, IL-12 added exogenously to the co-culture could significantly promote activation of the NK cells mediated by TLR7 and/ or TLR8. In line with other reports [32,33], the results suggested that type I IFN and IL-12 play important roles in the DC-induced NK cell activation. At the same time, we also detected the up-regulation of IL-15 and IL-18 that has been reported to be required in the activation of NK cells stimulated by DCs in the presence of TLR agonists [34,35].…”

Section: Discussionsupporting

confidence: 92%

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

Zhou

Zhang

et al. 2015

Cancer Letters

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Section: Discussionsupporting

confidence: 92%

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

Zhou

Zhang

et al. 2015

Cancer Letters

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“…There are few reports in the literature regarding the anti-inflammatory properties of the six tested plant extracts on cytokine release; all these studies reported anti-inflammatory responses [8,20,21,[39][40][41][42][43]. Our results were consistent with previous studies demonstrating that all of the six plant extracts tested showed an inhibitory effect on IL-6 production while most of them attenuated the release of IL-10, but relatively with variable responses and in a dosedependent manner.…”

Section: Discussionsupporting

confidence: 91%

Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms

Assaf

Amro

Mashallah

et al. 2016

J Infect Dev Ctries

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Introduction: Methanolic extracts of six plants (Arbutus andrachne, Chrysanthemum coronarium, Inula viscosa, Origanum syriacum, Punica granatum, and Rosmarinus officinalis) used in traditional medicine for the treatment of bacterial and fungal infections were evaluated. The present study was conducted to evaluate the antimicrobial and anti-inflammatory activity of some medicinal plants in lowering the risk of opportunistic infections of the oral cavity caused by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Extracts were evaluated separately and in a mixture. Methodology: The methanolic plant extracts were tested against three opportunistic microorganisms by determining the minimum inhibitory concentration (MIC). They were also evaluated for their ability to suppress the release of the pro-inflammatory cytokine IL-6 while not suppressing the release of the anti-inflammatory cytokine IL-10 from peripheral blood mononuclear cells using ELISA. Results: All extracts showed both antimicrobial and anti-inflammatory activities. However, O. syriacum exhibited the highest antimicrobial activity for the three microorganisms among all of the tested extracts (MIC S. aureus: 1 mg/mL; P. aeruginosa: 2 mg/mL; and C. albicans: 1 mg/mL). The extracts inhibited the expression of the pro-inflammatory cytokine IL-6 with apparent dose-dependent responses while they attenuated the secretion of the anti-inflammatory cytokine IL-10. The mixture of O. syriacum and R. officinalis showed an anti-inflammatory effect, with a synergistic antimicrobial effect. Conclusion: These findings support the idea that a diet rich in plants and herbs may contribute to the reduction of inflammation and microbial growth and may also be preventive against various infections, including those related to the oral cavity.

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“…BM-DCs treated with Amomi Semen extract enhanced the secretion of IL-12 (Fukui et al, 2007). The water extract of Chrysanthemum coronarium L. up-regulated the expression of MHC I, MHC II, CD40, and CD86 as well as IL-12 production of DCs through TLR4-and TLR2-and TLR9-pathways to induce IFN-γ production by mouse spleen cells (Tanaka et al, 2011). The herbal mixture Hochu-ekki-to (BuZhong-Yi-Qi-Tang) increased the number of APCs expressing MHC II and co-stimulatory molecules (CD40, CD80 and/or CD86) as well as IL-12 production in the Peyer's patch of infant mice (Kaneko et al, 2001).…”

Section: Extracts Of Chinese Herb or Herbal Mixturementioning

confidence: 95%

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

Zhang

2015

Journal of Ethnopharmacology

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Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum Coronarium L.

Cited by 20 publications

References 50 publications

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

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